DNA amplification and expression of FADD in oral squamous cell carcinoma

Prapinjumrune, Chanwit; Morita, Keiichi; Kuribayashi, Yuri; Hanabata, Yasuko; Shi, Qi; Nakajima, Yusuke; Inazawa, Johji; Omura, Ken

doi:10.1111/j.1600-0714.2009.00847.x

Cited by 23 publications

(34 citation statements)

References 19 publications

(22 reference statements)

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“…This concept was supported by the fact that FADD is deficient in certain types of cancer (11,12). However, multiple studies have revealed that FADD is overexpressed in many other forms of cancer (14)(15)(16)(17). Consistent with previous observations, the present study indicated that FADD is overexpressed in pancreatic cancer cells.…”

Section: Discussionsupporting

confidence: 81%

“…FADD is located on chromosome 11q13, a region that is frequently amplified in several types of cancer, including lung, head and neck squamous cell carcinoma, laryngeal and pharyngeal carcinomas, and breast and ovarian carcinomas (13). FADD mRNA and protein levels are known to be increased in these forms of cancer (14)(15)(16)(17)(18). However, the role of FADD in these diseases remains to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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The role of FADD in pancreatic cancer cell proliferation and drug resistance

et al. 2017

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Abstract. Pancreatic cancer has one of the poorest patient outcomes and is highly resistant to chemotherapy. Identifying the molecular mechanisms involved in drug resistance is critical in the development of novel strategies to treat pancreatic cancer. The results of the present study demonstrate that Fas-associated death domain protein (FADD), a classical adaptor protein mediating apoptotic stimuli-induced cell death, protects pancreatic cancer cells from drug-induced apoptosis. In contrast to its classical apoptotic roles, it was observed that FADD is required for pancreatic cancer cell proliferation and that it is overexpressed to varying degrees in various types of pancreatic cancer cell. This leads to differing levels of drug resistance in pancreatic cancer cells, where drug resistance is positively correlated with FADD expression. Notably, the results of the present study demonstrate that FADD protects pancreatic cancer cells from drug-induced apoptosis, while RNA interference of FADD sensitizes drug-resistant cells to Adriamycin ® -mediated apoptosis. The results of the present study reveal unexpected roles for FADD in pancreatic cancer cell proliferation and drug resistance.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

The role of FADD in pancreatic cancer cell proliferation and drug resistance

et al. 2017

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“…According to the previous reports, high expression of FADD was associated with factors indicating poor prognosis in squamous cell carcinoma of the head and neck [14,27] and oral squamous cell carcinoma [28]. However, contradictory clinical associations of FADD expression were also reported.…”

Section: Discussionmentioning

confidence: 99%

“…FADD is an adaptor molecule interacting with many kinds of death receptors and induces apoptosis by caspase-8 [12,13]. FADD expression was associated with metastasis in squamous cell carcinoma of the head and neck [14] and poor prognosis in oral squamous cell carcinoma [15] and lung adenocarcinoma [16]. Because the amplification of FADD does not confined in a single gene, TMEM16A or PPFIA1 , which are in close proximity to FADD , may be amplified concomitantly.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast

et al. 2014

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Background11q13 region is a frequently amplified locus in human malignancies. Among the genes located in this region, FADD is one of the alleged driving genes. Because amplification is not generally confined to a single gene and amplified genes may not show increased expression, we need to evaluate clinical significance of changes occurring in 11q13 region to understand their roles in carcinogenesis. Therefore, we screened expressions of FADD and closely located genes (PPFIA1 and TMEM16A) and evaluated the expressions to find clinical significance in invasive ductal carcinoma of the breast.MethodsNinety-eight cases of invasive ductal carcinoma of the breast were collected. Using archival tissues resected from the cases, we built a tissue microarray and used it in immunohistochemistry. We evaluated the association of FADD, PPFIA1, and TMEM16A expression scores with clinicopathological parameters, including disease-free survival.ResultsFADD expression was associated with T stage (P = 0.046). The combined score of FADD, PPFIA1, and TMEM16A gene expressions was associated with perineural invasion (P = 0.022). Although individual gene expressions of TMEM16A, FADD, and PPFIA1 failed to show significant association with disease-free survival, combined gene expression scores did show association with disease-free survival (P = 0.034).ConclusionsFADD, TMEM16A, and PPFIA1 gene expressions as a whole were associated with disease-free survival in breast cancer.

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“…6,7 This elevation is likely due to increased DNA amplification. 7,8 Moreover, positive FADD expression is significantly associated with LNM of oral (e.g., tongue) squamous cell carcinoma and worse survival. 7,8 (Tu -met ), primary tumors from patients with LNM (Tu +met ) and the matching LNM.…”

Section: Introductionmentioning

confidence: 99%