DNA microsponge-templated growth of metal nanoparticles for signal-enhanced colorimetric detection

Ji, Yoonbin; Lee, Jong Bum

doi:10.1016/j.apsusc.2021.151028

Cited by 2 publications

(1 citation statement)

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“…Until recently, a variety of multiscale nucleic acid-based structures have been reported, holding promise for diverse applications. − To broaden the scope of nucleic acid scaffolds, we sought to explore three-dimensional DNA-based materials. We chose DNA nanoflowers (DNFs), − a well-studied theragnostic agent, because DNFs can be labeled with and can increase the local concentration of functional molecules. Thus, we aimed to investigate whether NuABDs could mediate polymerization when encapsulated locally within DNFs rather than when being homogeneously dispersed.…”

Section: Resultsmentioning

confidence: 99%

Nucleic Acid-Binding Dyes as Versatile Photocatalysts for Atom-Transfer Radical Polymerization

Jeong,

Hu,

Yin

et al. 2024

J. Am. Chem. Soc.

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Nucleic acid-binding dyes (NuABDs) are fluorogenic probes that light up after binding to nucleic acids. Taking advantage of their fluorogenicity, NuABDs have been widely utilized in the fields of nanotechnology and biotechnology for diagnostic and analytical applications. We demonstrate the potential of NuABDs together with an appropriate nucleic acid scaffold as an intriguing photocatalyst for precisely controlled atom-transfer radical polymerization (ATRP). Additionally, we systematically investigated the thermodynamic and electrochemical properties of the dyes, providing insights into the mechanism that drives the photopolymerization. The versatility of the NuABD-based platform was also demonstrated through successful polymerizations using several NuABDs in conjunction with diverse nucleic acid scaffolds, such as G-quadruplex DNA or DNA nanoflowers. This study not only extends the horizons of controlled photopolymerization but also broadens opportunities for nucleic acid-based materials and technologies, including nucleic acid−polymer biohybrids and stimuli-responsive ATRP platforms.

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