Background: Intradialytic hypotension (IDH) is a common and distressful complication of hemodialysis. It can cause uncomfortable symptoms for patients, lower dialysis efficiency, and result in vascular access thrombosis. Therefore, preventing this complication is essential. Aim: To evaluate the effects of cooling the dialysate and patient education on decreasing intradialytic hypotension. Design A Quasi-experimental study design was used. Methods A purposive 70 patients undergoing hemodialysis in a hospital in Egypt participated in the study. Tool I (Structured Interviewing Questionnaires Sheet) and Tool II (Intradialytic hypotension Assessment Sheet) were used to collect data. Interventions include educate patients some instructions help in decrease IDH. In addition, lower dialysate temperature. Results A statistically significant difference in the occurrence of intradialytic hypotension was observed between pre and post intervention during every hour of hemodialysis (p < 0.01). Also, more than half of the patients reported symptoms of intradialytic hypotension before intervention, including fatigue, sweating, cramps, and dizziness with a statistically significant difference from those after intervention (p = 0.001). Conclusion: As a result of the intervention done, the symptoms observed during dialysis and the prevalence of IDH decreased. Recommendations: Cooling the dialysate and educating patients instructions regarding diet and dealing with drugs can be routinely applied to prevent IDH in hemodialysis units.