Does 18F-FDG Uptake by Respiratory Muscles on PET/CT Correlate with Chronic Obstructive Pulmonary Disease?

Osman, Medhat; Tran, Isaac; Muzaffar, Razi; Parkar, Nadeem; Sachdeva, Ashutosh; Ruppel, Gregg

doi:10.2967/jnmt.111.089961

Cited by 21 publications

(13 citation statements)

References 13 publications

(9 reference statements)

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“…A detailed analysis of the echographic findings may also be useful in the early diagnosis of muscle fatigue (64,65). Moreover, some imaging techniques may even allow for an approximation to the metabolic status of the respiratory muscles in both COPD patients and healthy individuals (66,67).…”

Section: Imagingmentioning

confidence: 99%

Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction

et al. 2016

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Muscle dysfunction is frequently observed in chronic obstructive pulmonary disease (COPD) patients, contributing to their exercise limitation and a worsening prognosis. The main factor leading to limb muscle dysfunction is deconditioning, whereas respiratory muscle dysfunction is mostly the result of pulmonary hyperinflation. However, both limb and respiratory muscles are also influenced by other negative factors, including smoking, systemic inflammation, nutritional abnormalities, exacerbations and some drugs. Limb muscle weakness is generally diagnosed through voluntary isometric maneuvers such as handgrip or quadriceps muscle contraction (dynamometry); while respiratory muscle loss of strength is usually recognized through a decrease in maximal static pressures measured at the mouth. Both types of measurements have validated reference values. Respiratory muscle strength can also be evaluated determining esophageal, gastric and transdiaphragmatic maximal pressures although there is a lack of widely accepted reference equations. Non-volitional maneuvers, obtained through electrical or magnetic stimulation, can be employed in patients unable to cooperate. Muscle endurance can also be assessed, generally using repeated submaximal maneuvers until exhaustion, but no validated reference values are available yet. The treatment of muscle dysfunction is multidimensional and includes improvement in lifestyle habits (smoking abstinence, healthy diet and a good level of physical activity, preferably outside), nutritional measures (diet supplements and occasionally, anabolic drugs), and different modalities of general and muscle training.

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Section: Imagingmentioning

confidence: 99%

Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction

et al. 2016

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“…Jacene et al reported in a retrospective study of 61 smokers and 35 non-smokers that increased FDG uptake in intercostal muscles is significantly more frequently seen in smokers relative to non-smokers on PET/CT [53]. Similarly, other investigators have observed increased FDG uptake on PET images in thoracic and abdominal muscles as well as in the right heart in patients with COPD [54–57]. Coulson et al prospectively assessed 7 male ex-smokers with COPD and 7 male ex-smoker control patients without COPD using FDG-PET/CT, and reported that presence of COPD was associated with significantly increased aortic FDG uptake compared to controls [58].…”

Section: Discussionmentioning

confidence: 99%

A Study of the Feasibility of FDG-PET/CT to Systematically Detect and Quantify Differential Metabolic Effects of Chronic Tobacco Use in Organs of the Whole Body—A Prospective Pilot Study

et al. 2017

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Objective The aim of this study was to assess the feasibility of 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) to systematically detect and quantify differential effects of chronic tobacco use in organs of the whole body. Methods 20 healthy male subjects (10 non-smokers and 10 chronic heavy smokers) were enrolled. Subjects underwent whole-body FDG-PET/CT, diagnostic unenhanced chest CT, mini-mental state examination (MMSE), urine testing for oxidative stress and serum testing. Organs of interest (thyroid, skin, skeletal muscle, aorta, heart, lung, adipose tissue, liver, spleen, brain, lumbar spinal bone marrow, and testis) were analyzed from FDG-PET/CT images to determine their metabolic activities using standardized uptake value (SUV) or metabolic volumetric product (MVP). Measurements were compared between subject groups using 2-sample t-tests or Wilcoxon rank-sum tests as determined by tests for normality. Correlational analyses were also performed. Results FDG-PET/CT revealed significantly decreased metabolic activity of lumbar spinal bone marrow (MVPmean 29.8±9.7 cc vs. 40.8±11.6 cc, p=0.03) and liver (SUVmean 1.8±0.2 vs. 2.0±0.2, p=0.049), and increased metabolic activity of visceral adipose tissue (VAT) (SUVmean 0.35±0.10 vs. 0.26±0.06, p=0.02) in chronic smokers compared to non-smokers. Normalized VAT volume was also significantly decreased (p=0.04) in chronic smokers. There were no statistically significant differences in the metabolic activity of other assessed organs. Conclusions Subclinical organ effects of chronic tobacco use are detectable and quantifiable on FDG-PET/CT. FDG-PET/CT may therefore play a major role in the study of systemic toxic effects of tobacco use in organs of the whole body for clinical or research purposes.

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“…If another muscle is considered as the reference tissue for comparison, we can easily determine whether uptake is increased in the body muscles overall or only in the respiratory muscles, as a distinctive PET study finding. REPLY: Thank you for your interest in our article (1). You have brought up very good and valid points we would like to address.…”

Section: E T T E R S T O T H E E D I T O Rmentioning

confidence: 99%

Respiratory Muscle 18F-FDG Uptake

Gholamrezanezhad¹

2012

Journal of Nuclear Medicine Technology

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Does 18F-FDG Uptake by Respiratory Muscles on PET/CT Correlate with Chronic Obstructive Pulmonary Disease?

Abstract: Our study revealed a strong correlation between increased (18)F-FDG uptake by respiratory muscles and the presence of COPD.

Cited by 21 publications

References 13 publications

Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction

Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction

A Study of the Feasibility of FDG-PET/CT to Systematically Detect and Quantify Differential Metabolic Effects of Chronic Tobacco Use in Organs of the Whole Body—A Prospective Pilot Study

Respiratory Muscle 18F-FDG Uptake

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