2017
DOI: 10.1016/j.ejca.2017.01.014
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Aim of the study A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as ‘epigenetic clock’, has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based biomarkers for risk stratification. Methods Here, we profiled DNA methylation changes in a nested case–contr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

4
142
3

Year Published

2017
2017
2023
2023

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 147 publications
(149 citation statements)
references
References 46 publications
4
142
3
Order By: Relevance
“…Weak evidence of increased cancer mortality risk was reported (based on 34 deaths: HR 5 1.05, 95% CI: 0.99-1.12), which is consistent with the findings of our study. A recent and larger-scale European study which included 480 breast cancer cases and matched controls 30 reported an increased risk associated with IEAA-Horvath (OR per one year 5 1.04, 95%CI: 1.01-1.08). The association appeared to be confined to postmenopausal women, but heterogeneity by menopausal status was not tested.…”
Section: Discussionmentioning
confidence: 99%
“…Weak evidence of increased cancer mortality risk was reported (based on 34 deaths: HR 5 1.05, 95% CI: 0.99-1.12), which is consistent with the findings of our study. A recent and larger-scale European study which included 480 breast cancer cases and matched controls 30 reported an increased risk associated with IEAA-Horvath (OR per one year 5 1.04, 95%CI: 1.01-1.08). The association appeared to be confined to postmenopausal women, but heterogeneity by menopausal status was not tested.…”
Section: Discussionmentioning
confidence: 99%
“…Physical activity may also reduce the impact of accelerated aging observed in cancer survivors . At the cellular level, dynamic, epigenetic DNA methylation profiles are associated with aging, cancer, physical activity, and cognition . It is important to note that age‐related DNA methylation is associated with age‐related gene transcription .…”
Section: Discussionmentioning
confidence: 99%
“…Specifically, numerous studies have been published documenting age-related DNA hypermethylation and acceleration of this process could be a biomarker of cancer risk (15-18). Data from an in vivo model demonstrated that age-related methylation changes in blood accelerate during the development of myelodysplastic syndromes and acute myeloid leukemia (AML) (15).…”
Section: Cancer Risk Assessmentmentioning
confidence: 99%
“…In a case-control study of breast cancer, peripheral blood DNA methylation was evaluated with respect to an age estimator; residuals in the model defined a measure of intrinsic epigenetic age acceleration (IEAA). A one unit increase in IEAA as determined by regression of epigenetic on chronological age, was reported to increase the risk of developing breast cancer by 4% (OR, 1.04; 95% CI, 1.007-1.0076) (17,18). Another recent study reported that the extent of age-related DNA hypermethylation varies by tissue and is correlated with site-specific lifetime cancer risk (15).…”
Section: Cancer Risk Assessmentmentioning
confidence: 99%