Does allergy explain why some children have severe asthma?

Bonner, Katie; Roberts, Graham

doi:10.1111/cea.13234

Cited by 10 publications

(6 citation statements)

References 141 publications

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“…Several factors and co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients (Figure 2) (32).…”

Section: Allergic Comorbiditiesmentioning

confidence: 99%

Severe Asthma and Allergy: A Pediatric Perspective

et al. 2019

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Severe asthma in children is associated with significant morbidity and lung function decline. It represents a highly heterogeneous disorder with multiple clinical phenotypes. As its management is demanding, the social and economic burden are impressive. Several co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients. Allergen sensitization and/or allergy symptoms may predict asthma onset and severity. A better framing of “allergen sensitization” and understanding of mechanisms underlying progression of atopic march could improve the management and the long-term outcomes of pediatric severe asthma. This review focuses on the current knowledge about interactions between severe asthma and allergies.

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“…Several factors and co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients (Figure 2) (32).…”

Section: Allergic Comorbiditiesmentioning

confidence: 99%

Severe Asthma and Allergy: A Pediatric Perspective

et al. 2019

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“…There is an interrelationship between asthma and food allergy which Bonner et al describe. Many patients have both.…”

Section: Asthma and Rhinitismentioning

confidence: 99%

Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II

Roberts

Almqvist

Boyle

et al. 2019

Clin Experimental Allergy

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“…Asthma is a common chronic respiratory disease with high morbidity and mortality among children worldwide [ 1 ]. It is a complex syndrome characterized by airway hyper-responsiveness (AHR), airway inflammation, and airway remodeling [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Exosomal miR-221-3p Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Asthma Progression by Targeting FGF2 and Inhibiting the ERK1/2 Signaling Pathway

Liu

Lin

Nie

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Exosomes derived from human bone marrow mesenchymal stem cells (BMSCs) play potential protective roles in asthma. However, the underlying mechanisms remain not fully elucidated. Herein, exosomes were isolated from BMSCs, and the morphology, particle size, and exosome marker proteins were identified by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blot, respectively. Then airway smooth muscle cells (ASMCs) were treated with transforming growth factor-β1 (TGF-β1) to construct a proliferation model and then incubated with BMSCs-derived exosomes. We found that exosome incubation increased miR-221-3p expression and inhibited proliferation, migration, and the levels of extracellular matrix (ECM) proteins including fibronectin and collagen III. Moreover, FGF2 was identified as a target gene of miR-221-3p. FGF2 overexpression reversed the inhibitory effects of exosomal miR-221-3p on ASMC progression. Besides, the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) is inhibited by exosomal miR-221-3p, which was reversed by FGF2 overexpression. And ERK1/2 signaling activator reversed the effects of exosomal miR-221-3p on ASMC progression. Additionally, an ovalbumin (OVA)-induced asthmatic mice model was established, and exosome treatment alleviated airway hyper-responsiveness (AHR), histopathological damage, and ECM deposition in asthmatic mice. Taken together, our findings indicated that exosomal miR-221-3p derived from BMSCs inhibited FGF2 expression and the ERK1/2 signaling, thus attenuating proliferation, migration, and ECM deposition in ASMCs and alleviating asthma progression in OVA-induced asthmatic mice. Our findings may provide a novel therapeutic strategy for asthma.

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Does allergy explain why some children have severe asthma?

Cited by 10 publications

References 141 publications

Severe Asthma and Allergy: A Pediatric Perspective

Severe Asthma and Allergy: A Pediatric Perspective

Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II

Exosomal miR-221-3p Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Asthma Progression by Targeting FGF2 and Inhibiting the ERK1/2 Signaling Pathway

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