DNA binding activity of novel discotic phenathridine derivative

Ambipolar Charge Transport Properties of Naphthophenanthridine Discotic Liquid Crystals

“…Thermotropic discotic liquid crystalline materials overcome this restriction through columnar organization, that is, the disc-shaped molecules stack on top of each other to form a one-dimensional column which further occupies various two-dimensional lattices. These mesogenic materials, which are known as one of the delicate phases of matter, exhibit both order and mobility, and the homogeneous domains can be achieved sometimes to a larger length scale which is essentially required for semiconducting devices. − The discovery of discotic liquid crystals by Chandrasekhar et al has motivated research groups around the globe to explore new discogens and study their charge transport character. − Discotic liquid crystals have been used in photoconductive devices due to their high charge carrier mobility. , Generally, the mesogenic stability of discotics and the charge transport property are influenced by the size of the π-conjugated core, the nature of substituents, and the relative positioning of the neighboring molecules. − Recently, nitrogen-containing polycyclic aromatic molecules have drawn enormous interest as n-type semiconductors because of their expanded electron affinity and enhanced π-stacking. − Many reports on nitrogen-fused discotic systems are known to be highly emissive for a broad wavelength range , and device applications. − Our group has previously reported various nitrogen-incorporated discotic systems through ring fusion and ring annulation for their liquid crystallinity and applications. − The charge transport properties of many different discotic derivatives and their nanocomposites have been reported in the literature. − The ambipolar charge transporting molecules are of special interest for organic semiconductors as they enable the fabrication of complementary circuits, OFETs, and OLEDs. − In addition, fine-tuning the energy levels of the HOMO and the LUMO by incorporating substituents may result in desirable charge transport properties . Generally, this type of bipolar transport has been achieved through bulk heterojunctions of donor and acceptor materials as active components , or by introducing different source and drain electrodes to facilitate the charge transport .…”

Design and Synthesis of Carbothioamide/Carboxamide-Based Pyrazoline Analogs as Potential Anticancer Agents: Apoptosis, Molecular Docking, ADME Assay, and DNA Binding Studies

“…Titration experiments were repeated three times ( n = 3) to ensure consistent results. The binding affinity ( K b ) was calculated using eq : − where A obsd /[compound], the extinction coefficient of the complex in the bound form, and the extinction coefficient for the complex are represented by absorption coefficients, ε a , ε b , and ε f , respectively.…”

Synthesis and anticancer activities of novel Pt (II) and Pd (II) complexes with 4‐(2,2′:6′,2″‐terpyridin‐4′‐yl)phenol as ligand

“…Because the coupling π orbitals are partially filled with electrons, the interaction between the complex and DNA through intercalation leads to a larger hypochromic effect, along with or without a small red shift in the wavelength. The degree of the hypochromic effect is determined by the capacity of the complex to bind to DNA, which in turn is determined by the strength of the stacking contact between aromatic groups and DNA base pairs 53,54 …”