Divergent changes in PBN excitability in a mouse model of neuropathic pain
María L Torruella-Suárez,
Benjamin Neugebauer,
Krystal Flores-Felix
et al.
Abstract:The transition from acute to chronic pain involves maladaptive plasticity in central nociceptive pathways. Growing evidence suggests that changes within the parabrachial nucleus (PBN), an important component of the spino-parabrachio-amygdaloid pain pathway, are key contributors to the development and maintenance of chronic pain. In animal models of chronic pain, PBN neurons become sensitive to normally innocuous stimuli and responses to noxious stimuli become amplified and more often produce after-discharges t… Show more
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