Distribution of β2‐adrenergic receptor mRNA expression along the hamster nephron segments

Taniguchi, Shigeo; Watanabe, Tsuyoshi; Nakao, Akihide; Seki, George; Uwatoko, Shu; Suzuki, Keiji; Kurokawa, Kiyoshi

doi:10.1016/0014-5793(93)81329-x

Cited by 9 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous reports (34,35) demonstrated that renal ␤ 2 -AR in normal rats were predominantly localized to the apical and sub-apical compartments of proximal and, to a lesser extent, distal tubular epithelia and the membranes of smooth muscle cells from renal arteries. From this morphologic evidence, it was proposed that ␤ 2 -AR may regulate glomerular function and thereby sodium and water balance in the different nephron segments.…”

Section: Discussionmentioning

confidence: 87%

β2-Adrenoceptor Activation Attenuates Endotoxin-Induced Acute Renal Failure

Imaizumi¹,

Yanagawa²,

Kohsaka³

et al. 2004

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Abstract. Abnormalities in the ␤ 2 -adrenergic control of organ function have been implicated in the pathogenesis of several disease states, such as septic shock. The objectives of the present study were to define the contribution of ␤ 2 -adrenoceptors (␤ 2 -AR) to normal renal physiology and to investigate whether overexpression of renal ␤ 2 -AR might be potentially beneficial in preventing progressive renal damage associated with endotoxemia. Adenoviral transgenes containing the human ␤ 2 -AR (Adeno-␤ 2 -AR) were constructed and delivered into the rat kidney by means of intraparenchymal injections.

show abstract

Section: Discussionmentioning

confidence: 87%

β2-Adrenoceptor Activation Attenuates Endotoxin-Induced Acute Renal Failure

Imaizumi¹,

Yanagawa²,

Kohsaka³

et al. 2004

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…, 1994). Previous reports have demonstrated that renal β 2 ‐adrenergic receptors in normal rats were predominantly localized to the apical and sub‐apical compartments of proximal and, to a lesser extent, distal tubular epithelia and the membranes of smooth muscle cells from renal arteries (Taniguchi et al. , 1993; Boivin et al.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Ang II and renal sympathetic nerve influence dopamine‐and isoprenaline‐induced renal haemodynamic changes in normal Wistar–Kyoto and spontaneously hypertensive rats

Abdulla

Sattar

Abdullah

et al. 2008

Auton Autocoid Pharmacol

View full text Add to dashboard Cite

1. This study was undertaken to elucidate the effects of inhibiting the renin-angiotensin system (RAS) with losartan, and acute unilateral renal denervation on renal haemodynamic responses to intrarenal administration of vasoconstrictor doses of dopamine and vasodilator doses of isoprenaline in Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. Acute unilateral renal denervation of the left kidney in rats was confirmed by a drop in the renal vasoconstrictor response to renal nerve stimulation (P < 0.05) along with diuresis and natriuresis. Rats were pretreated with losartan for 7 days and thereafter animals fasted overnight were anaesthetized (sodium pentobarbitone, 60 mg/kg i.p.) and acute renal haemodynamic responses studied. 3. Dose-response curves were constructed for dopamine and isoprenaline that induced falls or increases in renal blood flow, respectively. It was observed that renal vascular responses were greater in the denervated as compared with rats with intact renal nerves (all P < 0.05). Dopamine-induced renal vasoconstrictor responses were markedly lower in losartan-treated denervated WKY and SHR compared with their untreated counterparts (all P < 0.05). It was also observed that in losartan-treated and denervated WKY rats the vasodilatory responses to isoprenaline were markedly lower compared with untreated rats (all P < 0.05). However, in SHR, under the same conditions, there was no difference in the renal response to isoprenaline whether or not rats were treated with losartan (P > 0.05). 4. The data obtained showed that the renal vasoconstrictor effect of dopamine depends on intact renal nerves and RAS in WKY and SHR. Isoprenaline responses were likewise sensitive to renal denervation and RAS inhibition in WKY rats but not SHRs. Our observations reveal a possible relationship between renal AT(1) receptors and alpha(1)-adrenoceptors in WKY and SHR. There is also evidence to suggest an interaction between renal beta-adrenoceptors and AT(1) receptors in WKY rats.

show abstract