Do the Health Claims Made for Morinda citrifolia (Noni) Harmonize with Current Scientific Knowledge and Evaluation of its Biological Effects

Gupta, Rakesh; Patel, Amit

doi:10.7314/apjcp.2013.14.8.4495

Cited by 25 publications

(21 citation statements)

References 35 publications

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“…All parts of the plant have been reported for therapeutic effects as antibacterial, antiviral, antifungal, antitumor, anthelmintic, analgesic, hypotensive, antiinflammatory, and enhance the immune effects [6][7]. Previous pharmaceutical study showed that, extract of noni fruits effectively inhibit gram-positive and gram-negative bacteria such as Staphylococcus aureus, Bacillus subtilis, Proteus morgaii, Pseudomonas, Escherichia coli [8][9] moreover, the plants also utilizes to control the groups of pathogen bacteria, such Salmonella and Shigella [10][11][12]. In addition research conducted by Saludes (2002), reported that noni has been found to kill Mycobacterium tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Anti-Tubercular Activity of Extract and Coumpounds of Noni (Morinda Citrifolia Linn)

Mauliku

Hendro

Saputro

et al. 2017

Int J Pharm Pharm Sci

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Objective: The study evaluated the anti-tubercular activity of crude extracts and active compounds which was isolated, purification and characterization from noni (Morinda citrifolia Linn) against Mycobacterium tuberculosis strains H37Rv. Methods:The crude extract of the noni fruits was macerated using ethanol (96%). Ethanol crude extracts were qualitatively screened to identify of the flavonoid, scopoletin, antraquinon and alkaloids using phytochemical fractionation by harborn method. The anti-tubercular activity of noni fruit and its combination were determined by the minimum inhibitory concentration (MIC) of the bacterial growth at various doses 10 mg/ml, 20 mg/ml, 30 mg/ml, and 40 mg/ml using agar well diffusion method. Statistical analysis was performed by analysis of variance. Results:Crude extract and active compounds of noni fruit such as flavonoid, scopoletin, antraquinon and alkaloids significantly work as antitubercular against Mycobacterium tuberculosis strain H37Rv at various doses (p value=0,000). Crude extract (59.00±60.513), alkaloids (64.83±49.356), anthraquinones (69.50±50.396), and flavonoid (72.92±58.728) showed the highest anti-tubercular activity in inhibiting the growth of Mycobacterium tuberculosis strain H37Rv compared to scopoletin (95.92±33.280) and the negative control (189.25±33.280). The minimum inhibitory concentration was found at a dose of 40 mg/ml. Conclusion:Crude extract of noni fruit was the most active anti-tubercular against Mycobacterium tuberculosis strains H37Rv. One can assume that noni fruit can be fruther researched to be used as adjuvant therapy for anti-tuberculosis drugs.

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Section: Introductionmentioning

confidence: 99%

Anti-Tubercular Activity of Extract and Coumpounds of Noni (Morinda Citrifolia Linn)

Mauliku

Hendro

Saputro

et al. 2017

Int J Pharm Pharm Sci

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“…Different parts of this plant used as antioxidant, anti-inflammatory, antihypertensive, antidiarrheal, antithrombotic, anticancerous, xanthine oxidase (XO) inhibitory and hypoglycemic, etc. [4,5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Xanthine Oxidase Inhibitory Activity by Flavonoids From Pongamia Pinnata Linn

Bambrana

Sheela

2017

Asian J Pharm Clin Res

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Objective: Flavonoids from the crude seeds extract of Pongamia pinnata L., dried fruit powder of Morinda citrifolia L., bark of Mangifera indica L., and rhizome of Zingiber officinale Rosc. were screened for xanthine oxidase (XO) inhibition at different concentration. The inhibitory potential of quercetin and allopurinol were used for the determination of 50% inhibitory concentration (IC 50 ) and K i values.Methods: Isolation of flavonoids from the plant extracts was processed by column chromatography and tested for XO inhibitory activity in the range of 6-800 µg/ml. Results:The results demonstrated that optimized flavonoids extract of P. pinnata L. exhibited promising XO inhibition. P. pinnata L., M. indica L., and Z. officinale Rosc. had IC 50 in the concentration of 8.74 mM, 1.09 mM, 5.4 mM and Ki 0.35 mM, 1.73 mM, 2.7 mM, respectively. Conclusion:The study showed that plant species under investigation exhibited XO inhibition by optimized flavonoid extract. P. pinnata L. indicated promising XO inhibition compared to other plant extracts. Flavonoids can be used as a potent inhibitor of XO an alternative to allopurinol.

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“…Aerial parts of this plant are commonly used in folk medicine as antibacterial, antiviral, antifungal, antitumoral, anthelmintic, contra-ceptive, hypotensive, antiinflammatory, antioxidant, immunomodulating (Nayak and Shettigar, 2010), as well as antidopaminergic and antiadrenergic (Pandy et al, 2014). Moreover, its fruit has medicinal effects on allergy, arthritis, asthma, bacterial infections, cancer, diabetes, hypertension, menstrual disorders, obesity, gastric ulcers, headaches, sexual inhibition, insomnia, depression, stress, respiratory problems, AIDS, multiple sclerosis and drug dependency (Selvam et al, 2009;Gupta and Patel, 2013;Murata et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Toxicogenetic profile of rats treated with aqueous extract from Morinda citrifolia fruits

Moraes¹,

Alencar²,

Islam³

et al. 2016

J. Med. Plants Res.

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Morinda citrifolia ((Family: Rubiaceae)) is extensively used in traditional medicine due to its antiinflammatory, antimicrobial, antitumoral, and anti-hypertensive activities. However, there is no substantial data about hepatotoxic and toxicogenetic effects. This study evaluated biochemical changes and hepatotoxic, genotoxic, and mutagenic effects of aqueous extract of the fruit of M. citrifolia (AEMC) in liver, bone marrow, and peripheral blood cells. Animals (Rattus novergicus, 5 males and 5 females) were divided into negative control, positive control (Cyclophosphamide 25 mg/kg), and AEMC (2.5, 5, and 10 mg/kg, by gavage). AEMC induced increase of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), especially at 10 mg/kg in female (174.8 ± 50.7, 221.4 ± 24.6, and 174.7 ± 14.3 U/L) and male (156.5 ± 21.6, 183.7 ± 21.5, and 147.3 ± 17.8 U/L) (p<0.05). Histological analysis of livers showed inflammatory cell infiltration, nuclear fragmentation, microvacuolization, cellular swelling, points of inflammatoy necrosis, and discrete microvesicular steatosis. DNA damage in hepatocytes was found in both genders, mainly at 10 mg/kg (Frequency of Damage: 78.1 ± 4.5 and 70.4 ± 7.3%; Index of Damage: 107.6 ± 14.2 and 136.0 ± 26.9 for male and female, respectively). Similar results were observed in bone marrow cells. The AEMC 5 and 10 mg/kg induced micronucleus formation (4.4 ± 0.8 and 7.8 ± 1.1; 7.4 ± 1.1 and 9.6 ± 1.4 for peripheral blood and bone marrow cells, respectively) (p<0.05). These findings suggest clastogenic and/or aneugenic effects and genetic instability activated by AEMC, indicating precaution regarding the consumption of formulations or folk preparations based on this plant.

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Do the Health Claims Made for Morinda citrifolia (Noni) Harmonize with Current Scientific Knowledge and Evaluation of its Biological Effects

Cited by 25 publications

References 35 publications

Anti-Tubercular Activity of Extract and Coumpounds of Noni (Morinda Citrifolia Linn)

Anti-Tubercular Activity of Extract and Coumpounds of Noni (Morinda Citrifolia Linn)

Evaluation of Xanthine Oxidase Inhibitory Activity by Flavonoids From Pongamia Pinnata Linn

Toxicogenetic profile of rats treated with aqueous extract from Morinda citrifolia fruits

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