W. David Wilson, Farial A. Tanious, Shaikh Mizan, Shijie Yao, Alexander S. Kiselyov, Gerald Zon, Lucjan Strekowski
Abstract:Triple-helical structures involving the interaction of an oligonucleotide third strand with a duplex nucleic acid sequence have recently gained attention as a therapeutic strategy in the "antigene" approach [cf. Helene, C. (1991) Eur. J. Cancer 27, 1466-1471]. This method utilizes the triple helix formed from the cellular duplex and an added third strand to directly regulate the activity of a selected gene. The limited stability of nucleic acid triple-helical interactions, particularly if the third strand has …
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