Do underlying cardiovascular diseases have any impact on hospitalised patients with COVID-19?

Abstract

ObjectivesAn outbreak of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has sickened thousands of people in China. The purpose of this study was to explore the early clinical characteristics of COVID-19 patients with cardiovascular disease (CVD).MethodsThis is a retrospective analysis of patients with COVID-19 from a single centre. All patients underwent real-time reverse transcription PCR for SARS-CoV-2 on admission. Demographic and clinical factors and laboratory data were reviewed and collected to evaluate for significant associations.ResultsThe study included 541 patients with COVID-19. A total of 144 (26.6%) patients had a history of CVD. The mortality of patients with CVD reached 22.2%, which was higher than that of the overall population of this study (9.8%). Patients with CVD were also more likely to develop liver function abnormality, elevated blood creatinine and lactic dehydrogenase (p<0.05). Symptoms of sputum production were more common in patients with CVD (p=0.026). Lymphocytes, haemoglobin and albumin below the normal range were pervasive in the CVD group (p<0.05). The proportion of critically ill patients in the CVD group (27.8%) was significantly higher than that in the non-CVD group (8.8%). Multivariable logistic regression analysis revealed that CVD (OR: 2.735 (95% CI 1.495 to 5.003), p=0.001) was associated with critical COVID-19 condition, while patients with coronary heart disease were less likely to reach recovery standards (OR: 0.331 (95% CI 0.125 to 0.880), p=0.027).ConclusionsConsidering the high prevalence of CVD, a thorough CVD assessment at diagnosis and early intervention are recommended in COVID-19 patients with CVD. Patients with CVD are more vulnerable to deterioration.

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“…Four studies were excluded due to unavailability of the full-text. Finally, 56 papers ( [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] ) entered into meta-analysis for primary outcomes (mortality and ICU admission) and 198 papers [ 16 , 18 , [21] , [22] , [23] , [24] , [25] , [26] ,…”

Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study

“…The clinical spectrum of COVID-19 appears to be wide, ranging from asymptomatic infection, mild to critically-ill cases (3)(4)(5)(6). Significant comorbidities such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs) were associated with developing severe and critical COVID-19 condition (7,8). In severe cases, patients can rapidly develop acute respiratory distress syndrome (ARDS), septic shock, and multiple organ dysfunction syndromes (9).…”

Risk factors for SARS-CoV-2 infection, hospitalisation, and death in Catalonia, Spain: a population-based cross-sectional study

“…Several studies in the Chinese population have reported that COVID-19 patients suffer from cardiovascular diseases, chronic respiratory diseases, and diabetes. [17][18][19] In Italy, COVID-19 patients with a concomitant cardiac disease had a poorer prognosis than those without cardiac involvement. 20 In contrast, several US studies have reported obesity as a recurrent clinical characteristic of COVID-19 inpatients, 16,21,22 which is likely because obesity is more prevalent in the US (~40%) than in other Western countries (e.g.…”