Qiong Lin, Carola I. Weidner, Ivan G. Costa, Riccardo E. Marioni, Marcelo R. P. Ferreira, Ian J. Deary, Wolfgang Wagner
Abstract:DNA-methylation (DNAm) levels at age-associated CpG sites can be combined into epigenetic aging signatures to estimate donor age. It has been demonstrated that the difference between such epigenetic age-predictions and chronological age is indicative for of all-cause mortality in later life. In this study, we tested alternative epigenetic signatures and followed the hypothesis that even individual age-associated CpG sites might be indicative for life-expectancy. Using a 99-CpG aging model, a five-year higher a…
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