Do hepatic-sided tumors require more extensive resection than peritoneal-sided tumors in patients with T2 gallbladder cancer? Results of a retrospective multicenter study

Lee, Woo Hyung; Jeong, Chi Young; Jang, Jae Yool; Kim, Young Hoon; Roh, Young Hoon; Kim, Kwan Woo; Kang, Sung-Hwa; Yoon, Myung Hee; Seo, Hyung Il; Yun, Sung Pil; Park, Jeong-Ik; Jung, Bo‐Hyun; Shin, Dong Hoon; Choi, Young Il; Moon, Hyung‐In; Chu, Chong Woo; Ryu, Je Ho; Yang, Kwangho; Park, Young Mok; Hong, Soon Chan

doi:10.1016/j.surg.2017.05.004

Cited by 45 publications

(39 citation statements)

References 23 publications

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“…There is no serosa on the hepatic aspect as the bladder is attached to the liver by connective tissue, which may facilitate tumor invasion by contiguity. Therefore, surgical management may vary depending on tumor location (22,23). Survival is not affected by liver resection in patients with T2…”

Section: Discussionmentioning

confidence: 99%

A retrospective analysis of patients with gallbladder cancer: surgical treatment and survival according to tumor stage

Alonso¹,

Marcacuzco²,

Nutu³

et al. 2018

Rev Esp Enferm Dig

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Section: Discussionmentioning

confidence: 99%

A retrospective analysis of patients with gallbladder cancer: surgical treatment and survival according to tumor stage

Alonso¹,

Marcacuzco²,

Nutu³

et al. 2018

Rev Esp Enferm Dig

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“…However, compared with T1, T3, and T4 GBC, the prognosis of T2 GBC is very heterogeneous and is difficult to predict. Recently, the heterogeneous prognosis of T2 GBC has been demonstrated to be related in part to its location; a T2 GBC on the peritoneal side has a better prognosis, while a tumor on the hepatic side has worse prognosis [ 1 , 2 , 3 , 4 , 5 , 6 ]. The newly published American Joint Committee on Cancer (AJCC), eighth edition has subdivided T2 GBC into two categories according to the location of the primary tumor: peritoneal side tumor (pT2a) and hepatic side tumor (pT2b) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The newly published American Joint Committee on Cancer (AJCC), eighth edition has subdivided T2 GBC into two categories according to the location of the primary tumor: peritoneal side tumor (pT2a) and hepatic side tumor (pT2b) [ 7 ]. Since Shindoh and colleagues reported that GBC on the peritoneal side is associated with a higher five-year survival rate than that on the hepatic side [ 1 ], the superior prognosis of T2a over T2b GBC has been reproduced in several studies [ 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Further, there is lack of evidence regarding the clinicopathological differences that affect the differences in survival and the appropriate surgical strategy. Shindoh and colleagues defined the location of the tumor histopathologically [ 1 ], while the other studies defined the tumor location radiologically [ 3 , 4 , 5 , 6 , 7 ]. The anatomical difference between peritoneal and hepatic sides of the gallbladder may contribute to the differences that affect survival, though further study is needed to confirm this.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Significance of Tumor Location in T2 Gallbladder Cancer: A Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) Database Analysis

Lee

Choi

Kim

et al. 2020

JCM

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Background: T2 gallbladder cancer (GBC) is subdivided into T2a and T2b by the American Joint Committee on Cancer (AJCC) 8th edition. However; there is a lack of evidence for the prognostic significance of tumor location and validation with large-scale studies is needed. The aims of this study were to investigate the clinical features and clinical outcomes of T2 GBC according to tumor location and determine the prognostic significance of tumor location and an appropriate surgical strategy. Methods: Between 2000 and 2014 the Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) database was used to identify and enroll a total 707 patients with pathologically diagnosed T2 GBC who underwent curative resection. Clinicopathological findings and long-term follow-up results were analyzed. Results: The incidence of lymph node metastasis in T2b was significantly higher than that of T2a tumors (37.9% vs. 29.5%, p = 0.032). The 5-year disease-specific survival of T2a was better than that of T2b tumors (74.8% vs. 65.4%, p = 0.019). There was no significant survival difference in T2a between extended cholecystectomy and simple cholecystectomy with lymph node dissection (81.8% vs. 73.7%, p = 0.361). However; there was a better survival trend for T2b tumor after extended cholecystectomy (71.7% vs. 59.3%, p = 0.057). Adjuvant chemotherapy was associated with improved survival for patients with lymph node metastasis in T2a (72.1% vs. 56.9; p = 0.022) and in T2b (68.2 vs. 48.5; p < 0.001). Multivariate analysis revealed that lymph node metastasis was the only significant poor prognostic factor (Hazard ratio 3.222; 95% confidential interval 1.960–4.489; p < 0.001). Conclusions: For T2 GBC; tumor location was not an independent prognostic factor. Lymph node metastasis was a significant poor prognostic factor and adjuvant chemotherapy should be considered for the patients with lymph node metastasis.

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“…However, the biggest limitation of that study was the number of cases it included. In 2017, a study with a larger sample size was reported (6). That study involved 6 centers (including 93 patients with T2b GBC and 99 patients with T2a), and it found that S4b+5 resection significantly improved the 5-year survival rate (80.3% vs. 30.0%, p = 0.032) for T2b GBC.…”

Section: Current Status Of S4b+5 Resectionmentioning

confidence: 99%

Improvement in the diagnosis and treatment of T2 gallbladder carcinoma is pivotal to improvement in the overall prognosis for this disease

Zhou

Wang

Quan

et al. 2019

BST

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Do hepatic-sided tumors require more extensive resection than peritoneal-sided tumors in patients with T2 gallbladder cancer? Results of a retrospective multicenter study

Cited by 45 publications

References 23 publications

A retrospective analysis of patients with gallbladder cancer: surgical treatment and survival according to tumor stage

A retrospective analysis of patients with gallbladder cancer: surgical treatment and survival according to tumor stage

Prognostic Significance of Tumor Location in T2 Gallbladder Cancer: A Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) Database Analysis

Improvement in the diagnosis and treatment of T2 gallbladder carcinoma is pivotal to improvement in the overall prognosis for this disease

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