Diuretics, Mortality, and Nonrecovery of Renal Function in Acute Renal Failure

Abstract

The use of diuretics in critically ill patients with acute renal failure was associated with an increased risk of death and nonrecovery of renal function. Although observational data prohibit causal inference, it is unlikely that diuretics afford any material benefit in this clinical setting. In the absence of compelling contradictory data from a randomized, blinded clinical trial, the widespread use of diuretics in critically ill patients with acute renal failure should be discouraged.

Effect of acute kidney injury on weaning from mechanical ventilation in chronic obstructive pulmonary diseases patients with respiratory failure

“…Santos and Magro demonstrate the effect PEEP in critically ill patients which can result in altered kidney function in patients in ICU [ 21 ]. This is also in agreement with Mehta et al who explained that a high rate of oliguria and the lower urinary volume in AKI patients probably contributed to positive net fluid balance, confirming recent findings on the effect of fluid balance on weaning [ 22 ].…”

Relationship of Urine Output to Dialysis Initiation and Mortality in Acute Renal Failure

“…However, a subset of patients within this group will not experience recovery and thus are destined to a prolonged and protracted course of uremic toxicity, subclinical or overt fluid overload, and electrolyte and acid-base imbalance only to ultimately be initiated on dialysis. The present study confirms recent studies indicating a delay in dialysis initiation among non-oliguric patients [5, 6]but in addition also shows a link to increased mortality.…”

Progression and outcomes of non‐dialysis dependent chronic kidney disease patients: A single center longitudinal follow‐up study

“…This leads to hemodynamically mediated nephrotoxicity . Similar findings are reported by Mehta et al and Butler et al in their nested control studies among hospitalized patients …”