Does Elevated C-Reactive Protein Increase Atrial Fibrillation Risk?

Marott, Sarah; Nordestgaard, Børge G.; Zacho, Jeppe; Friberg, Jens; Jensen, Gorm; Tybjærg‐Hansen, Anne; Benn, Marianne

doi:10.1016/j.jacc.2010.02.066

Cited by 145 publications

(60 citation statements)

References 16 publications

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“…These results are surprising especially when viewed in light of findings from another South African study that showed that Africans have significantly higher levels of CRP when compared to white counterparts [30]. It remains controversial whether CRP is merely a marker [31,32] or indeed causal [33][34][35] in the development of CVD, with strong evidence supporting either statement. Notwithstanding this controversy, CRP remains an important marker to include when investigating CVD development.…”

Section: Discussionmentioning

confidence: 96%

Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function

Rooyen

Schutte

Huisman

et al. 2015

Lung

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Section: Discussionmentioning

confidence: 96%

Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function

Rooyen

Schutte

Huisman

et al. 2015

Lung

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“…C - reactive protein has been associated with chronicity in AF (16). Studies have shown that levels of CRP correlate with inflammation, fibrosis, and remodeling (17).…”

Section: Discussionmentioning

confidence: 99%

A circulating biomarker risk-prediction model correlates with CHADS-2 risk score in chronic atrial fibrillation

Negi

Greener

Anand

et al. 2015

IJC Metabolic & Endocrine

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Background Inflammation and oxidative stress have been linked to the origin and persistence of atrial fibrillation (AF). CHADS-2 scoring system is a risk stratification schema well validated in prognostication of stroke in AF. We evaluated the association of markers of oxidative stress and inflammation with CHADS-2 scores in chronic AF patients. Methods CHADS-2 scores were calculated for 64 subjects with chronic AF. Serum markers of inflammation [C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α)] and of oxidative stress [Derivatives of reactive oxygen metabolites (DROMs) and isoprostanes (IsoPs)] were measured. Results Twenty subjects were categorized as 0 (no risk), 24 as 1 (intermediate risk) and 20 as 2 (severe risk) based on their CHADS-2 scores. High sensitivity-CRP (CHADS-2 0=40.0%, 1=70.0%, 2=90.0%; p=0.003) and DROMs (CHADS-2 0=45%, 1=78%, 2=80%; p=0.04) were positively associated with the CHADS-2 risk score. Subjects with intermediate to severe CHADS-2 risk retained significant associations with abnormal hs-CRP (OR: 5.3, 95%CI: 1.1–25.0) and DROMs (adjusted OR: 6.7, 95%CI: 1.2–38.8) after adjusting for gender and hypertension. In a multiple logistic interaction model, there was no significant interaction between hs-CRP and DROMs in their association with CHADS-2 risk categories (p=0.64). A biomarker risk-model, combining hs-CRP and DROMs, correlated well with the CHADS-2 risk categories (r= 0.49, p<0.001). Conclusions A biomarker risk-model using a combination of hs-CRP and DROMs correlates well with CHADS-2 risk scores in chronic AF. Either or both of these markers may add predictive power to future stroke risk prediction models.

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“…Lastly, elevated C-reactive protein (CRP) is known to be a marker of inflammation and increased CRP levels have been described in people with type 2 diabetes (23). Elevated plasma CRP is robustly associated with increased risk of AF (24). So that increased CRP levels may be responsible for diabetes-AF connection.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical features of atrial fibrillation in diabetic neuropathy: a cross-sectional, observational study

Yağız¹,

Bayata²,

Yeşìl³

et al. 2012

Anadolu Kardiyol Derg

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Does Elevated C-Reactive Protein Increase Atrial Fibrillation Risk?

Abstract: Elevated plasma CRP robustly associated with increased risk of atrial fibrillation; however, genetically elevated CRP levels did not. This suggests that elevated plasma CRP per se does not increase atrial fibrillation risk.

Cited by 145 publications

References 16 publications

Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function

Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function

A circulating biomarker risk-prediction model correlates with CHADS-2 risk score in chronic atrial fibrillation

Prevalence and clinical features of atrial fibrillation in diabetic neuropathy: a cross-sectional, observational study

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