Biochemical Pharmacology volume 76, issue 8, P987-996 2008 DOI: 10.1016/j.bcp.2008.08.010 View full text
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Zhengguan Yang, Alan S. Waldman, Michael D. Wyatt

Abstract: AbstractDNA damage is accepted as a consequence of thymidylate deprivation induced by chemotherapeutic inhibitors of thymidylate synthase (TS), but the types of damage and signaling responses remain incompletely understood. Thymidylate deprivation increases dUTP and uracil in DNA, which is removed by Base Excision Repair (BER). Because BER requires a synthesis step, strand break intermediates presumably accumulate. Thymidylate deprivation also induces cell cycle arrest during replication. Homologous recombina…

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