Abstract:Purpose
This study aims to determine to what extent sperm DNA damage is associated with semen quality and assisted reproduction technology (ART) treatment outcomes.
Methods
105 male partners of couples attending for infertility treatment were recruited and DNA integrity was measured by a neutral Comet assay and N7-methyldeoxyguanosine (N7-MedG) DNA levels by an immunoslotblot in sperm prepared by density gradient centrifugation for treatment use. Associations between measures of DNA damage (%tail DNA, propor… Show more
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