Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders

Steins‐Loeber, Sabine; Lörsch, Frank; Velde, Caroline van der; Müller, Astrid; Brand, Matthias; Duka, Theodora; Wolf, Oliver T.

doi:10.1007/s00213-020-05534-8

Cited by 12 publications

(12 citation statements)

References 61 publications

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“…Noradrenaline (time: b=-0.06, t(298)=-2. 30 ----Figure 5 ----No significant group or order differences after the Cocaine-Cue-Video were found for AUC G (ps>.058; Tab. 2).…”

Section: Neuroendocrine Responsementioning

confidence: 93%

“…This is in line with Back et al 28 who did not observe enhanced cortisol or subjective stress reactivity to a cue after the TSST in prescription opioid users. Nor did the socially evaluated cold pressor stress test differentially influence the impact of a smoking-related cue on instrumental responding for a smoking-related reward in a Pavlovian-to-instrumental transfer paradigm, thus, was not potentiating drug-seeking behavior 30 .…”

Section: Interaction Between Psychosocial Stress and Cravingmentioning

confidence: 95%

“…To the best of our knowledge, no study has yet tried to disentangle these effects and investigated the influence of a preceding cocaine-cue on subsequent psychosocial stress reactivity. Vice versa, the effect of preceding psychosocial stress on subsequent drug-cue reactivity has been examined in a number of substances [28][29][30][31][32] , but a study in chronic CU is currently lacking. After previous studies investigated stress and craving in CU separately, looking at their combined influence is the next step to increase everyday life validity of results as stress and craving should influence each other on the day-to-day.…”

Section: Introductionmentioning

confidence: 99%

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Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users

Kexel

Kluwe-Schiavon

Baumgartner³

et al. 2022

Preprint

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There is evidence that stress and craving contribute to the development, maintenance, and relapse in cocaine use disorder. Previous research has shown altered physiological responses to psychosocial stress as well as increased vegetative responding to substance-related cues in chronic cocaine users (CU). However, how psychosocial stress and cue-induced craving interact in relation to the physiological response of CU is largely unknown. Therefore, we investigated the interaction between acute psychosocial stress and cocaine-cue-related reactivity in 47 CU and 38 controls. Participants were randomly exposed first to a video-based cocaine-cue paradigm and second to the Trier Social Stress Test (TSST) or vice versa in a crossed and balanced design to investigate possible mutually augmenting effects of both stressors on the physiological stress response. Plasma cortisol, ACTH, and noradrenaline as well as subjective stress and craving were assessed repeatedly over the course of the experimental procedure. Growth models and discontinuous growth models were used to estimate the responses during the cocaine-cue paradigm and TSST. Overall, both groups did not differ in their endocrinological responses to the TSST but CU displayed lower ACTH levels at baseline. The TSST did not elevate craving in CU. However, if the cocaine-cue video was shown first, CU displayed an enhanced cortisol response to the subsequent TSST. Cocaine-cues robustly evoked craving in CU but no stress response, while cue-induced craving was intensified after the TSST. Taken together, CU did not show an altered acute stress response during the TSST but stress and craving together seem to have mutually augmenting effects on their stress response.

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“…Noradrenaline (time: b=-0.06, t(298)=-2. 30 ----Figure 5 ----No significant group or order differences after the Cocaine-Cue-Video were found for AUC G (ps>.058; Tab. 2).…”

Section: Neuroendocrine Responsementioning

confidence: 93%

Section: Interaction Between Psychosocial Stress and Cravingmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users

Kexel

Kluwe-Schiavon

Baumgartner³

et al. 2022

Preprint

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“…At last, while habit was assumed to be the mechanism that the present IC training was directed towards, this assumption was not tested directly, for example by administering a Pavlovian to instrumental Transfer task which aims to assess the effect of conditioned stimuli on instrumental responding (e.g., Steins-Loeber et al, 2020 ).…”

Section: Limitationsmentioning

confidence: 99%

Pilot testing of an adaptive, individualized inhibitory control training for binge drinking: first evidence on feasibility, acceptance, and efficacy

Reichl

Enewoldsen²,

Müller³

et al. 2022

Psychological Research

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Background Deficits in inhibitory control seem to promote habit behavior and therefore play an important role in the development and maintenance of addictive diseases. Although several training approaches have been suggested, there is a considerable lack of knowledge about the best way to improve inhibitory control. Based on a literature review regarding shortcomings of existing trainings, an individualized, adaptive inhibitory control training was developed. We aimed to assess feasibility and acceptance of this training and to provide preliminary results on its efficacy regarding inhibitory control and binge drinking. Methods Sixty-one individuals (30 female) with binge drinking behavior were randomly allocated to either an experimental group receiving three sessions of the inhibitory control training or a waitlist control group receiving no training. Before and after the training, the participants performed a Go/NoGo task to assess inhibitory control (commission errors and false reaction time), completed a questionnaire on drinking-related self-control, and reported drinking behavior. Results Although the training was feasible and accepted by participants, it did not affect self-control over drinking, inhibitory control or drinking behavior. The relationship between session number and false reaction time was linear for alcohol stimuli, but squared for neutral stimuli. Conclusion Although our findings have to be interpreted in the light of some shortcomings, they demonstrate that further research is needed to enhance our understanding of how to improve inhibitory control and which factors might moderate this process.

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“…Much of the work on stress and reward (such as the work on cue-induced reinstatement) cannot distinguish between Pavlovian and instrumental processes. In humans, high anxiety levels (not experimentally induced) have been associated with deficits in SO-PIT (Quail, Morris et al 2017), whereas experimentally induced stress just prior to testing has been shown to promote SO-PIT (Pool, Brosch et al 2015) and to not alter SS-PIT (Steins-Loeber, Lörsch et al 2020). In rodents, acute stress just prior to testing has been shown not to affect SO-PIT expression (Pielock, Braun et al 2013), but to transiently block SS-PIT expression (Morgado, Silva et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Persistent effects of acute trauma on Pavlovian-to-instrumental transfer

Derman

Lattal

2022

Preprint

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In humans, an acutely traumatic experience can lead to post-traumatic stress disorder (PTSD), which is often characterized by changes in anxiety and motivation months after trauma. There are few demonstrations of the persistent motivational effects of an acute stressor in rodent approaches to PTSD. In two experiments, we evaluated the persistent effects of a battery of footshocks in one context on appetitive Pavlovian conditioning, instrumental learning, and Pavlovian-to-instrumental transfer (PIT) in a different context. A battery of footshocks before appetitive training caused deficits in single-outcome PIT in male Long Evans rats. The same battery of footshocks after appetitive training, but before testing had little effect on single-outcome PIT, but there were some qualitative deficits. Although males showed more generalized fear from the aversive to the appetitive context compared to females, there were no effects of shock on sensory-specific PIT in male or female rats. In general females showed less evidence for sensory-specific PIT compared to males, who showed robust sensory-specific PIT, with clear extinction and spontaneous recovery of the sensory-specific PIT effect across test sessions. These findings show that (a) an acute trauma can have persistent effects on general motivational processes and (b) sensory-specific PIT is a useful approach for exploring sex differences in strategies for instrumental learning. We discuss implications for current approaches to stress and motivation in preclinical and clinical studies.

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Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders

Cited by 12 publications

References 61 publications

Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users

Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users

Pilot testing of an adaptive, individualized inhibitory control training for binge drinking: first evidence on feasibility, acceptance, and efficacy

Persistent effects of acute trauma on Pavlovian-to-instrumental transfer

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