DNA methylation analysis in plants: review of computational tools and future perspectives

Abstract

Genome-wide DNA methylation studies have quickly expanded due to advances in next-generation sequencing techniques along with a wealth of computational tools to analyze the data. Most of our knowledge about DNA methylation profiles, epigenetic heritability and the function of DNA methylation in plants derives from the model species Arabidopsis thaliana. There are increasingly many studies on DNA methylation in plants—uncovering methylation profiles and explaining variations in different plant tissues. Addition…