Doença de Chagas - primeiro caso autóctone na Amazônia Ocidental - Amazonas - Brasil.

França, Menabarreto Segadilha; Frade, João Macias; Konasugawa, Kenia; Almeida, Flávio Barbosa de

doi:10.1590/1809-43921980104759

Cited by 15 publications

(8 citation statements)

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“…However, the fi rst report of acute CD occurred in 1980 in São Paulo de Olivença (24) while the fi rst report of an acute case in the state capital, Manaus, occurred in 1994 in the city's urban area (25) . Since then, there have been increasingly frequent records of acute and chronic cases, mainly in the countryside (17) (26) (27) (28) (29) (30) (31) (32) (33) (34) (35) (36) .…”

Section: Chagas Disease In the State Of Amazonasmentioning

confidence: 99%

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Barbosa

Ferreira

Arcanjo

et al. 2015

Rev. Soc. Bras. Med. Trop.

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27www.scielo.br/rsbmt I www.rsbmt.org.br Revista da Sociedade Brasileira de Medicina Tropical 48(Suppl I):27-33, 2015http://dx.doi. org/10.1590/0037-8682-0258-2013 Review Article ABSTRACT Chagas disease (CD) is a parasitic infection that originated in the Americas and is caused by Trypanosoma cruzi.In the last few years, the disease has spread to countries in North America, Asia and Europe due to the migration of Latin Americans. In the Brazilian Amazon, CD has an endemic transmission, especially in the Rio Negro region, where an occupational hazard was described for piaçaveiros (piassaba gatherers). In the State of Amazonas, the fi rst chagasic infection was reported in 1977, and the fi rst acute CD case was recorded in 1980. After initiatives to integrate acute CD diagnostics with the malaria laboratories network, reports of acute CD cases have increased. Most of these cases are associated with oral transmission by the consumption of contaminated food. Chronic cases have also been diagnosed, mostly in the indeterminate form. These cases were detected by serological surveys in cardiologic outpatient clinics and during blood donor screening. Considering that the control mechanisms adopted in Brazil's classic transmission areas are not fully applicable in the Amazon, it is important to understand the disease behavior in this region, both in the acute and chronic cases. Therefore, the pursuit of control measures for the Amazon region should be a priority given that CD represents a challenge to preserving the way of life of the Amazon's inhabitants.

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Section: Chagas Disease In the State Of Amazonasmentioning

confidence: 99%

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Barbosa

Ferreira

Arcanjo

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…However, the percentage of neutrophils was increased according to the ELISA data for Chagas disease serology. 17 , several studies were conducted to describe the prevalence 4,7 , acute outbreaks 5,18 and cardiomyopathies 6,14,19 associated with infection by T. cruzi.…”

Section: Seroepidemiological and Immunological Relationshipsmentioning

confidence: 99%

Piassaba palm extractivism as an associated factor with Chagas disease: seroprevalence and immunological profile in native inhabitants of the Central Amazonia, Brazil

2015

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“…In the State of Amazonas, CD cases have been reported since 1977 12 , starting with the first autochthonous case described in São Paulo de Olivença in 1979 13 and vectors described since 1919 with Matta´s 14 description of the Rhodnius brethesi. In 1971, the occurrence of T. cruzi from naturally infected triatomines, which were implicated in the transmission of the disease, was reported in the City of Manaus 15 .…”

Section: Article/artigomentioning

confidence: 99%

Serological survey for Chagas disease in the rural areas of Manaus, Coari, and Tefé in the Western Brazilian Amazon

Magalhães

Coelho

Maciel

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Deforestation, uncontrolled forest, human population migration from endemic areas, and the large number of reservoirs and wild vectors naturally infected by Trypanosoma cruzi promote the endemicity of Chagas disease in the Amazon region. Methods: We conducted an initial serological survey (ELISA) in a sample of 1,263 persons; 1,095 (86.7%) were natives of the State of Amazonas, 666 (52.7%) were male, and 948 (75.1%) were over 20 years old. Serum samples that were found to be reactive, indeterminate, or inconclusive by indirect immunofluorescence (IFI) or positive with low titer by IFA were tested by Western blot (WB). Serologically confirmed patients (WB) were evaluated in terms of epidemiological, clinical, ECG, and echocardiography characteristics. Results: Fifteen patients had serologically confirmed T. cruzi infection, and 12 of them were autochthonous to the state of Amazonas, for an overall seroprevalence of 1.2% and 0.9% for the state of Amazonas. Five of the 15 cases were males, and the average age was 47 years old; most were farmers with low education. One patient who was not autochthonous, having originated from Alagoas, showed right bundle branch block, bundle branch block, and anterosuperior left ventricular systolic dysfunction with an ejection fraction of 54%. Conclusions: The results of this study ratify the importance of monitoring CD cases in Amazonia, particularly in the state of Amazonas. Keywords: Chagas Disease. Serological Survey. Brazilian Amazon. RESUMOIntrodução: Na Amazônia, o desmatamento desordenado da floresta, as migrações populacionais humanas de áreas endêmicas e o grande número de reservatórios e vetores silvestres naturalmente infectados por Trypanosoma cruzi, favorece a endemicidade da doença de Chagas nessa região. Métodos: Foi realizado um inquérito sorológico inicial por ensaio imunoenzimático (ELISA), em uma amostra de 1.263 pessoas, 1.095 (86,7% ) as quais eram autóctones do Estado do Amazonas, 666 (52,7%) do sexo masculino, 948 (75,1%) com idade superior a 20 anos. As amostras de soro reativas, indeterminadas ou inconclusivas por imunofluorescência indireta (IFI) positivas ou com baixo título na IFI foram submetidas ao Western blot (WB). Os pacientes com sorologia confirmada (WB) foram avaliados do ponto de vista epidemiológico, clínico, eletro e ecocardiográfico. Resultados: Quinze pacientes tiveram sorologia confirmada para infecção por T. cruzi, 12 dos quais autóctones do Estado do Amazonas, com uma prevalência sorológica geral de 1,2% e de 0,9% para o Estado do Amazonas. Entre os 15 casos com sorologia positiva, cinco eram do sexo masculino, média de idade de 47 anos, baixa escolaridade e a maioria agricultores. Um paciente não autoctone, procedente de Alagoas, apresentou bloqueio de ramo direito, bloqueio divisional ântero-superior e disfunção sistólica ventricular esquerda com fração de ejeção de 54%. Conclusões:O resultado deste estudo reforça a importância do monitoramento de casos da doença de Chagas na Amazônia, em especial no Amazonas. Pa...

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Doença de Chagas - primeiro caso autóctone na Amazônia Ocidental - Amazonas - Brasil.

Cited by 15 publications

References 0 publications

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Piassaba palm extractivism as an associated factor with Chagas disease: seroprevalence and immunological profile in native inhabitants of the Central Amazonia, Brazil

Serological survey for Chagas disease in the rural areas of Manaus, Coari, and Tefé in the Western Brazilian Amazon

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