Distribution pattern of amino acid mutations in chloroquine and antifolate drug resistance associated genes in complicated and uncomplicated Plasmodium vivax isolates from Chandigarh, North India

Kaur, Harpreet; Sehgal, Rakesh; Kumar, Archit; Bharti, Praveen K.; Bansal, Devendra; Mohapatra, Pradyumna K.; Mahanta, Jagadish; Sultan, Ali A.

doi:10.1186/s12879-020-05397-6

Cited by 10 publications

(16 citation statements)

References 42 publications

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“…Studies in India have also reported this double mutant. A study conducted in Chandigarh also had similar findings with 117/118 isolates (99%) having this double mutant [49]. A multicentric study done by Vamsi et al from different regions of India, such as, Puducherry, Mangaluru, Cuttack and Jodhpur revealed 91.6% of the isolates with mutations, T958M and F1076L [53].…”

Section: Cq-chloroquine In a Wild Type Plasmodium Vivax Infected Rbc ...supporting

confidence: 55%

“…The molecular markers for chloroquine resistance are mutations in the pvcrt-o and pvmdr1 genes. Insertion of lysine (AAG) at the 10th amino acid position (K 10 insertion) of exon1 of Pvcrt-o is the commonly reported mutation of the pvcrt-o gene and has been reported from India as well [48,49]. However, most of the K10 insertion that has been reported so far was from Myanmar (46-72%) and Thailand (56-89%) [50][51][52].…”

Section: Cq-chloroquine In a Wild Type Plasmodium Vivax Infected Rbc ...mentioning

confidence: 99%

“…Polymorphism at Y976F is said to be associated with a 1.7-fold increase in resistance to the drug [56]. The triple mutants carrying the Y976F mutation along with T958M and F1076L mutations have been reported from India though the double mutant T958M Y976F is not much reported [48,49]. Other mutations which are reported in the pvmdr1 gene are very rarely.…”

Section: Cq-chloroquine In a Wild Type Plasmodium Vivax Infected Rbc ...mentioning

confidence: 99%

“…Other mutations which are reported in the pvmdr1 gene are very rarely. They are at codons 946 (I946V) and 1028 (Y1028C) where isoleucine is replaced by Valine and tyrosine is replaced by cysteine respectively [48,49]. A study in Delhi by Matlani et.al has shown two novel mutations that have been exclusively reported.…”

Section: Cq-chloroquine In a Wild Type Plasmodium Vivax Infected Rbc ...mentioning

confidence: 99%

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Burden of Drug Resistance in vivax Malaria in India - A Brief Update

Stanley

Rajkumari

2023

IJTDH

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India contributes significantly to the global Plasmodium vivax burden. Treatment of malaria is more challenging than before owing to the rise of antimalarial drug resistance. The commonly used antimalarial drugs for treatment are chloroquine, antifolates like sulfadoxine-pyrimethamine, and artemisinin-based derivatives. Antimalarial resistance is studied by in vitro and in vivo methods. Study on mutations in the drug targets in the parasite is a widely used tool to help foresee likely resistance and relate to the clinical picture. The majority of studies on antimalarial resistance from the Southeast Asian region come from countries like Thailand and Myanmar. Though therapeutic failure with these antimalarial agents has not been reported in India, there have been reports of reduced clinical efficacy in the presence of mutations in their molecular targets.

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Section: Cq-chloroquine In a Wild Type Plasmodium Vivax Infected Rbc ...supporting

confidence: 55%

Section: Cq-chloroquine In a Wild Type Plasmodium Vivax Infected Rbc ...mentioning

confidence: 99%

Section: Cq-chloroquine In a Wild Type Plasmodium Vivax Infected Rbc ...mentioning

confidence: 99%

Section: Cq-chloroquine In a Wild Type Plasmodium Vivax Infected Rbc ...mentioning

confidence: 99%

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Burden of Drug Resistance in vivax Malaria in India - A Brief Update

Stanley

Rajkumari

2023

IJTDH

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“…Although chloroquine had been discontinued for nearly a decade, a higher abundance of mutated P. falciparum chloroquine-resistant transporter ( pfcrt ) and a lower prevalence of mutated P. falciparum multidrug resistance 1 ( pfmdr1 ), which confer resistance to chloroquine, were observed [ 74 , 75 ]. Mutant alleles of pvmdr1 gene were also observed among P. vivax from New Delhi Capital Region [ 76 ], Chandigarh in North India [ 77 ] and the southwestern coastal region in South India [ 78 ]. The presence of Kelch 13 mutations, which confer resistance to artemisinin-based combination therapy (such as artesunate/sulfadoxine/pyrimethamine), have also been reported from India [ 79 ].…”

Section: Malaria Status Among Countries Contributing Most Of the Imported Malaria Cases In Gcc Countriesmentioning

confidence: 99%

Current Epidemiological Characteristics of Imported Malaria, Vector Control Status and Malaria Elimination Prospects in the Gulf Cooperation Council (GCC) Countries

et al. 2021

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Malaria is the most common vector-borne parasitic infection causing significant human morbidity and mortality in nearly 90 tropical/sub-tropical countries worldwide. Significant differences exist in the incidence of malaria cases, dominant Plasmodium species, drug-resistant strains and mortality rates in different countries. Six Gulf Cooperation Council (GCC) countries (Bahrain, Kuwait, Qatar, Oman, Saudi Arabia and United Arab Emirates, UAE) in the Middle East region with similar climates, population demographics and economic prosperity are aiming to achieve malaria elimination. In this narrative review, all studies indexed in PubMed describing epidemiological characteristics of indigenous and imported malaria cases, vector control status and how malaria infections can be controlled to achieve malaria elimination in GCC countries were reviewed and discussed. These studies have shown that indigenous malaria cases are absent in Bahrain, Kuwait, Qatar and UAE and have progressively declined in Oman and Saudi Arabia. However, imported malaria cases continue to occur as GCC countries have large expatriate populations originating from malaria-endemic countries. Various malaria control and prevention strategies adopted by GCC countries including more stringent measures to reduce the likelihood of importing malaria cases by prior screening of newly arriving expatriates and vector elimination programs are likely to lead to malaria elimination in this region.

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Global scenario of Plasmodium vivax occurrence and resistance pattern

2022

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Malaria caused by Plasmodium vivax is comparatively less virulent than Plasmodium falciparum, which can also lead to severe disease and death. It shows a wide geographical distribution. Chloroquine serves as a drug of choice, with primaquine as a radical cure. However, with the appearance of resistance to chloroquine and treatment has been shifted to artemisinin combination therapy followed by primaquine as a radical cure. Sulphadoxine‐pyrimethamine, mefloquine, and atovaquone‐proguanil are other drugs of choice in chloroquine‐resistant areas, and later resistance was soon reported for these drugs also. The emergence of drug resistance serves as a major hurdle to controlling and eliminating malaria. The discovery of robust molecular markers and regular surveillance for the presence of mutations in malaria‐endemic areas would serve as a helpful tool to combat drug resistance. Here, in this review, we will discuss the endemicity of P. vivax, a historical overview of antimalarial drugs, the appearance of drug resistance and molecular markers with their global distribution along with different measures taken to reduce malaria burden due to P. vivax infection and their resistance.

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Distribution pattern of amino acid mutations in chloroquine and antifolate drug resistance associated genes in complicated and uncomplicated Plasmodium vivax isolates from Chandigarh, North India

Cited by 10 publications

References 42 publications

Burden of Drug Resistance in vivax Malaria in India - A Brief Update

Burden of Drug Resistance in vivax Malaria in India - A Brief Update

Current Epidemiological Characteristics of Imported Malaria, Vector Control Status and Malaria Elimination Prospects in the Gulf Cooperation Council (GCC) Countries

Global scenario of Plasmodium vivax occurrence and resistance pattern

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