2015
DOI: 10.18632/aging.100858
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Abstract: Cells are constantly exposed to endogenous and exogenous factors that threaten the integrity of their DNA. The maintenance of genome stability is of paramount importance in the prevention of both cancer and aging processes. To deal with DNA damage, cells put into operation a sophisticated and coordinated mechanism, collectively known as DNA damage response (DDR). The DDR orchestrates different cellular processes, such as DNA repair, senescence and apoptosis. Among the key factors of the DDR, the related protei… Show more

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Cited by 87 publications
(82 citation statements)
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References 180 publications
(171 reference statements)
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“…16 p53 is a major regulator of the cellular response to DNA damage, including expression of DNA repair genes, and induction of senescence and apoptosis. 17 Such mechanisms are certainly relevant to response of neural and endothelial cells in the retina and optic disc to radiation damage.…”
Section: Genetic Risk Factors For Radiation Vasculopathymentioning
confidence: 99%
“…16 p53 is a major regulator of the cellular response to DNA damage, including expression of DNA repair genes, and induction of senescence and apoptosis. 17 Such mechanisms are certainly relevant to response of neural and endothelial cells in the retina and optic disc to radiation damage.…”
Section: Genetic Risk Factors For Radiation Vasculopathymentioning
confidence: 99%
“…Mice without p53 died of cancer 100-250 days after birth, unlike p53-positive mice that lived 500 days or more (7,8). P63 plays a pivotal role in the skin development, and p73 in the development of the nervous and immune system (9). In addition, P63 -/-mice die soon after the birth due to dehydration associated with poor skin and epithelial tissue development (10).…”
Section: Vavrova Et Al: Dose-rate As a Critical Aspect Of Cellular Rmentioning
confidence: 99%
“…These TFs are also capable of direct modulation of DNA repair genes and proteins [146]. Moreover, the p53 family could also be linked to ageing at the organism level [146,160].…”
Section: Transcriptional and Post-transcriptional Regulators As Sirtumentioning
confidence: 99%
“…These TFs are also capable of direct modulation of DNA repair genes and proteins [146]. Moreover, the p53 family could also be linked to ageing at the organism level [146,160]. Other emerging roles of p53 in glucose and lipid metabolism, ROS signalling and oxidative stress [64] suggest a significant functional overlap with SIRT pathways.…”
Section: Transcriptional and Post-transcriptional Regulators As Sirtumentioning
confidence: 99%