Diversity and evolution of TIR-domain-containing proteins in bivalves and Metazoa: New insights from comparative genomics

Gerdol, Marco; Venier, Paola; Edomi, Paolo; Pallavicini, Alberto

doi:10.1016/j.dci.2017.01.014

Cited by 45 publications

(58 citation statements)

References 108 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TIR domain is found in a number of proteins linked to the detection of foreign ligands and to the ransduction of immune signals inside the cell. In detail, the expression of the cytosolic gene products MyD88, STING and ecTIR-DC families 6, 11 and 13 was particularly elevated in this tissue [89]. Moreover, a number of LITAF-like transcription factors, which may positively regulate the production of pro-inflammatory cytokines [90], were also selectively expressed in the gills.…”

Section: Resultsmentioning

confidence: 99%

The purplish bifurcate mussel Mytilisepta virgata gene expression atlas reveals a remarkable tissue functional specialization

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background Mytilisepta virgata is a marine mussel commonly found along the coasts of Japan. Although this species has been the subject of occasional studies concerning its ecological role, growth and reproduction, it has been so far almost completely neglected from a genetic and molecular point of view. In the present study we present a high quality de novo assembled transcriptome of the Japanese purplish mussel, which represents the first publicly available collection of expressed sequences for this species.ResultsThe assembled transcriptome comprises almost 50,000 contigs, with a N50 statistics of ~1 kilobase and a high estimated completeness based on the rate of BUSCOs identified, standing as one of the most exhaustive sequence resources available for mytiloid bivalves to date. Overall this data, accompanied by gene expression profiles from gills, digestive gland, mantle rim, foot and posterior adductor muscle, presents an accurate snapshot of the great functional specialization of these five tissues in adult mussels.ConclusionsWe highlight that one of the most striking features of the M. virgata transcriptome is the high abundance and diversification of lectin-like transcripts, which pertain to different gene families and appear to be expressed in particular in the digestive gland and in the gills. Therefore, these two tissues might be selected as preferential targets for the isolation of molecules with interesting carbohydrate-binding properties.In addition, by molecular phylogenomics, we provide solid evidence in support of the classification of M. virgata within the Brachidontinae subfamily. This result is in agreement with the previously proposed hypothesis that the morphological features traditionally used to group Mytilisepta spp. and Septifer spp. within the same clade are inappropriate due to homoplasy.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-017-4012-z) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultsmentioning

confidence: 99%

The purplish bifurcate mussel Mytilisepta virgata gene expression atlas reveals a remarkable tissue functional specialization

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some of these receptors are intracellular, e.g. the plant TNL and many invertebrate intracellular TIR domain‐containing proteins . In addition, some TIR‐containing proteins are used as adapters in the signaling pathway of the TIR receptors (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The IL‐1R‐like proteins in invertebrates, characterized by 2 Ig‐like domains, have scarce sequence homology with the vertebrate IL‐1R. As structurally conserved IL‐1 cytokines have not been unequivocally identified in invertebrates, the Ig/TIR domain combination of invertebrates has probably evolved independently, as it seems to have happened repeatedly in metazoan evolution . The putative absence of IL‐1 homologs in invertebrates suggests that Ig/TIR domain combination might have evolved in invertebrates for expanding their recognition and defensive capacity, exploiting the capacity of somatic recombination of Ig domains to generate a large number of molecules with distinct recognition specificity .…”

Section: Discussionmentioning

confidence: 99%

“…MyD88). The IL-1R family is a relatively recent addition to the TIR family, with IL-1R-like molecules described in some invertebrates, [436][437][438][439][440][441] and in all vertebrates. [442][443][444][445][446][447][448][449][450][451] The IL-1R-like proteins in invertebrates, characterized by 2 Ig-like domains, have scarce sequence homology with the vertebrate IL-1R.…”

Section: Evolution Of Il-1rmentioning

confidence: 99%

See 1 more Smart Citation

The family of the interleukin‐1 receptors

Boraschi

Italiani

Weil

et al. 2017

Immunological Reviews

264

225

View full text Add to dashboard Cite

The extracellular forms of the IL-1 cytokines are active through binding to specific receptors on the surface of target cells. IL-1 ligands bind to the extracellular portion of their ligand-binding receptor chain. For signaling to take place, a non-binding accessory chain is recruited into a heterotrimeric complex. The intracellular approximation of the Toll-IL-1-receptor (TIR) domains of the 2 receptor chains is the event that initiates signaling. The family of IL-1 receptors (IL-1R) includes 10 structurally related members, and the distantly related soluble protein IL-18BP that acts as inhibitor of the cytokine IL-18. Over the years the receptors of the IL-1 family have been known with many different names, with significant confusion. Thus, we will use here a recently proposed unifying nomenclature. The family includes several ligand-binding chains (IL-1R1, IL-1R2, IL-1R4, IL-1R5, and IL-1R6), 2 types of accessory chains (IL-1R3, IL-1R7), molecules that act as inhibitors of signaling (IL-1R2, IL-1R8, IL-18BP), and 2 orphan receptors (IL-1R9, IL-1R10). In this review, we will examine how the receptors of the IL-1 family regulate the inflammatory and anti-inflammatory functions of the IL-1 cytokines and are, more at large, involved in modulating defensive and pathological innate immunity and inflammation. Regulation of the IL-1/IL-1R system in the brain will be also described, as an example of the peculiarities of organ-specific modulation of inflammation.

show abstract

“…Just as the dual function of MyD88 signaling in intestine, MyD88 signaling in IECs promotes expression of selective antimicrobial peptide, which associate enhanced host resistance and survival, but after infection with the H hepaticus, innate cell-derived MyD88 signaling promote inflammatory gene expression leading to colitis and extra-intestinal inflammation. In nature, the binding surfaces or interfaces of TIR domain are highly conserved (Gerdol et al, 2017). That is, different proteins containing TIR domain in TLR signaling world use the similar interfaces to interact with their partners.…”

mentioning

confidence: 99%

Focalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old Diseases

Su¹,

Zhou²

2017

American Journal of Immunology

View full text Add to dashboard Cite

Diversity and evolution of TIR-domain-containing proteins in bivalves and Metazoa: New insights from comparative genomics

Cited by 45 publications

References 108 publications

The purplish bifurcate mussel Mytilisepta virgata gene expression atlas reveals a remarkable tissue functional specialization

The purplish bifurcate mussel Mytilisepta virgata gene expression atlas reveals a remarkable tissue functional specialization

The family of the interleukin‐1 receptors

Focalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old Diseases

Contact Info

Product

Resources

About