Abstract:Receptor tyrosine kinase is a large transmembrane protein family that is often deregulated to cause lung cancer. EGFR is a cell membrane receptor that is over-expressed in lung cancer with numerous active mutated genes. Pharmacologically active compounds were purified from methanolic leaf extract of Schefflera stellata (Geartn.) Baill. which shows the potent inhibitory effect on over-expressed EGFRs. FTIR analysis D4 and D5 shows the presence of different functional groups such as carboxylic acids, phenol, ami… Show more
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