Do younger women with elevated basal follicular stimulating hormone levels undergoing gonadotropin-stimulated intrauterine insemination cycles represent compromised reproductive outcomes?

Devranoğlu, Belgin; Özdamar, Özkan; Köle, Emre; Eken, Meryem; Bozdağ, Halenur; Döğer, Emek

doi:10.1016/j.ejogrb.2016.01.030

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Mean aFc was not a prognostic factor for pregnancy after iUi. 31 Hansen et al published a secondary analysis of a prospective, randomized, multicenter clinical trial including 900 couples with unexplained infertility who underwent iUi treatment, up to 4 cycles. ovarian stimulation was performed with clomiphene citrate, letrozole, or gonadotropins.…”

Section: Resultsmentioning

confidence: 99%

Unexplained infertility: live-birth's prognostic factors to determine the ART management

Ohannessian¹,

Loundou²,

Gnisci³

et al. 2017

Minerva Obstet Gynecol

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ensuring the existence and regularity of unprotected sexual intercourse. Depending on the country, recommended tests may be different. Nevertheless, all the societies of reproductive medicine agree with semen analysis, assessment of the integrity of the female genital tract and the absence of ovulation disorder. The assessment of ovarian reserve by day 3 serum a bout 48.5 million couples worldwide would be infertile in the word. 1 in France, 1 in 5 couple consults for infertility. 2 in 10% to 30% of couples with infertility, no etiology is identifiable, that is usually called unexplained infertility. [3][4][5][6][7] However, the diagnosis of unexplained infertility requires all the necessary diagnostic tests to exclude an etiology, after

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Section: Resultsmentioning

confidence: 99%

Unexplained infertility: live-birth's prognostic factors to determine the ART management

Ohannessian¹,

Loundou²,

Gnisci³

et al. 2017

Minerva Obstet Gynecol

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“…Since many factors influence IUI success, the purpose of this research was to find out predictive variables to achieve pregnancy. [27]. Regarding AFC, by their prospective study on the relationship of AFC to CPR, Erdem et al…”

Section: Discussionmentioning

confidence: 99%

What is the optimal protocol for Intrauterine Insemination (IUI)? A Mini Review and A Retrospective Study to Evaluate Effective Factors Influencing Pregnancy after IUI

Herrero²,

Zhu

et al. 2019

Preprint

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Background: Although it is well documented on the study of intrauterine insemination (IUI), the effectiveness of various factors on IUI treatment is inconsistent. The aim of this study is to investigate the various factors that influence IUI outcome and attempt to set up optimal protocol for IUI patients. Methods: This was a retrospective cohort study including1948 cycles (843 couples) that performed IUI between January 2012 and December 2013 in a single centre. Various factors that may affect IUI outcome were analyzed using chi-square. Moreover, we conducted multiple logistic regression to evaluate the main factors on the effects of IUI outcome. In addition, follicle growth and endometrial development relevant to conception were also assessed among protocols. Results: The clinical pregnancy rate (CPR) per cycle was 12.5% in the present study. Seven factors were identified to be associated significantly with CPR by multivariate logistic regression analysis: female age, type of infertility, ovarian stimulation protocol, preovulatory follicles, endometrial thickness, growing length of preovulatory follicle, post-washed total motile spermatozoa count (TMSC). Comparing with 11 days or less, more than 15 days for ovarian response and endometrial development before insemination induced a better success rate. Although ovarian stimulation with gonadotrophin or letrozole induced higher CPR when comparing to stimulation with clomiphene citrate or without stimulation, ovarian stimulation with letrozole was superior to gonadotrophin by its similar CPR to gonadotrophin but lower follicle number, without the risk of multiple pregnancy. Women younger than 41 years with elevated endometrial thickness inseminated with TMSC ≥ 4.0 million had better chance to obtain pregnancy. Number of treatment cycle was not a factor to affect CPR, with a stable CPR in the first four cycles. Conclusions: We conclude that women no more than 41 years old are suitable to perform at least 4 cycles of IUI before proceeding to IVF. The optimized IUI treatment requires ovarian stimulation with letrozole to induce one/two follicles and fertilize with four or more million motile spermatozoa and an elevated endometrium on day 15 or after in the cycle. Key words: infertility, intrauterine insemination, effective factors, clinical pregnancy rate.

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“…2 Obtener entre el 10% y el 20% de embarazos clínicos por ciclo es un rango aceptable para la IIU. 5 Muchos factores reportados han sido utilizados como predictores de éxito después de la IIU: la edad, 6 la estimulación ovárica, 7 la reserva ovárica de las mujeres 8 y los parámetros espermáticos. 4 Varios parámetros seminales y espermáticos se han correlacionado con el embarazo clínico después de la IIU incluyendo el número de espermatozoides móviles y el porcentaje de espermatozoides con morfología normal.…”

Section: Introductionunclassified

Calidad seminal e inseminación intrauterina: estudio retrospectivo

Calderón-Mendoza¹,

López²,

Giraldo³

et al. 2018

Urol Colomb

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Palabras Claves► espermatozoide ► inseminación intrauterina ► embarazo ► fertilidad ► factor masculino ResumenObjetivo El objetivo de este estudio fue evaluar los parámetros seminales en muestras seminales frescas y seleccionadas y determinar los factores que predicen el éxito de la inseminación intrauterina (IIU). Materiales y Métodos Todas las parejas que se sometieron a IIU se registraron retrospectivamente y se incluyeron un total de 419 ciclos. Las muestras de semen fueron seleccionadas usando el método swim-up. Resultados No se encontró un parámetro seminal que pueda ser considerado como predictor de embarazo. Después de la preparación de la muestra, hubo una mejoría en la movilidad espermática y una disminución en la concentración. Adicionalmente, una diferencia significativa en el volumen entre los individuos menores de 40 años y mayores de 40 años fue observada. Conclusión No existen parámetros seminales que puedan predecir el éxito de la inseminación, básicamente debido a que lograr un embarazo depende de muchos factores. Sin embargo, el procesamiento en el laboratorio mejora considerablemente la movilidad espermática de las muestras y la IIU tiene tasas de embarazo aceptables; por lo tanto, debe ser considerada como primera elección de tratamiento. AbstractObjective The aim of the study was to evaluate the sperm parameters in fresh and washed samples and define the factors for predicting success after intrauterine insemination (IUI). Materials and Methods All couples undergoing IUI were retrospectively enrolled, a total of 419 IUI cycles were included. Sperm samples were prepared using the swim-up.

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Do younger women with elevated basal follicular stimulating hormone levels undergoing gonadotropin-stimulated intrauterine insemination cycles represent compromised reproductive outcomes?

Cited by 4 publications

References 34 publications

Unexplained infertility: live-birth's prognostic factors to determine the ART management

Unexplained infertility: live-birth's prognostic factors to determine the ART management

What is the optimal protocol for Intrauterine Insemination (IUI)? A Mini Review and A Retrospective Study to Evaluate Effective Factors Influencing Pregnancy after IUI

Calidad seminal e inseminación intrauterina: estudio retrospectivo

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