2004
DOI: 10.1007/s00280-004-0877-z View full text |Buy / Rent full text
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Abstract: Salvicine, a diterpenoid quinone compound, possesses potent in vitro and in vivo antitumor activity. Salvicine is a novel non-intercalative topoisomerase II poison. In this study salvicine induced evident DNA damage, which was further characterized as double-strand breaks mainly in MCF-7 human breast cancer cells. The degree of damage was highly correlated with growth inhibition of MCF-7. Using a PCR-stop assay we demonstrated that this damage was selective. Preferential damage occurred in the p2 promoter regi… Show more

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“…The cytotoxicity of salvicine against MCF-7 cells was evaluated by sulforhodamine B (SRB) dye assay, as described previously (Lu et al, 2005). In brief, 100 l of cells (5 ϫ 10 4 /ml) per well were seeded in 96-well plates.…”
Section: Methodsmentioning
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“…The cytotoxicity of salvicine against MCF-7 cells was evaluated by sulforhodamine B (SRB) dye assay, as described previously (Lu et al, 2005). In brief, 100 l of cells (5 ϫ 10 4 /ml) per well were seeded in 96-well plates.…”
Section: Methodsmentioning
“…DNA DSBs were evaluated using the neutral single-cell gel electrophoresis assay (the neutral comet assay), as described previously (Olive et al, 1990) with minor modifications (Lu et al, 2005). In brief, MCF-7 cells (5 ϫ 10 5 /ml) were seeded into six-well plates, incubated overnight, and then treated with various concentrations of salvicine for the indicated times.…”
Section: Methodsmentioning
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“…DNA DSBs were evaluated using the neutral single-cell gel electrophoresis (neutral comet assays) as described previously (Olive et al, 1990) with minor modifications (Lu et al, 2005a). Quantification was performed by analyzing at least 50 randomly selected comets per slide with the Komet 5.5 software (Kinetic Imaging Ltd., Nottingham, UK).…”
Section: Methodsmentioning