2021
DOI: 10.18632/aging.202544
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Abstract: Fetal perturbations in DNA methylation during lung development may reveal insights into the enduring impacts on adult lung health and disease during aging that have not been explored altogether before. We studied the association between genome-wide DNA-methylation and post-conception age in fetal-lung (n=78, 42 exposed to in-utero-smoke (IUS)) tissue and chronological age in adult-lung tissue (n=160, 114 with Chronic Obstructive Pulmonary Disease) using multi-variate linear regression models with co… Show more

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Cited by 6 publications
(2 citation statements)
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“…This clock site is in the promoter region and positively correlates with age, similarly to what we observed in both mouse and NMR (r = 0.463, p = 2.67E-06). In addition, a CpG site in the promoter region of human Mab21l2 (cg05878390 in the 450k array) was among the top 20 significant differentially methylated CpGs associated with age in a fetal lung dataset of in-utero-smoke and control samples at 57-122 days of gestation 50 . This gene was also differentially methylated in the dorsolateral prefrontal cortex of opioid users in humans, and there was a significant association between opioid use and the Levine phenotypic age 51 .…”
Section: Discussionmentioning
confidence: 99%
“…This clock site is in the promoter region and positively correlates with age, similarly to what we observed in both mouse and NMR (r = 0.463, p = 2.67E-06). In addition, a CpG site in the promoter region of human Mab21l2 (cg05878390 in the 450k array) was among the top 20 significant differentially methylated CpGs associated with age in a fetal lung dataset of in-utero-smoke and control samples at 57-122 days of gestation 50 . This gene was also differentially methylated in the dorsolateral prefrontal cortex of opioid users in humans, and there was a significant association between opioid use and the Levine phenotypic age 51 .…”
Section: Discussionmentioning
confidence: 99%
“…Alzheimer’s disease, cancer, cardiovascular disease, and diabetes are some of the more well-studied diseases associated with an aged epigenetic landscape [ 8 , 9 , 10 , 11 , 12 , 13 ]. Studies have even linked prognosis following cancer diagnosis with the extent of an aged epigenetic clock [ 14 ].…”
mentioning
confidence: 99%