2007
DOI: 10.1007/s10350-007-9013-6
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Abstract: Patients who undergo an aneuploid colorectal cancer surgical resection have a higher risk of death after five years. This finding may ultimately impact survival of patients with node-negative colon cancer through adjuvant therapy.

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Cited by 61 publications
(56 citation statements)
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“…4 Approximately 80% of all colorectal carcinomas show aneuploidy. 5 Cytogenetic and molecular cytogenetic analyses have revealed that tumor-specific gains and losses of entire chromosomes or chromosome arms are early genome mutations. [6][7][8][9] The genomic imbalances show a strikingly conserved recurrent pattern that is characteristic for colorectal carcinomas and is distinct from other solid tumors.…”
mentioning
confidence: 99%
“…4 Approximately 80% of all colorectal carcinomas show aneuploidy. 5 Cytogenetic and molecular cytogenetic analyses have revealed that tumor-specific gains and losses of entire chromosomes or chromosome arms are early genome mutations. [6][7][8][9] The genomic imbalances show a strikingly conserved recurrent pattern that is characteristic for colorectal carcinomas and is distinct from other solid tumors.…”
mentioning
confidence: 99%
“…[11][12][13] CIN is associated with aneuploid tumors; thus, ploidy serves as a surrogate marker for CIN in CRC. 11,12 Most previous studies on MSI status in patients with CRC have focused on survival and response to chemotherapy, for which recent data continue to produce equivocal results.…”
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confidence: 99%
“…[11][12][13] CIN is associated with aneuploid tumors; thus, ploidy serves as a surrogate marker for CIN in CRC. 11,12 Most previous studies on MSI status in patients with CRC have focused on survival and response to chemotherapy, for which recent data continue to produce equivocal results. [14][15][16][17][18][19] Conversely, few, if any, studies have investigated the effect of MSI status in CRC on recurrence patterns and survival among patients who were included in a strict surveillance program.…”
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confidence: 99%
“…Despite this clear demonstration of an association of aneuploidy and outcome the American Society of Clinical Oncology (ASCO) does not recommend ploidy assessment in clinical routine. In our opinion, this should be reconsidered, also because meta-analysis revealed results clearly indicating the prognostic impact of aneuploidy on colorectal and www.intechopen.com other cancers (Araujo et al 2007;Walther, Houlston, and Tomlinson 2008;Schulze and Petersen 2011). Overall, the assessment of nuclear aneuploidy by image cytometry could become routine practice to assist in predicting individual cancer risk and in disease prognostication in solid tumors.…”
Section: Discussionmentioning
confidence: 99%