Diversity of Heterotrophic Halophilic Bacteria Isolated from Coastal Solar Salterns, Bulgaria and Their Ability to Synthesize Bioactive Molecules with Biotechnological Impact

Boyadzhieva, Ivanka; Tomova, Iva; Radchenkova, Nadja; Kambourova, Margarita; Poli, Annarita; Vasileva−Tonkova, Evgenia

doi:10.1134/s0026261718040033

Cited by 10 publications

(6 citation statements)

References 35 publications

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“…Halomonas was isolated from the two salterns (Boyadzhieva et al 2018). Other genera Salimicrobium, Halalkalibacillus, Virgibacillus, Alkalibacillus, Marinococcus, Halobacillus, Halomonas, Idiomarina, Chromohalobacter, and Halovibrio were obtained from a hypersaline pond in Sichuan, China (Tang et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…To assess the effects of hypersaline environment on microbial composition, many microbial biogeography studies examined coastal soils and sediments present in saltern fields. The phyla Proteobacteria, Firmicutes, and Actinobacteria were isolated from coastal solar salterns and revealed they have the ability to synthesize bioactive molecules (Boyadzhieva et al 2018). Tang et al (2011) reported 47 bacterial isolates either in the phylum Firmicutes or in the class Gammaproteobacteria isolated from a hypersaline pond in Sichuan, China.…”

Section: Introductionmentioning

confidence: 99%

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Salt-tolerance Function in Halotolerant Bacteria from Coastal Soil and Sediment Present near Saltern Field of Hainan Island, China

Yong-gan¹,

Zhang²,

Luo³

et al. 2021

Preprint

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Characterization of the salt-tolerance function in microbial communities is important for understanding the soil and sediment biodiversity distribution near saltern affected by the environmental factors. Here, we combined high-throughput sequencing of 16S rDNA and ITS to investigate the distribution and salt-tolerance function of microbial communities in coastal soils and sediments present near Yinggehai saltern field of Hainan Island, China. The microbial communities in the soil and sediments of the land zone (YGHLS), the intertidal zone (YGHIS), and inshore zone (YGHWS) were compared. PCoA of weighted and unweighted UniFrac distances showed the difference in soil microbial communities across the samples. ANOSIM analysis revealed that the three samples were separated from each other. Halomonas , Halobacillus and Wallemia presented in the samples and accounted for 0.0335 ± 0.0586%, 0.0241 ± 0.0304% and 0.0308 ± 0.0445% of the total microbial community. Relative abundance of Na + :H + antiporter, Trk system potassium uptake protein and Kdp operon response regulator in the samples exceed 0.02%, 0.09% and 0.06% respectively. It revealed that the halotolerant bacteria of Yinggehai coastal soil and sediment mainly take the Trk system for salt-tolerance function.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salt-tolerance Function in Halotolerant Bacteria from Coastal Soil and Sediment Present near Saltern Field of Hainan Island, China

Yong-gan¹,

Zhang²,

Luo³

et al. 2021

Preprint

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“…Gamma Proteobacteria from coastal solar salterns, such as Halomonas smyrnensis and Halomonas variabilis, were found to have antibacterial properties against S. pasteuri and E. coli. Salinicoccus roseus and Virgibacillus salaries exhibited activity against M. luteus, A. johnsonii, X. oryzae, C. lipolytica, S. cerevisiae, and M. luteus, X. oryzae, C. lipolytica, S. cerevisiae [89]. The cell supernatants of Nocardioides sp.…”

Section: Other Halophilic Bacterial Speciesmentioning

confidence: 99%

“…E37 also exhibited a wide antimicrobial activity with 250, 62.5, 125, and 500 µg/mL MICs, respectively, against the same pathogens mentioned above. Generally, EPS produced from halophilic isolates displayed more antibacterial action from the genera Halomonas, Chromohalobacter, Salinivibrio, Nesiotobacter, Brevibacterium, Virgibacillus, and Salinicoccus against E. coli, S. pasteuri, B. cereus, P. aeruginosa, M. luteus, and S. cerevisiae [89]. According to the literature, a large number ofEPS were produced in saline areas, but only moderate antibacterial activity against microbial pathogens was identified.…”

Section: Exopolysaccharidesmentioning

confidence: 99%

Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens

et al. 2022

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Microbial pathogens that cause severe infections and are resistant to drugs are simultaneously becoming more active. This urgently calls for novel effective antibiotics. Organisms from extreme environments are known to synthesize novel bioprospecting molecules for biomedical applications due to their peculiar characteristics of growth and physiological conditions. Antimicrobial developments from hypersaline environments, such as lagoons, estuaries, and salterns, accommodate several halophilic microbes. Salinity is a distinctive environmental factor that continuously promotes the metabolic adaptation and flexibility of halophilic microbes for their survival at minimum nutritional requirements. A genetic adaptation to extreme solar radiation, ionic strength, and desiccation makes them promising candidates for drug discovery. More microbiota identified via sequencing and ‘omics’ approaches signify the hypersaline environments where compounds are produced. Microbial genera such as Bacillus, Actinobacteria, Halorubrum and Aspergillus are producing a substantial number of antimicrobial compounds. Several strategies were applied for producing novel antimicrobials from halophiles including a consortia approach. Promising results indicate that halophilic microbes can be utilised as prolific sources of bioactive metabolites with pharmaceutical potentialto expand natural product research towards diverse phylogenetic microbial groups which inhabit salterns. The present study reviews interesting antimicrobial compounds retrieved from microbial sources of various saltern environments, with a discussion of their potency in providing novel drugs against clinically drug-resistant microbes.

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“…Members of the domain Bacteria belonged to genera Salicola, Pontibacillus, Halomonas, Marinococcus, and Halobacillus, whereas the only member of domain Archaea isolated belonged to the genus Halorubrum 45 . Boyadzhieva isolated 20 morphologically different moderately halophilic and two halotolerant strains affiliated with 11 species from eight genera referred to the phyla Proteobacteria, Firmicutes, and Actinobacteria 46 . Gram-negative bacteria belonged to the genera Halomonas, Chromohalobacter, Salinivibrio, Cobetia, and Nesiotobacter, and gram-positive strains were representatives of the genera Virgibacillus, Salinicoccus, and Brevibacterium.…”

Section: Quick Response Codementioning

confidence: 99%

Untitled

2021

IJPSR

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Microorganisms that live their life in places with high salt concentrations are known as Halophiles. Halophilic bacteria play a majority role in hypersaline environments than other microorganisms. These Halophiles are having intense strategies of adaptation and tolerate them to sustain their survival in the saline extreme, such adaptation in hypersaline environments makes them to give unique attention to the researcher for their biological properties. The diversity of halophiles bacteria incorporates aerobic and anaerobic phototrophs, aerobic heterotrophs, fermenters, denitrifies, sulfate reducers, and methanogens. The biotechnological important of the halophilic bacteria, such as producing a Novel bioactive compounds, industrially important enzyme, Bio-surfactants, Stabilizers Exopolysacharides, Probiotics etc. Secondary metabolites are organic compounds produced by bacteria, fungi, or plants which are not directly involved in the normal growth, development, or reproduction of the organism. Some common examples of secondary metabolites include ergot alkaloids, antibiotics, naphthalenes, nucleosides, phenazines, quinolines, terpenoids, peptides, and growth factors.

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Diversity of Heterotrophic Halophilic Bacteria Isolated from Coastal Solar Salterns, Bulgaria and Their Ability to Synthesize Bioactive Molecules with Biotechnological Impact

Cited by 10 publications

References 35 publications

Salt-tolerance Function in Halotolerant Bacteria from Coastal Soil and Sediment Present near Saltern Field of Hainan Island, China

Salt-tolerance Function in Halotolerant Bacteria from Coastal Soil and Sediment Present near Saltern Field of Hainan Island, China

Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens

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