Do ANGPTL-4 and galectin-3 reflect the severity of coronary artery disease?

Goenka, Luxitaa; George, Melvin; Singh, Rajesh; Jena, Ajay Kumar; Seshadri, Deepika; Karunakaran, Vasanth; Elumalai, Dhandapani Vellala; Rani, Jamuna; Ilango, K.

doi:10.1177/1753944717723311

Cited by 7 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study indicated that ANGPTL8 concentration exhibited no significant difference between CAD group and non-CAD group [ 19 ] and ANGPTL8 levels were not a factor for CAD in the multivariate analysis [ 20 ], which is consistent with our results. No significant association was found between ANGPTL4 level and angiographically characterized coronary atherosclerosis and severity of CAD [ 21 , 22 ]. Consistent with previous reports, our study did not find a significant association between ANGPTL4 and CAD.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Role of Angiopoietin-Like Protein 3 in Evaluating Coronary Artery Disease in Patients with Obstructive Sleep Apnea

Yang

Jiao

et al. 2020

Cardiovasc Drugs Ther

View full text Add to dashboard Cite

Purpose Hyperlipidemia is the most important early atherosclerosis and coronary artery disease (CAD) indicator. Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 are lipid dysfunction markers that may be linked to CAD. We investigated whether these circulating ANGPTLs are associated with CAD in patients with obstructive sleep apnea (OSA). Methods A total of 327 individuals participated in this study: 221 patients with OSA and CAD, 50 patients with OSA alone, and 56 controls. The Gensini Score was used to assess the severity of CAD. Serum ANGPTL3, ANGPTL4, and ANGPTL8 were measured in all subjects using Human Magnetic Luminex Screening Assay. The independent association between levels of ANGPTLs and CAD was evaluated by multivariate regression analysis. Results Serum ANGPTL3 levels were significantly higher in patients suffering from OSA and CAD compared with patients having OSA alone (46.97 ± 13.89 vs 38.25 ± 15.94 ng/ml, P < 0.001). Univariate analysis demonstrated that ANGPTL3 was a risk factor for CAD (OR = 1.72/10 ng ANGPTL3, 95% CI, 1.29–2.28, P < 0.001). In addition, multivariate analysis revealed that ANGPTL3 was independently associated with the presence of CAD (OR = 1.74/10 ng ANGPTL3, 95% CI, 1.29–2.35, P < 0.001) even after adjusting for cofounding factors. Furthermore, circulating ANGPTL3 levels were positively associated with triglyceride (r = 0.16, P = 0.01) and total cholesterol (r = 0.14, P = 0.02) levels, while ANGPTL3 levels had no significant correlation with the severity of CAD. No significant associations were found between the levels of ANGPTL4 and ANGPTL8 and CAD even after adjusting for established risk factors. Conclusion Elevated levels of ANGPTL3 were independently associated with a higher likelihood of CAD in patients with OSA. It may be a novel biomarker for OSA patients at high risk of developing cardiovascular diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

The Clinical Role of Angiopoietin-Like Protein 3 in Evaluating Coronary Artery Disease in Patients with Obstructive Sleep Apnea

Yang

Jiao

et al. 2020

Cardiovasc Drugs Ther

View full text Add to dashboard Cite

show abstract

“…Moreover, the circulating level of Gal-3 was significantly higher in patients with a myocardial infarction (MI) than in healthy control subjects [ 12 ]. Whereas others [ 13 ] did not observe a significant difference in Gal-3 concentration between these groups of patients. Recently published data suggest that Gal-3 is an independent risk factor of a coronary artery disease occurrence [ 12 ].…”

Section: Introductionmentioning

confidence: 58%

“…There are limited data on this biomarker in the ACS population. In addition, some authors suggest that Gal-3 does not appear to have a promising role for assessing the severity of CAD [ 13 ]. Our present research revealed that in the study group of MI patients, the Gal-3 concentration was significantly higher than in the group of patients without symptomatic CAD.…”

Section: Discussionmentioning

confidence: 99%

Galectin-3 as the Prognostic Factor of Adverse Cardiovascular Events in Long-Term Follow up in Patients after Myocardial Infarction—A Pilot Study

Święcki

Sawicki

Knapp

et al. 2020

JCM

View full text Add to dashboard Cite

Galectin-3 (Gal-3) is a new independent risk factor in the development and severity of coronary artery disease (CAD). The aim of the study was to evaluate whether Gal-3 concentration has prognostic value and if it reflects the progression of atherosclerosis in carotid arteries in patients with CAD after acute myocardial infarction (AMI). The analysis included 110 patients who were hospitalized due to AMI, treated with primary coronary intervention (PCI) and further attended a follow-up visit, and 100 healthy volunteers. The Gal-3 concentration and carotid ultrasound were evaluated at baseline and on a follow-up visit. We found that the Gal-3 concentration in the group with hyperlipidemia decreased during the observation (10.7 vs. 7.9 ng/mL, p = 0.00003). Patients rehospitalized during follow up had higher concentration of Gal-3 in the acute phase of myocardial infarction (MI) (10.7 vs. 7.2 ng/mL, p = 0.02; 10.1 vs. 8.0 ng/mL, p = 0.002, respectively). In the group of patients who had none of the following endpoints: subsequent MI, PCI, coronary artery bypass grafting (CABG) or stroke, there was a decrease in Gal-3 concentration at the follow-up visit. Parameters affecting the frequency of a composite endpoint occurrence are: the presence of atheromatous plaque in the carotid artery (p = 0.017), Gal-3 (p = 0.004) and haemoglobin (p = 0.03) concentration. In multivariate analysis, only Gal-3 concentration higher than 9.2 ng/mL at discharge was associated with a nine-fold increase of risk of composite endpoint occurrence (p = 0.0005, OR = 9.47, 95% CI 2.60–34.45). A significant decrease in Gal-3 concentration was observed in the group of patients after AMI without the endpoint occurrence during observation.

show abstract

“…The current study results may propose that Gal-3 as a major inflammatory marker, can have a substantial role in the pathogenetic process of plaque disturbance and ACS. Compared to patients with normal CA, earlier studies reported significantly high Gal-3 concentrations among CAD cases (11,(15)(16)(17)(18)(19)(20)(21)(22) , CCS (17,23&24) , ACS (25) , NSTEMI (16,17&26) , STEMI (17,27&28) , and premature myocardial infarction (29) . On the other hand, compared to patients with CCS, earlier studies demonstrated that Gal-3 values were significantly greater among those with ACS (16,24,30&31) and STEMI (17) .…”

Section: Discussionmentioning

confidence: 94%

Correlation between coronary artery disease and Galectin 3 serum level: Angiographic based study

Osman,

Algamal,

Elshal

et al. 2024

Ain Shams Medical Journal

View full text Add to dashboard Cite

Background: Galectin 3 (Gal-3) has great impact on initiation and progression of atherosclerosis as a cardiovascular inflammatory marker. The role of Gal-3 in coronary artery disease (CAD) remains a subject of debate. CAD and atherosclerosis are an inflammatory process. Aim of the work: to evaluate Gal-3 concentrations among patients with CAD presented with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS).Patients and Methods: 252 individuals were divided into control group with normal coronary angiography and patient group with obstructive CAD which was further subdivided according to the clinical presentations into ACS and CCS subgroups. All groups were matched for age and sex.Results: significantly higher Gal-3 values were found in CAD group, ACS subgroup, and CCS subgroup versus control group. Gal-3 values were significantly higher in ACS subgroup compared with CCS subgroup. Gal-3 concentrations demonstrated a non-significant association with age and EF. Gal-3 levels showed significant positive relationship with Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score in CAD group, CCS subgroup, and ACS subgroup. Gal-3 concentrations demonstrated significant positive relationship with the number of stenotic coronary arteries and segments in CAD group and CCS subgroup but not in ACS subgroup. Gal-3 was found to significantly predict coronary artery disease.Conclusions: Gal-3 concentrations correlated with CAD's presence and severity. We recommend the integration of Gal-3 in the diagnostic, prognostic, and predictive modules of CAD.

show abstract

Do ANGPTL-4 and galectin-3 reflect the severity of coronary artery disease?

Abstract: In conclusion, ANGPTL-4 and galectin-3 do not appear to have a promising role for assessing the severity of CAD. Nevertheless these biomarkers do warrant further exploration in improving the management of CAD.

Cited by 7 publications

References 42 publications

The Clinical Role of Angiopoietin-Like Protein 3 in Evaluating Coronary Artery Disease in Patients with Obstructive Sleep Apnea

The Clinical Role of Angiopoietin-Like Protein 3 in Evaluating Coronary Artery Disease in Patients with Obstructive Sleep Apnea

Galectin-3 as the Prognostic Factor of Adverse Cardiovascular Events in Long-Term Follow up in Patients after Myocardial Infarction—A Pilot Study

Correlation between coronary artery disease and Galectin 3 serum level: Angiographic based study

Contact Info

Product

Resources

About