2009
DOI: 10.1111/j.1365-2222.2008.03134.x
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Abstract: Allergic diseases are rare in areas with high helminth parasite exposure and common where helminth exposure is lacking or significantly reduced, such as urban areas of developing countries and industrialized nations. Studies suggest that helminths induce a systemic immuno-modulatory network, including regulatory T cells and anti-inflammatory IL-10, which might play a key role in the protection against the allergic phenotype. Here, we review the current cross-sectional, birth cohort, and intervention study evid… Show more

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Cited by 170 publications
(148 citation statements)
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“…Helminth parasites in particular are associated with a degree of protection from allergic reactivity [3,4]. However, due to the heterogeneity of human exposure and the diversity of helminth species, current evidence is not always consonant with a causal link between infection and reduction of allergy [2].…”
Section: Discussionmentioning
confidence: 96%
“…Helminth parasites in particular are associated with a degree of protection from allergic reactivity [3,4]. However, due to the heterogeneity of human exposure and the diversity of helminth species, current evidence is not always consonant with a causal link between infection and reduction of allergy [2].…”
Section: Discussionmentioning
confidence: 96%
“…What causes skin reactivity suppression in rural children? There is a large amount of studies showing lower SPT spread in children living in natural helminthiasis nidi [22]. Low SPT spread in this case is due to skin reactivity reduction.…”
Section: Trial Results and Discussionmentioning
confidence: 99%
“…Thus, development of hyperreactive respiratory symptoms during common bacterial and viral infections after a "silent" incubatory period suggests that microorganisms may manipulate host immunity, allowing themselves a "safe escape" for a few days to do that, before the production of eradicative IgA or IgG antibodies [22]. While common microorganisms induce hyperreactive/allergic respiratory symptoms after their reproduction, massive infestation with various geohelminths in equatorial regions is associated with suppression of respiratory symptoms and a lower prevalence of atopic pathologies despite the potent IgE induction [1,21,[23][24][25][26][27][28][29]. The negative correlation of infective agent survival to the concentration of specific IgG1 and IgA suggests that in vivo, Th2 profile may not simply be a host-chosen reaction only, but also the most efficient and beneficial humoral response during host-infection interaction [30][31][32][33].…”
Section: The Role Of Infections In the Respiratory Atopymentioning
confidence: 99%