Do endometriomas induce an inflammatory reaction in nearby follicles?

Opøien, Hans Kristian; Fedorcsák, Péter; Połeć, Anna; Stensen, Mette Haug; Åbyholm, Thomas; Tanbo, Tom

doi:10.1093/humrep/det087

Cited by 43 publications

(38 citation statements)

References 38 publications

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“…These data suggest that an EM might not affect the environment of follicle growth. This result agrees with a recent report, which showed no differences in cytokine concentrations in the FF from ovaries with or without an EM [24].…”

Section: Discussionsupporting

confidence: 94%

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Measurement of oxidative stress in the follicular fluid of infertility patients with an endometrioma

Nakagawa¹,

Hisano

Sugiyama³

et al. 2015

Arch Gynecol Obstet

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Section: Discussionsupporting

confidence: 94%

“…With most endometriomas, there is no evidence of increased cytokine concentration in the ipsilateral leading follicle. Infrequently, the concentration of inflammatory cytokines is increased in the FF [24].…”

Section: Discussionmentioning

confidence: 99%

Measurement of oxidative stress in the follicular fluid of infertility patients with an endometrioma

Nakagawa¹,

Hisano

Sugiyama³

et al. 2015

Arch Gynecol Obstet

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“…TNFa is a pro-inflammatory cytokine released by macrophages and its production can be induced by VEGF. It has a role in proliferation of granulosa cells and enhances its IL8 secretion (Kilic et al 2007, Opøien et al 2013. TNFa level is significantly higher in FF associated with poor quality oocytes and embryos (Wunder et al 2006).…”

Section: Cytokines In Human Ffmentioning

confidence: 99%

“…Therefore, it is thought that granulosa cell and theca cell IL8 secretion is associated with follicle growth, oocyte maturation and ovulation, rather than being solely the result of hormonal stimulation (Runesson et al 2000). IL8 seems to vary inversely with IL10, IL12 and TNFa, indicating that immune cells may interact with granulosa cell function (Opøien et al 2013). IL8 levels in FF are not associated with fertilization and implantation rates or IVF outcome (Gazvani et al 2000).…”

Section: Cytokines In Human Ffmentioning

confidence: 99%

Is there an immune modulating role for follicular fluid in endometriosis? A narrative review

et al. 2020

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Follicular fluid (FF) surrounds the granulosa cell–oocyte complex and is one of the mediating factors in the communication between the cells within the follicle. Literature reveals that human FF and its components are key factors to the success of natural fertilization. Among other substances, FF consists of multiple cytokines and immune cells, including interleukin 6 (IL6), IL12, sHLA-G, macrophages, NK cells and lymphocytes. Together, these cells and cytokines might influence the oocyte–granulosa–cell complex. Altered balances of immune content might be involved in changes on folliculogenesis, oocyte maturation, oocyte quality and ovulation. Furthermore, these altered balances are possibly involved in infertility associated with immune-mediated diseases such as endometriosis. The aim of this narrative review is to elaborate on the function and contents of FF and its immunological profile in patients with endometriosis. A comprehensive literature search was performed for the published literature on FF (immune) contents, FF function and FF content alterations in endometriosis patients. In FF of patients with endometriosis, elevated levels of macrophages and several cytokines have been reported. The role of specific immune cells in FF and a clarification of the biological mechanism in healthy women and endometriosis patients remain largely unknown. Future studies in this field will give us more insight in the role of FF immune cells and the effect of altered balances in patients with endometriosis.

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“…However, whether ovarian surgical interventions will reduce ovarian reserves and responsiveness to stimulation is still a controversial issue. Some studies have shown that endometriomas will not damage ovarian reserves[1] and rarely damages oocyte quality[2]. Moreover, the excision of endometriomas can improve the success rate of ART[3].…”

Section: Introductionmentioning

confidence: 99%

Weigh the pros and cons to ovarian reserve before stripping ovarian endometriomas prior to IVF/ICSI: A meta-analysis

Tao

Chen

et al. 2017

PLoS ONE

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PurposeTo explore the effects of conservative surgery for endometriomas on ovarian responsiveness during assisted reproductive technology (ART) and provide reproductive and gynecological doctors with a more reliable reference program for the treatment of endometriomas.MethodsA literature search was performed by searching the PubMed, Embase, Cochrane Library, Web of Science and Science Direct databases. Studies with inter- and intra-patient comparisons of ovarian responses and oocyte quality between operated and unoperated ovaries and that met the inclusion criteria were retrieved, and the data from the outcome measures were extracted and pooled for this meta-analysis.ResultsTwenty-one published studies (2649 ART cycles) were included. The total amount of gonadotropin (Gn) used (inverse variance (IV):0.48; 95% confidence interval (CI): [0.13, 1.82], P = 0.0007) was significantly increased in the women with endometriomas who had a history of cystectomy. The estrogen (E) level on the day of hCG administration (IV: -0.29; 95% CI: [-0.41, -0.17], P<0.00001), the number of mature or dominant follicles (IV: -1.17; 95% CI: [-1.51, -0.82], P<0.00001) and the total number of oocytes retrieved (IV: -1.78; 95% CI: [-2.38, -1.17], P<0.00001) were significantly decreased in the women with endometriomas who had a history of cystectomy. The duration of stimulation (IV: 0.02; 95% CI: [-0.09, 0.13], P = 0.77), the total number of formed embryos (IV: -0.06; 95% CI: [-0.17, 0.04], P = 0.25), the pregnancy rate(IV:0.98;95%CI[0.82,1.18], P = 0.83) and the live birth rate(IV:0.93;95%CI[0.70,1.23], P = 0.61)were not statistically different between the two groups. Similar intra-patient results were found in the number of mature or dominant follicles (IV: -0.88; 95% CI: [-1.25, -0.52], P<0.00001) and the total number of oocytes retrieved (IV: -3.48; 95% CI: [-4.77, -2.19], P<0.00001).ConclusionART might be a better therapeutic method for ovarian endometrioma-related infertility than cystectomy.

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Do endometriomas induce an inflammatory reaction in nearby follicles?

Cited by 43 publications

References 38 publications

Measurement of oxidative stress in the follicular fluid of infertility patients with an endometrioma

Measurement of oxidative stress in the follicular fluid of infertility patients with an endometrioma

Is there an immune modulating role for follicular fluid in endometriosis? A narrative review

Weigh the pros and cons to ovarian reserve before stripping ovarian endometriomas prior to IVF/ICSI: A meta-analysis

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