DNA of Bovine IPV-Virus (BHV-1, IPV Strain) in the Sacral Ganglia of Latently Infected Calves

Ackermann, Markus; Wyler, R.

doi:10.1007/978-94-009-5662-9_13

Cited by 49 publications

(63 citation statements)

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“…The downmodulation of CD18 might be explained both by the changes in membrane fluidity and decreased PG synthesis. Our findings were partially supported by the observations of in vitro studies in which glucocorticosteroids were shown to decrease lymphocyte adhesion to the endothelium as well as intercellular interactions through the inhibition of LFA-1 and CD2 up-regulation and of the steady state mRNA levels of LFA-1 and CD2 genes production [29] resulting in the interference with lymphocyte recirculation patterns which could form one explanation for reduced specific immune responsiveness [1]. The significant though transient effect of DEX on CD18 expression at day 4 could involve LFA-1 down-modulation.…”

Section: Discussionsupporting

confidence: 80%

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

et al. 2004

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-Dexamethasone is a potent therapeutic for treatment of the fatty liver syndrome or primary ketosis in post partum dairy cows. Reservations exist, however, among practitioners with respect to the risk of immunosuppression induced by corticosteroids. The aim of this study was to investigate the effect of a single injection of dexamethasone-21-isonicotinate on distinct immune functions of postpartum dairy cows because only scarce information is available on the effects of corticosteroid preparations when administered at a dosage and frequency for treatment of the fatty liver syndrome or primary ketosis. Sixteen Swedish red-pied dairy cows, between days 9 and 15 post partum, were allotted to either a control group (n = 8) or a treatment group (n = 8). The cows in the treatment group received a single intramuscular injection of a dexamethasone-21-isonicotinate suspension at a dosage of 0.02 mg/kg i.m. at the start of the experiment. White blood cell counts and selected lymphocyte functions (lymphocyte proliferation, expression of lymphocyte markers and the β2 and α4 chain of adhesion molecules belonging to the integrin family) and some parameters of the energy metabolism (glucose, insulin) were determined before the administration of corticosteroids (day 0) and subsequently at days 2, 4, 7 and 9 of the experiment. Changes in glucose and insulin were within the target range for treatment of the fatty liver syndrome or primary ketosis. Significant (P < 0.05) increases in the number of circulating white blood cells were observed in treated cows on the second day following treatment which was exclusively caused by an increase in the number of circulating neutrophils. Lymphocyte blastogenesis in response to ConA and the percentages of lymphocytes positive for CD2, CD4, CD8, CD49d and CD18 as well as the intensity of CD49d expression did not differ between the treatment and control groups. There was, however, a significant reduction (P < 0.01) in the intensity of CD18 expression on lymphocytes in the treated animals on the fourth day after treatment. In conclusion, a single administration of dexamethasone-21-isonicotinate in a dosage of 0.02 mg/kg i.m. at two weeks post partum in healthy cows had a significant but highly transient effect on CD18 expression on lymphocytes and the number of peripheral blood neutrophils, but did not affect lymphocyte blastogenesis or lymphocyte subpopulation patterns in peripheral blood.

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Section: Discussionsupporting

confidence: 80%

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

et al. 2004

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“…Localization of infectious virus in the spleen further supports this assumption rather than a reactivation of latent virus, since during latency, BoHV-1 is known to be located in the trigeminal ganglia (Ackermann et al, 1982;Rock et al, 1986).…”

Section: Discussionmentioning

confidence: 75%

Virologic Investigations of Free-Living European Bison (Bison Bonasus) From the Bialowieza Primeval Forest, Poland

Borchers

Brackmann

Wolf

et al. 2002

Journal of Wildlife Diseases

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We conducted virologic investigations on postmortem specimens from 261 free-living European bison (Bison bonasus) from the Bialowieza Primeval Forest, Poland collected between 1990 and 2000. Fifty-four of 94 males had balanoposthitis; none of the 167 female bison examined had reproductive tract lesions. Peripheral blood, swabs, and various tissues were analyzed for bovine viruses as well as for viral DNA by bovine herpesvirus 1 (BoHV-1) and bovine herpesvirus 4 (BoHV-4) specific polymerase chain reaction (PCR) technique. An infectious bovine rhinotracheitis like BoHV-1 strain was isolated from the spleen of a female bison calf and additionally was detected by nested PCR from splenic tissue. None of the bison had significant antibody titers against BoHV-1, bovine herpesvirus 2, BoHV-4, caprine herpesvirus 1, cervid herpesvirus 1, or bovine viral diarrhea (BVD) virus-1. However, low antibody titers in two animals indicate that this European bison population has been exposed to BVD virus or BVD-like viruses and BoHV-2.

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“…A estratégia de latência viral do BoHV-1 faz do animal infectado um portador assintomático e potencial transmissor do vírus devido aos freqüentes episódios de reexcreção viral (ACKERMANN; PETERHANS; WYLER, 1982). Na infecção pelo BVDV uma pequena proporção (1% a 2%) dos animais nascidos pode ser constituída por animais persistentemente infectados (PI) e a presença de animais PI é a principal forma de transmissão e manutenção do vírus no rebanho (NETTLETON; ENTRICAN, 1995).…”

Section: Ibr Bvd E Leptospiroseunclassified

Falhas da reprodução na pecuária bovina de corte com ênfase para causas infecciosas

Junqueira

Alfieri

2006

Sem. Ci. Agr.

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ResumoNa pecuária bovina de corte especializada na cria de bezerros a eficiência da reprodução é um dos aspectos de maior destaque para o sucesso financeiro do investimento. Na presente revisão serão abordados os principais parâmetros utilizados para avaliar o desempenho reprodutivo de vacas de corte criadas extensivamente, bem como as principais causas infecciosas de falhas na reprodução que comprometem os custos da produção. Palavras-chave: Bovinos, reprodução, IBR, BVD, leptospirose AbstractThe reproductive efficiency in beef cattle breeding herds is one of the aspects of greater highlight for the financial success of the investment. In the present revision the main parameters used to evaluate the reproductive performance of cows in extensive management will be approached, as well as the more important infectious causes of the reproductive failures that affect the costs of the production.

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DNA of Bovine IPV-Virus (BHV-1, IPV Strain) in the Sacral Ganglia of Latently Infected Calves

Cited by 49 publications

References 0 publications

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum

Virologic Investigations of Free-Living European Bison (Bison Bonasus) From the Bialowieza Primeval Forest, Poland

Falhas da reprodução na pecuária bovina de corte com ênfase para causas infecciosas

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