Diuretic Effect of Prosopis farcta in Comparison with Spironolactone and Hydrochlorothiazide in Hypertensive Rats

M.Raoof, Zana; Dizaye, Kawa

doi:10.31351/vol29iss1pp226-235

Cited by 1 publication

(1 citation statement)

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“…As supplementary food or drink for feeding buffalo, deer, antelopes, and other animals, they have also been used to make gum, paint, cordage, and other items. Prosopis farcta L. treat a variety of illnesses and conditions, including colds, measles, urinary tract infections, diarrhea, and diseases associated with swollen tissues (Asadollahi et al, 2014, Raoof andDizaye, 2020). Fruits of Prosopis farcta L. have been used extensively in medicine as astringents, stomach tonics, blood coagulation agents, and anti-diarrheal (Safari et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Antidiarrheal Effects of Prosopis farcta L. Fruit Extract: An Enteropooling and Histopathological Study in Rats

H. Zughayyar,

H. Gyad

2023

AAVS

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The aim of this study was to examine the antidiarrheal activity of the alcoholic fruit extract of Prosopis farcta L. in a rat model. Thirty male Albion Wistar rats randomized into six equal groups of five as follows: negative control (received distilled water), positive control (induced diarrhea with 2 ml castor oil), and experimental groups that received 2 ml castor oil followed by oral administration of different doses of Prosopis farcta L. fruit ethanolic extract (300 mg/kg, 400 mg/kg, and 500 mg/kg). A comparative group received castor oil along with loperamide (2.5 mg/kg) orally. The outcomes demonstrated that after three hours, the castor oil-treated animals produced liquid feces. Enteropooling test findings revealed that castor oil generated an accumulation of water and electrolytes in the intestinal loop. Weight and volume of the intestine were reduced after treatment with the fruit extract of Prosopis farcta L. In contrast to loperamide, all groups intestinal contents varied significantly (P≤0.05) in volume and weight. Histopathological examinations of the duodenum corroborated the antidiarrheal efficacy of the extract. In contrast to the positive control group, which showed significant edema and inflammatory cell infiltration, rats treated with the Prosopis farcta L. fruit extract exhibited varying degrees of tissue recovery. Particularly, the group receiving 500 mg/kg showed mild lesions and lower inflammatory cell infiltration, closely resembling the histological profile of the loperamide-treated group. Subsequent phytochemical analysis revealed the presence of tannins, carbohydrates, phenols, resins, flavonoids, saponins, alkaloids, coumarins, terpenes, and glycosides, while steroids and proteins were absent. The extract displayed antidiarrheal activity comparable to loperamide, showing a significant reduction in intestinal content volume and weight (P≤0.05). In conclusion, the ethanolic extract of Prosopis farcta L. fruits demonstrated promising antidiarrheal activity, potentially due to the phytochemical constituents identified, warranting further research for clinical applications.

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Section: Introductionmentioning

confidence: 99%