2014
DOI: 10.1159/000365195
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Abstract: A profound debate exists on the relationship between neurodegeneration and the innate immune response in humans. Although it is clear that such a relation exists, the causes and consequences of this complex association remain to be determined in detail. Drosophila is being used to investigate the mechanisms involved in neurodegeneration, and all genomic studies on this issue have generated gene catalogues enriched in genes of the innate immune response. We review the data reported in these publications and pro… Show more

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Cited by 13 publications
(11 citation statements)
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“…Increasing evidence suggests a critical role of chronic intestinal inflammation to PD pathogenesis 34 . It has also been hypothesized that activation of innate immune genes could play a neuroprotective role 35 . Altogether, these findings demonstrate that dysregulation of immune pathways in Drosophila also can contribute to neurodegeneration, as in mammals.…”
Section: Introductionmentioning
confidence: 99%
“…Increasing evidence suggests a critical role of chronic intestinal inflammation to PD pathogenesis 34 . It has also been hypothesized that activation of innate immune genes could play a neuroprotective role 35 . Altogether, these findings demonstrate that dysregulation of immune pathways in Drosophila also can contribute to neurodegeneration, as in mammals.…”
Section: Introductionmentioning
confidence: 99%
“…Drosophila is a powerful model for investigating fundamental aspects of neurodegeneration and glial responses to neural damage (Ayaz et al, 2008; Cantera and Barrio, 2015; Etchegaray et al, 2016; Fang and Bonini, 2012; Freeman et al, 2003; Kato et al, 2011; Lee and Sun, 2015; Logan and Freeman, 2007; Liu et al, 2015; Mishra et al, 2013; Rooney and Freeman, 2014; Ugur et al, 2016). Axotomy in adult flies elicits glial reactions that share many cellular hallmarks with mammalian glia responding to neurodegeneration, including altered morphology and increased phagocytic function (Kurant 2011; Logan and Freeman, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…the induction of antimicrobial peptides [4], the activation of the IMD pathway [5], antimicrobial autophagy [6] and host responses in epithelial barriers [7] are in line with these findings, supporting the concept that many principles of innate immunity in the animal kingdom originated very early on and have an important function in vertebrates still today. This also applies to the article by Cantera and Barrio [1], who present convincing evidence that in neurodegenerative processes, it is not only that the same immune genes are employed in Drosophila and Homo sapiens , but also that the transcription of these genes is regulated in a similar manner. It is therefore not surprising that the authors conclude that Drosophila can be used as an instrumental model to elucidate the role of immune response as regulators of neuroprotection.…”
mentioning
confidence: 66%
“…In this issue of the Journal of Innate Immunity , Rafael Cantera and Rosa Barrio [1 ]describe the relationship between neurodegeneration and innate immune responses in humans by referring to studies on Drosophila . At first glance, when reading the title and the abstract of the review, the reader may wonder whether the authors' conclusions are fictional.…”
mentioning
confidence: 99%