DNA‐Guided Programmable Protein Assemblies for Biomedical Applications

Abstract

While the protein assemblies have been found widely existing and playing significant roles in biological systems, their imitation and re‐construction is further boosting more applications in biomedical research, such as enzymatic reaction regulation, sensing, and biomedicine. DNA nanotechnology provides a programmable strategy for the fabrication of nanostructures with unprecedented accuracy on the nanoscale. By linking the DNA nanotechnology with proteins of different functions, the precise construction of DNA‐guided protein assemblies can be achieved for various biomedical applications. This minireview summarizes the recent advances in the programmable protein assemblies on DNA nanoplatforms and discusses the outlook of DNA‐guided protein assemblies in the biomedical research.

Programmed Assembly of DNA Templates by Silver Nanowires

“…Moreover, the programmed assembly of DNA was used to construct arbitrary shapes and patterns which intern utilized as higher order template for hierarchical organization of metallized nanowires, nanoarrays and biomaterials. [23][24][25][26] Until now, it is not difficult to place homogenous materials on a single DNA nanostructure with sub-10 nm precision, given that site-specific modification on the DNA nano-breadboard can be achieved by sequencespecific self-assembly. [27][28][29] For example, Fan and coworkers reported the integration of single wall-carbon nanotube (SWCNT) on 2D DO with absolute precision by modifying the ends of SWCNT with complementary oligonucleotide strands.…”