1993
DOI: 10.1021/bi00091a011 View full text |Buy / Rent full text
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Abstract: Triple-helical structures involving the interaction of an oligonucleotide third strand with a duplex nucleic acid sequence have recently gained attention as a therapeutic strategy in the "antigene" approach [cf. Helene, C. (1991) Eur. J. Cancer 27, 1466-1471]. This method utilizes the triple helix formed from the cellular duplex and an added third strand to directly regulate the activity of a selected gene. The limited stability of nucleic acid triple-helical interactions, particularly if the third strand has … Show more

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“…ld [16]. This compound increases the melting temperature of polydA-2polydT [16] and, at a concentration of 10/.tM, increases the binding of T,C, to the target sequence A6G6.C6T 6 by at least 100-fold [19]. The results with this compound are also presented in Fig.…”
Section: Resultsmentioning
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“…ld [16]. This compound increases the melting temperature of polydA-2polydT [16] and, at a concentration of 10/.tM, increases the binding of T,C, to the target sequence A6G6.C6T 6 by at least 100-fold [19]. The results with this compound are also presented in Fig.…”
Section: Resultsmentioning
“…We have also examined the ability of a triplex binding ligand ( Fig. ld) [16] to stabilise these structures.…”
Section: Introductionmentioning
“…1a) were the first molecules reported to strongly stabilize this latter type of triple helices even though they have a preference for T⅐AϫT stretches (16). Several other intercalators (17)(18)(19)(20) as well as various DNA minor groove ligands (21)(22)(23) have also been shown to bind to DNA triple helices. Intercalators usually stabilize to a greater extent triple helices containing T⅐AϫT triplets, whereas minor groove binders usually destabilize triplexes, except in a particular case where the triple helix involved an RNA strand (24).…”
Section: And References Therein)mentioning
“…An alternative strategy uses ligands which bind selectively to triplex (not duplex) DNA and which therefore perturb the equilibrium in the direction of triplex formation. Several such ligands have been described (reviewed in [14]) including 3-methoxy-7H-8-methyl-11[(3¢-amino)propylamino]-benzo [e]pyrido [4,3-b]indole 2 (BePI) and its derivatives [15][16][17][18], coralyne [19][20][21], naphthylquinoline derivatives [22][23][24][25][26] and bis-substituted amidoanthraquinones [27,28]. Although most studies with these compounds have examined their interaction with parallel triplets, they also stabilize the antiparallel motif [24,25,29].…”
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