Diverticular Disease: a Gut Microbiota Perspective

Ticinesi, Andrea; Nouvenne, Antonio; Corrente, V.; Tana, Claudio; Mario, F. Di; Meschi, Tiziana

doi:10.15403/jgld-277

Cited by 33 publications

(25 citation statements)

References 106 publications

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“…Non-CRC controls from Chile and India were asymptomatic individuals working in the affiliated Universities. Non-CRC controls from Vietnam and Argentina underwent colonoscopy, yielding descriptions of ‘macroscopically normal bowel’ ( n = 14), diverticulosis ( n = 4), or ‘macroscopically normal bowel with haemorrhoids’ ( n = 2), which are grouped together in subsequent analyses as non-CRC control (it should be noted that these are common colonoscopy findings in older populations and have not been associated with a distinct microbiome profile) [ 49 ] . The total reads/sample (CRC patients, non-CRC controls and UK volunteers) were 51,000–167,000 (median 117,000).…”

Section: Resultsmentioning

confidence: 99%

The colorectal cancer-associated faecal microbiome of developing countries resembles that of developed countries

et al. 2021

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Background The incidence of colorectal cancer (CRC) is increasing in developing countries, yet limited research on the CRC- associated microbiota has been conducted in these areas, in part due to scarce resources, facilities, and the difficulty of fresh or frozen stool storage/transport. Here, we aimed (1) to establish a broad representation of diverse developing countries (Argentina, Chile, India, and Vietnam); (2) to validate a ‘resource-light’ sample-collection protocol translatable in these settings using guaiac faecal occult blood test (gFOBT) cards stored and, importantly, shipped internationally at room temperature; (3) to perform initial profiling of the collective CRC-associated microbiome of these developing countries; and (4) to compare this quantitatively with established CRC biomarkers from developed countries. Methods We assessed the effect of international storage and transport at room temperature by replicating gFOBT from five UK volunteers, storing two in the UK, and sending replicates to institutes in the four countries. Next, to determine the effect of prolonged UK storage, DNA extraction replicates for a subset of samples were performed up to 252 days apart. To profile the CRC-associated microbiome of developing countries, gFOBT were collected from 41 treatment-naïve CRC patients and 40 non-CRC controls from across the four institutes, and V4 16S rRNA gene sequencing was performed. Finally, we constructed a random forest (RF) model that was trained and tested against existing datasets from developed countries. Results The microbiome was stably assayed when samples were stored/transported at room temperature and after prolonged UK storage. Large-scale microbiome structure was separated by country and continent, with a smaller effect from CRC. Importantly, the RF model performed similarly to models trained using external datasets and identified similar taxa of importance (Parvimonas, Peptostreptococcus, Fusobacterium, Alistipes, and Escherichia). Conclusions This study demonstrates that gFOBT, stored and transported at room temperature, represents a suitable method of faecal sample collection for amplicon-based microbiome biomarkers in developing countries and suggests a CRC-faecal microbiome association that is consistent between developed and developing countries.

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Section: Resultsmentioning

confidence: 99%

The colorectal cancer-associated faecal microbiome of developing countries resembles that of developed countries

et al. 2021

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“…The concept of the "gut-brain axis," suggesting a functional association between the gut and the brain, has firstly been proclaimed in 1980 [17] and has gained increasing attention since. Gastrointestinal inflammation, as observed during acute and chronic diverticulitis, is often associated with microbial dysbiosis and leads to an impaired intestinal barrier function [18]. This condition results in a translocation of proinflammatory cytokines (e.g., TNF-a, IL-6), lipopolysaccharides (LPS) and microbial metabolites (e.g., short-chain fatty acids), which in turn crucially influence central neurotransmitter levels, the hypothalamic-pituitary-adrenal axis, and the brain barrier integrity.…”

Section: Discussionmentioning

confidence: 99%

Diverticular disease is associated with an increased incidence rate of depression and anxiety disorders

Loosen

Paffenholz

Luedde

et al. 2021

Int J Colorectal Dis

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Background Diverticular disease represents a gastrointestinal disorder of high prevalence in developed countries that often leads to psychological distress. Here, we aimed at evaluating a potential association between diverticular disease and depression or anxiety disorders in outpatients in Germany. Methods Using the Disease Analyzer database featuring data of over 8 million patients treated in German general practices, we identified 61.556 patients with diverticular disease (ICD-10: K57) who were 1:1 matched by age, sex, index year, and the Charlson Comorbidity Index to 61.556 patients without diverticular disease. The association between diverticular disease and depression or anxiety disorders was evaluated in Cox regression models. Results Within 5 years after the initial diagnosis of diverticular disease, 14.0% of patients with and 10.6% of individuals without diverticular disease were diagnosed with depression (HR 1.34, 95%CI 1.29–1.39, p < 0.001). Similarly, the incidence of anxiety disorder was significantly higher in patients with diverticular disease (HR 1.55, 95%CI 1.46–1.64, p < 0.001). Finally, the prescription rate for antidepressant drugs was significantly higher in diverticular disease patients compared to individuals without diverticular disease (9.4% vs. 6.1%, HR 1.56, 95%CI 1.49–1.62, p < 0.001). These associations were confirmed for different age groups and both sexes. Conclusion Our data provide evidence that diverticular disease is associated with an increased incidence of depression and anxiety disorders. Despite that fact that confounding factors such as deprivation and patient personality have to be taken into account, we suggest that patients with diverticular disease are regularly screened for symptoms of depression and anxiety disorders.

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“…Profiling studies of the microbiota in CD have highlighted that the overgrowth of the phylum Firmicutes (Ruminococcus, Pseudobutyrivibrio, and Christensenellaceae family) may be associated not only with SUDD, but also with AD occurrence [40,41]. Indeed, diverticular pockets may represent unique niches that selectively promote the development of specific microbes, leading to inflammation and clinical manifestations of CD.…”

Section: Gut Microbiota: a Possible Key Link Between Nafld And Colonic Diverticulosis?mentioning

confidence: 99%

The Interrelationship Among Non-Alcoholic Fatty Liver Disease, Colonic Diverticulosis and Metabolic Syndrome

Milovanović

Pantic

Dragašević

et al. 2021

JGLD

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Non-alcoholic fatty liver disease and colonic diverticulosis are widespread, obesity-related diseases. It hasrecently become clear that non-alcoholic fatty liver disease is a systemic disease and may play a key rolein metabolic syndrome; therefore, the term metabolic-dysfunction-associated fatty liver disease has beenintroduced in the literature. Excess visceral adipose tissue is an important predictor of complications in bothnon-alcoholic fatty liver disease and colonic diverticulosis. Current evidence suggests that intestinal dysbiosismay be involved in the development of both non-alcoholic fatty liver disease and colonic diverticulosis, andthat metabolic syndrome is a consequence rather than a cause of this complex relationship. In this review, ouraim was to assess the current knowledge of the complex interplay between metabolic syndrome, non-alcoholicfatty liver disease, and colonic diverticulosis.

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Diverticular Disease: a Gut Microbiota Perspective

Cited by 33 publications

References 106 publications

The colorectal cancer-associated faecal microbiome of developing countries resembles that of developed countries

The colorectal cancer-associated faecal microbiome of developing countries resembles that of developed countries

Diverticular disease is associated with an increased incidence rate of depression and anxiety disorders

The Interrelationship Among Non-Alcoholic Fatty Liver Disease, Colonic Diverticulosis and Metabolic Syndrome

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