Do we need a Global Virome Project?

Jonas, Olga; Seifman, Richard

doi:10.1016/s2214-109x(19)30335-3

Cited by 36 publications

(21 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This theory of spillover is the reference driving strategies for preventing and controlling emerging infectious diseases at the early stage. It is at the origin of the search for intermediate species and screening projects such as the Global Virome or PREDICT ( Carroll et al, 2018 ; Jonas and Seifman, 2019 ) which objectives are to identify potential zoonotic viruses circulating in the wild. In the COVID-19 context this intermediate species is supposed to make the link between bats, the putative original virus reservoir, and humans, the final recipient host.…”

Section: Why Is the Spillover Model Not Compatible With The Observed mentioning

confidence: 99%

Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model

Frutos

Gavotte

Devaux

2021

Infection, Genetics and Evolution

View full text Add to dashboard Cite

While the COVID-19 pandemic continues to spread with currently more than 117 million cumulated cases and 2.6 million deaths worldwide as per March 2021, its origin is still debated. Although several hypotheses have been proposed, there is still no clear explanation about how its causative agent, SARS-CoV-2, emerged in human populations. Today, scientifically-valid facts that deserve to be debated still coexist with unverified statements blurring thus the knowledge on the origin of COVID-19. Our retrospective analysis of scientific data supports the hypothesis that SARS-CoV-2 is indeed a naturally occurring virus. However, the spillover model considered today as the main explanation to zoonotic emergence does not match the virus dynamics and somehow misguided the way researches were conducted. We conclude this review by proposing a change of paradigm and model and introduce the circulation model for explaining the various aspects of the dynamic of SARS-CoV-2 emergence in humans.

show abstract

Section: Why Is the Spillover Model Not Compatible With The Observed mentioning

confidence: 99%

Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model

Frutos

Gavotte

Devaux

2021

Infection, Genetics and Evolution

View full text Add to dashboard Cite

show abstract

“…The Global Virome Project has been initiated with the objective of creating a global atlas of pathogenic viruses, with the specific objective of identifying spill-over events 3 4 . The project has not been without its critics, and is not yet close to providing evidence which can be translated into preparedness action 5 . This underscores the importance of preparedness of the health system to deal with dangerous pathogens and better control of endemic infections.…”

Section: Introductionmentioning

confidence: 99%

The 2019 novel coronavirus disease (COVID-19) pandemic: A review of the current evidence

et al. 2020

View full text Add to dashboard Cite

A novel coronavirus (nCoV) spillover event, with its epicenter in Wuhan, People's Republic of China, has emerged as a public health emergency of international concern. This began as an outbreak in December 2019, and till February 28, 2020, there have been 83,704 confirmed cases of novel coronavirus disease 2019 (COVID-19) globally, with 2,859 deaths, resulting in an overall case fatality rate of 3.41 per cent (95% confidence interval 3.29-3.54%). By this time (February 28, 2020) 58 countries or territories and one international conveyance (Diamond Princess Cruise Ship) were affected. As a part of the global response to manage and contain the pandemic, major emphasis was placed on generating research intelligence to guide evidence-based responses to contain the virus, which was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), owing to its genetic similarities with the SARS virus. This review summarizes the emerging evidence which can help guide the public health response, particularly in India. Key areas have been identified in which research needs to be conducted to generate critical intelligence for advising prevention and control efforts. The emergence of SARS-CoV-2 has once again exposed the weaknesses of global health systems preparedness, ability to respond to an infectious threat, the rapidity of transmission of infections across international borders and the ineffectiveness of knee-jerk policy responses to emerging/re-emerging infectious disease threats. The review concludes with the key learning points from the ongoing efforts to prevent and contain COVID-19 and identifies the need to invest in health systems, community-led response mechanisms and the need for preparedness and global health security.

show abstract

“…The evolution of the COVID-19 threat has given us a unique opportunity to introspect on the narrative of reactive response driven epidemic management vis-à-vis the need to develop proactive prediction systems which can pre-empt novel spillovers and emergence or re-emergence of dangerous pathogens 51 . Further, the trajectory at which the pandemic has progressed in different countries has been slightly different, which also drives the issue of identifying and contextualizing evidence to base policy on.…”

Section: One Health Approach and Emerging Infectious Disease Threatsmentioning

confidence: 99%

One Health, “Disease X” & the challenge of “Unknown” Unknowns

et al. 2021

View full text Add to dashboard Cite

Do we need a Global Virome Project?

Cited by 36 publications

References 6 publications

Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model

Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model

The 2019 novel coronavirus disease (COVID-19) pandemic: A review of the current evidence

One Health, “Disease X” & the challenge of “Unknown” Unknowns

Contact Info

Product

Resources

About