Do Safe and Effective Treatment Options Exist for Patients With Active Pemphigus Vulgaris Who Plan Conception and Pregnancy?

Pregnancy‐triggered pemphigus vulgaris with favorable fetal outcomes: A case report

“…Like other corticosteroids, prednisolone can cross placenta and increase the risk of premature birth, infection, and mortality if used in high doses. 9 In our case, although prednisolone was tapered to low doses after the patient recovered considerably, premature rupture of membranes resulted in premature birth. Premature birth in our case could be a result of prednisolone therapy or triggered by other factors including the gynecological history of the patient.…”

“…Prednisolone with low maintenance dosage is considered as first line of treatment. Like other corticosteroids, prednisolone can cross placenta and increase the risk of premature birth, infection, and mortality if used in high doses 9 . In our case, although prednisolone was tapered to low doses after the patient recovered considerably, premature rupture of membranes resulted in premature birth.…”

Pregnancy‐triggered pemphigus vulgaris with favorable fetal outcomes: A case report

“…Like other corticosteroids, prednisolone can cross placenta and increase the risk of premature birth, infection, and mortality if used in high doses. 9 In our case, although prednisolone was tapered to low doses after the patient recovered considerably, premature rupture of membranes resulted in premature birth. Premature birth in our case could be a result of prednisolone therapy or triggered by other factors including the gynecological history of the patient.…”

“…Prednisolone with low maintenance dosage is considered as first line of treatment. Like other corticosteroids, prednisolone can cross placenta and increase the risk of premature birth, infection, and mortality if used in high doses 9 . In our case, although prednisolone was tapered to low doses after the patient recovered considerably, premature rupture of membranes resulted in premature birth.…”

Pemphigus vulgaris in pregnancy: Analysis of current data on the management and outcome

“…On the other hand, an adequate control of the disease is required before conception as it is expected that pregnancy can aggravate pre-existing PV as it does in other autoimmune diseases. However Lehman et al 13 believe that adverse pregnancy outcome is more closely related to poor control of maternal disease and high titres of pemphigus antibodies. Corticosteroids are the first choice of treatment for PV.…”

Pregnancy outcome after rituximab treatment before conception in patients affected by severe pemphigus vulgaris/superficialis

“…1 However, a handful of neonatal cases have been described, most of them presenting with severe mucosal involvement. [2][3][4][5][6][7][8] We report an additional case of neonatal LABD with life-threatening respiratory tract manifestations.…”

Pregnancy‐triggered pemphigus vulgaris with favorable fetal outcomes: A case report

“…Like other corticosteroids, prednisolone can cross placenta and increase the risk of premature birth, infection, and mortality if used in high doses. 9 In our case, although prednisolone was tapered to low doses after the patient recovered considerably, premature rupture of membranes resulted in premature birth. Premature birth in our case could be a result of prednisolone therapy or triggered by other factors including the gynecological history of the patient.…”

“…Prednisolone with low maintenance dosage is considered as first line of treatment. Like other corticosteroids, prednisolone can cross placenta and increase the risk of premature birth, infection, and mortality if used in high doses 9 . In our case, although prednisolone was tapered to low doses after the patient recovered considerably, premature rupture of membranes resulted in premature birth.…”

Pemphigus vulgaris in pregnancy: Analysis of current data on the management and outcome

“…On the other hand, an adequate control of the disease is required before conception as it is expected that pregnancy can aggravate pre-existing PV as it does in other autoimmune diseases. However Lehman et al 13 believe that adverse pregnancy outcome is more closely related to poor control of maternal disease and high titres of pemphigus antibodies. Corticosteroids are the first choice of treatment for PV.…”

Pregnancy outcome after rituximab treatment before conception in patients affected by severe pemphigus vulgaris/superficialis

“…1 However, a handful of neonatal cases have been described, most of them presenting with severe mucosal involvement. [2][3][4][5][6][7][8] We report an additional case of neonatal LABD with life-threatening respiratory tract manifestations.…”

Pregnancy‐triggered pemphigus vulgaris with favorable fetal outcomes: A case report

“…Like other corticosteroids, prednisolone can cross placenta and increase the risk of premature birth, infection, and mortality if used in high doses. 9 In our case, although prednisolone was tapered to low doses after the patient recovered considerably, premature rupture of membranes resulted in premature birth. Premature birth in our case could be a result of prednisolone therapy or triggered by other factors including the gynecological history of the patient.…”

“…Prednisolone with low maintenance dosage is considered as first line of treatment. Like other corticosteroids, prednisolone can cross placenta and increase the risk of premature birth, infection, and mortality if used in high doses 9 . In our case, although prednisolone was tapered to low doses after the patient recovered considerably, premature rupture of membranes resulted in premature birth.…”

Pemphigus vulgaris in pregnancy: Analysis of current data on the management and outcome

“…On the other hand, an adequate control of the disease is required before conception as it is expected that pregnancy can aggravate pre-existing PV as it does in other autoimmune diseases. However Lehman et al 13 believe that adverse pregnancy outcome is more closely related to poor control of maternal disease and high titres of pemphigus antibodies. Corticosteroids are the first choice of treatment for PV.…”

Pregnancy outcome after rituximab treatment before conception in patients affected by severe pemphigus vulgaris/superficialis

“…1 However, a handful of neonatal cases have been described, most of them presenting with severe mucosal involvement. [2][3][4][5][6][7][8] We report an additional case of neonatal LABD with life-threatening respiratory tract manifestations.…”