DNMT3B −579 G&gt;T Promoter Polymorphism and the Risk of Gastric Cancer in the West of Iran

Ahmadi, Kolsoum; Soleimani, Azam; Irani, Shiva; Kiani, Ali Asghar; Ghanadi, Koroush; Noormohamadi, Zahra; Sakinejad, Foroozan

doi:10.1007/s12029-017-9928-7

Cited by 12 publications

(4 citation statements)

References 32 publications

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“…This result is almost in agreement with the findings of a previous study which investigated the association of DNMT3B-579G>T polymorphism with gastric cancer in Iranian population (a frequency of 60.71% and 39.29% for G allele and minor allele, T, respectively, among controls). 21 These results also were relatively consistent with those revealed in European population (a frequency of 65.0% and 35.0% for G and T alleles, respectively, among controls). 20,27 However, the results of the present study were different from those observed in other Asian populations with a higher frequency of T allele than G allele for DNMT3B-579G>T polymorphism.…”

Section: Discussionsupporting

confidence: 90%

“…The results of a study conducted in a subset of Iranian patients with gastric cancer suggested that the DNMT3B-579T allele might increase the relative risk for the progression of clinicopathological characteristic of tumor grade in affected individuals. 21 Also, this allele showed a significant difference between patients with gastric cancer and control group in population of China. 22 There was no significant relationship between DNMT3B-579G>T and gallbladder carcinoma in Indian population.…”

Section: Discussionmentioning

confidence: 91%

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DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

Yazdanpanahi

Etemadifar

Shams

2019

CJN

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Background: Deoxyribonucleic acid (DNA) methyltransferase 3 beta (DNMT3B) gene encodes an MT enzyme involving in de novo methylation of DNA. The present investigation aimed to explore the association of DNMT3B-579G>T (rs1569686) polymorphism with multiple sclerosis (MS). Methods: 130 Iranian patients with MS and 130 controls were genotyped for the DNMT3B-579G>T using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: There was no statistically significant association between DNMT3B-579G>T and susceptibility to MS. The alleles and genotypes of DNMT3B-579G>T did not have different risks of MS development under various models [T vs. G (P = 0.86); GTvs. GG (P = 0.48); TT vs. GG (P > 0.99); GT+TT vs. GG (P = 0.60), and TT vs. GG+GT (P = 0.87)]. Also, there was no statistically significant association between genotypes and clinical and demographic characteristics of patients (P > 0.05). Conclusion: The current findings suggest that DNMT3B-579G>T is probably not a crucial potential risk marker in molecular diagnostics of MS among Iranian. However, to the best of our knowledge, this is the ﬁrst genetic association study about the DNMT3B polymorphisms and MS. Therefore, further surveys should be included to estimate the exact relevance of DNMT3B gene to the development of autoimmune disorders like MS.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 91%

DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

Yazdanpanahi

Etemadifar

Shams

2019

CJN

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“…However, there is conflicting evidence on the contribution of these two SNPs in different cancers [140][141][142][143]. Hu et al [144] and Chen et al [145] reported the association of rs1569686 with gastric cancer risk in the Chinese population, while Wang et al [146] and Ahmadi et al [147] did not observe any significant association in the Chinese and Iranian population, respectively. Likewise, other studies demonstrated that rs2424913 was irrelevant to the risk of gastric carcinogenesis [144][145][148][149][150].…”

Section: Polymorphisms In Dnmts and Gastric Cancer Developmentmentioning

confidence: 99%

DNA Methyltransferases and Gastric Cancer: Insight Into Targeted Therapy

et al. 2018

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Gastric cancer is a major health problem worldwide occupying most frequent causes of cancerrelated mortality. In addition to genetic modifications, epigenetic alterations catalyzed by DNA methyltransferases (DNMTs) is a well-characterized epigenetic hallmark in gastric cancer. The reversible nature of epigenetic alterations and central role of DNA methylation in diverse biological processes provides an opportunity for using DNA methyltransferase inhibitors to enhance the efficacy of chemotherapeutics. In this review, we discussed key factors or mechanisms such as SNPs, infections, and genetic modifications that trigger DNMTs level modification in gastric cancer, and their potential roles in cancer progression. Finally, we focused on how inhibitors of the DNMTs can most effectively be used for the treatment of gastric cancer with multidrug resistance.

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“…In this regard, serious life-threatening health difficulties are more likely among individuals with diabetes, which would significantly affect the therapeutic care cost, lower the quality of life and enhance mortality (5)(6)(7)(8). Evidence implies that the production of reactive oxygen species (oxidative stress) can exacerbate hyperglycemia and increase the risk of diabetes complications (microvascular or cardiovascular) (9).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Wet Cupping (Al-hijamah) and Limonene on Oxidative Stress and Biochemical Parameters in Diabetic Rats

Alizadeh

Nafari

Moradi

et al. 2022

Jundishapur J Nat Pharm Prod

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Background: According to the international diabetes federation, 629 million adults will suffer from diabetes by 2045. Wet cupping therapy is a combination of bleeding and dry cupping and has been used in traditional medicine as a complementary therapy for diabetes. Limonene was shown to have both antioxidant and antidiabetic activity but its potential alongside other treatments has not been thoroughly explored. Objectives: Although wet-cupping therapy is widely used under different conditions, its potential in the treatment of diabetes is not well-examined. Methods: Male Wistar rats were then injected with alloxan and nicotinamide to induce diabetes. After cupping, the rats’ serum nitric oxide, creatinine, SGPT, SGOT, cholesterol, triglyceride, glucose, GPX, urea, and HDL levels were determined. The glutathione, catalase, glutathione peroxidase, malondialdehyde, and protein level of the serum, renal, and liver were then measured. Results: The results showed a significant differences in serum glucose levels among the diabetic rats receiving wet cupping and limonene, in serum glutathione levels in diabetic rats receiving limonene or limonene and wet cupping compared to the diabetic rats, in liver GSH levels in control rats receiving limonene and wet cupping, in the liver GPX activity in control rats receiving limonene, and in liver catalase activity in control rats receiving limonene and wet cupping compared to control group. There was no significant change in serum NO, protein, creatinine, SGPT, SGOT, cholesterol, triglyceride MDA, urea, catalase, HDL, renal GSH, MDA, catalase, liver protein, and MDA Level. Conclusions: The findings of the present study suggested that a combination of limonene and wet cupping therapy could be presented as an agent to lower elevated blood glucose levels in diabetic rats. Further clinical studies are required to confirm the findings.

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DNMT3B −579 G>T Promoter Polymorphism and the Risk of Gastric Cancer in the West of Iran

Abstract: Our study suggested that the -579 T allele may increase the relative risk for the progression of clinicopathological characteristic of tumor grade of gastric cancer patients.

Cited by 12 publications

References 32 publications

DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

DNA Methyltransferases and Gastric Cancer: Insight Into Targeted Therapy

The Effect of Wet Cupping (Al-hijamah) and Limonene on Oxidative Stress and Biochemical Parameters in Diabetic Rats

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