DNA‐Catalyzed Formation of Nucleopeptide Linkages

Pradeepkumar, P. I.; Höbartner, Claudia; Baum, Dana A.; Silverman, Scott

doi:10.1002/anie.200703676

Cited by 86 publications

(71 citation statements)

References 51 publications

(31 reference statements)

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“…Some of this work was recently reviewed [22]; selected highlights are provided here (Figure 3B). Deoxyribozymes have been found for conjugation of oligonucleotides to tyrosine [68–70], tyrosine phosphorylation [71,72], phosphotyrosine (pTyr) and phosphoserine (pSer) dephosphorylation [73], formation of dehydroalanine (Dha) by elimination of phosphate from pSer [74], and lysine modification [75]. The case of tyrosine phosphorylation illustrates that DNA catalysts can distinguish among various peptide substrate sequences [72], which is important for sequence-specific modification.…”

Section: Reaction Scope Of Catalysis By Dnamentioning

confidence: 99%

See 1 more Smart Citation

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

Silverman

2016

Trends in Biochemical Sciences

297

215

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The discovery of natural RNA enzymes (ribozymes) prompted the pursuit of artificial DNA enzymes (deoxyribozymes) by in vitro selection methods. A key motivation is the conceptual and practical advantages of DNA relative to proteins and RNA. Early studies focused on RNA-cleaving deoxyribozymes, and more recent experiments have expanded the breadth of catalytic DNA to many other reactions. Including modified nucleotides has the potential to widen the scope of DNA enzymes even further. Practical applications of deoxyribozymes include their use as sensors for metal ions and small molecules. Structural studies of deoxyribozymes are just beginning; mechanistic experiments will surely follow. From the first report 21 years ago, the field of deoxyribozymes has promise for both fundamental and applied advances in chemistry, biology, and other disciplines.

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Section: Reaction Scope Of Catalysis By Dnamentioning

confidence: 99%

“…(B) Examples of DNA-catalyzed peptide side chain and backbone modification [22,68–74]. (C) Capture step during in vitro selection for identification of deoxyribozymes that form dehydroalanine (Dha) from phosphoserine (pSer) [74].…”

Section: Figurementioning

confidence: 99%

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

Silverman

2016

Trends in Biochemical Sciences

297

215

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“…386 The same design has been used such that in place of (ribo)adenosine a tyrosine has been incorporated into the DNA oligonucleotides backbone which can then conjugate onto the adjacent oligonucleotides, in this case the latter bears a 5 0 -triphosphate. 387 A two-tiered G-quadruplex DNAzyme linked to a duplex region will undergo self-phosphorylation with ATP or GTP adding a 5 0 -phosphate to the DNAzyme. 388 Previously a Diels-Alder RNAzyme was evolved by in vitro selection in which the ribozyme was conjugated to anthracene and underwent a Diels-Alder reaction with a maleimide.…”

Section: Aptamers and (Deoxy)ribozymesmentioning

confidence: 99%

Nucleotides and Nucleic Acids; Oligo- and Polynucleotides

Loakes

2010

Organophosphorus Chemistry

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“…[154] As a unnatural nucleic acids containing peptides, peptide nucleic acids (PNA) already have found successful applications in biology and biomedicine, such as serving as an analog of DNA. [155] Therefore, it is quite natural to integrate nucleobases with small peptides for generating supramolecular hydrogelators based on nucleopeptides. Here, besides some studies of nucleosides based peptides, [153, 156] we will introduce some works to use nucleopeptides to serve as building blocks for developing novel class of supramolecular hydrogels.…”

Section: Supramolecular Hydrogels Made Of the Hybrids Of Basic Biomentioning

confidence: 99%

Supramolecular Hydrogels Made of Basic Biological Building Blocks

Zhou

2014

Chemistry An Asian Journal

110

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As a consequence of the self-assembly of small organic molecules in water, supramolecular hydrogels are evolving from serendipitous events during organic synthesis to become a new type of materials that promise increased applications in biomedicine. In this focus review, we describe the recent development on the use of basic biological building blocks for creating molecules that act as hydrogelators and the potential applications of the corresponding hydrogels. After introducing the concept of supramolecular hydrogels and defining the scope of this review, we briefly describe the methods for making and characterizing supramolecular hydrogels. Then, we discuss representative hydrogelators according to the categories of their building blocks, such as amino acids, nucleobases, and saccharides, and highlight the applications of the hydrogels when necessary. Finally, we offer our perspectives and outlooks on this fast-growing field at the interface of organic chemistry, materials, biology, and medicine. By providing a snapshot for chemists, engineers, and medical scientists, we hope that this focus review will contribute to the development of multidisciplinary research on supramolecular hydrogels for a wide range of applications in different fields.

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DNA‐Catalyzed Formation of Nucleopeptide Linkages

Cited by 86 publications

References 51 publications

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

Nucleotides and Nucleic Acids; Oligo- and Polynucleotides

Supramolecular Hydrogels Made of Basic Biological Building Blocks

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