Do high levels of folic acid in women’s blood impact the outcome of IVF?

Polzikov, M. A.; Блинов, Д. В.; Ushakova, T. I.; Barakoeva, Z. B.; Vovk, Lyudmila; Ovchinnikova, M. M.; Fetisova, Ju. A.; Николаева, Е. В.; Николаев, А. А.; Sergeyev, Oleg

doi:10.17749/2313-7347.2019.13.4.313-325

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…В исследовании, проведенном на субфертильных женщинах, было продемонстрировано, что вероятность забеременеть была на 16 % выше в группе, принимавшей поливитаминную добавку с 400 мкг/сут фолиевой кислоты, по сравнению с группой, принимавшей плацебо [70]. Cтоит отметить, что высокие уровни фолиевой кислоты связаны с худшими исходами беременности после ЭКО, о чем свидетельствуют результаты ряда проведенных исследований [71,72]; именно поэтому важно не допускать ее избытка (не использовать препараты с 800 мкг, 5 мг и т. п.…”

Section: • Vol 18 • № 1 Obstetrics Gynecology and Reproductionunclassified

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The role of epigenetics in male and female infertility

Egorova,

Derezina,

Chebanyan

et al. 2024

Akušerstvo, ginekologiâ i reprodukciâ

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Introduction. Today, infertility is a global problem that affects about 48.5 million married couples worldwide. It has been suggested that epigenetic aberrations are of great importance for reproductive health, as they account for an interactive relationship between genomic landscape, interplay with gene environment and disease phenotype. A new understanding on etiology of complex non-Mendelian disease traits has aroused a growing interest in reproductive epigenetics.Aim: to analyze available publications on epigenetic aspects of male and female infertility as well as nutrition-related risk factors.Materials and Methods. There was conducted a search for publications in the electronic databases PubMed, Google Scholar and Library to be selected in accordance with PRISMA recommendations. All relevant articles published before November 2023 were included in this review. As a result of the search, there were extracted 530 publications from PubMed, 57 publications – from eLibrary and 23 publications – from Google Scholar. Duplicates and non-full-text article versions were excluded.Results. Environmental factors play an important role in generation and maintenance of epigenetic marks. DNA methylation abnormalities can lower human fertility. Altered protamine level may affect epigenetic paternally transmitted DNA information. Long-term infertility is associated with a modified methylome in euploid blastocysts primarily affecting regulation of genomic imprinting. Both excess and deficiency of trace elements are associated with adverse pregnancy outcomes, similarly applied infertility.Conclusion. Despite that epigenetic mechanisms, genes, nutrition and dietary supplements discussed here affect infertility, while a relevant recommended dose has not yet been determined, it was noted that such parameters may positively influence fertility. However, more comprehensive and longitudinal human studies are required to examine their relationship to male and female reproductive functions.

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Section: • Vol 18 • № 1 Obstetrics Gynecology and Reproductionunclassified

“…Akusherstvo, Ginekologia i Reprodukcia = Obstetrics, Gynecology and Reproduction. 2024;18(1): [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82]. https://doi.…”

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The role of epigenetics in male and female infertility

Egorova,

Derezina,

Chebanyan

et al. 2024

Akušerstvo, ginekologiâ i reprodukciâ

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Regulatory restrictions on the use of valproate in girls and women of childbearing potential: status update

Блинов

Акарачкова

Цибизова

et al. 2021

Èpilepsiâ paroksizmalʹnye sostoâ.

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In 2019, some restrictions for use of valproic acid in women with reproductive potential by regulatory authorities and the original drug manufacturer based on the results of studies in real clinical practice were introduced. During 2019–2021, there were a further clinical data accumulation and labeling changes. The review presents a critical analysis of the changes in prescribing information and product label. There is a long lead time from the moment when safety data become known to the moment when changes are made to the medicinal product label and patient brochures. Some of the changes, including the need for high doses of folic acid to prevent neural tube defects, are debatable. Repealing the provision for mandatory archiving of informed consent forms for valproic acid use in girls and women raises legal risks. Improvements in pregnancy prevention programs and further research on the safety of valproic acid in real-world clinical settings are needed.

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An observational study «FOLLITROPIN» comparing the efficacy of follitropin alpha biosimilar: the real-world data

Kamilova¹,

Ovchinnikova²,

Ablyaeva³

et al. 2021

Akušerstvo, ginekologiâ i reprodukciâ

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Introduction. The efficacy and safety of biosimilar follitropin alpha have been demonstrated in randomized, blinded, prospective clinical trials of phases I and III. Unfortunately, there is a gap between the clinical trials and real clinical practice data. The real-world patient data helps to create an evidence-based background for successful implementation of a medicine at everyday practice in a nonselected population.Aim: to investigate the efficacy of follitropin alpha biosimilar therapy (Primapur®) in nonselected real-world population.Materials and Methods. A retrospective observational anonymized cohort study of follitropin alpha biosimilar as a pre-filled pen injector with a dose adjustment of 5 IU (Primapur®), aimed at investigate its efficacy and safety in a nonselected population with indications to assisted reproductive technologies (ART). The ovarian stimulation (OS) protocols included: monotherapy protocols with using only Primapur®; mixed protocols (recombinant and urinary-derived gonadotropins); short protocols with using antagonists gonadotropin-releasing hormone (GnRH) antagonist and long protocols with GnRH agonists. The stimulation protocols analyzed where Primapur® was applied for at least 5 days.Results. The overall clinical efficacy of ovarian stimulation cycles (N = 5484) was: oocytes retrieved – 9.5 ± 7.2, mature (MII) – 6.8 ± 6.6, fertilized (2PN) – 6.1 ± 5.8, clinical pregnancy per ET (PR) – 38.4 %. Mixed gonadotropin protocols (N = 2625) vs. monotherapy with Primapur® (N = 2859): oocytes retrieved – 8.6 ± 6.8 vs. 10.3 ± 7.4 (p < 0.001), mature (MII) – 6.7 ± 6.2 vs. 7.7 ± 6.9 (p < 0.001), fertilized (2PN) – 5.8 ± 5.2 vs. 7.2 ± 6.2 (p < 0.001). There were statistically significant differences between oocyte yields in mixed vs. monotherapy protocols due to subgroup differences, including age, body mass index (BMI) and IVF/ICSI attempts. No statistically significant differences were found for PR: 39.3 % vs. 37.6 % (p = 0.314). Monotherapy protocols with GnRH antagonist OS (N = 2183) vs. GnRH agonist (N = 676) revealed: oocytes retrieved – 10.5 ± 7.5 vs. 9.6 ± 7.0 (p = 0.032), mature (MII) – 7.6 ± 6.9 vs. 6.7 ± 5.7 (p < 0.001), fertilized (2PN) – 7.3 ± 6.3 vs. 5.7 ± 5.0 (p < 0.001). There were statistically significant differences between BMI and IVF/ICSI attempts. No statistically significant differences were found for PR: 37.9 % vs. 35.9 % (p = 0.482). All medicines were well tolerated and no serious adverse reactions were reported.Conclusion. This was the largest retrospective observational study conducted in the field of fertility in Russia and involved 5484 ovarian stimulation protocols at 35 IVF clinics. The obtained results demonstrated similar clinical efficacy for follitropin alpha biosimilar Primapur® in different OS protocols in real clinical practice.

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Do high levels of folic acid in women’s blood impact the outcome of IVF?

Cited by 3 publications

References 12 publications

The role of epigenetics in male and female infertility

The role of epigenetics in male and female infertility

Regulatory restrictions on the use of valproate in girls and women of childbearing potential: status update

An observational study «FOLLITROPIN» comparing the efficacy of follitropin alpha biosimilar: the real-world data

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