Distribution of readiness potential, pre-motion positivity, and motor potential of the human cerebral cortex preceding voluntary finger movements

Deecke, Lüder; Scheid, P.; Kornhuber, H. H.

doi:10.1007/bf00235441

Cited by 660 publications

(291 citation statements)

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“…In conclusion, this study shows that the early components of the MRP or the Bereitshaftspotential (Deecke et al 1969) are reduced in individuals with HFA. Our MRP traces indicate that Bereitshaftspotentials are more severely impaired in individuals with autism relative to AD.…”

Section: Endsupporting

confidence: 49%

Movement-related potentials in high-functioning autism and Asperger's disorder

Rinehart

Tonge

Bradshaw

et al. 2006

Developmental Medicine &Amp; Child Neurology

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Autism and Asperger's disorder (AD) are neurodevelopmental conditions that affect cognitive and social‐communicative function. Using a movement‐related potential (MRP) paradigm, we investigated the clinical and neurobiological issue of ‘disorder separateness’ versus ‘disorder variance’ in autism and AD. This paradigm has been used to assess basal ganglia/supplementary motor functioning in Parkinson's disease. Three groups (high functioning autism [HFA]: 16 males, 1 female; mean age 12y 5mo [SD 4y 4mo]; AD: 11 males, 2 females; mean age 13y 5mo [SD 3y 8mo]; comparison group: 13 males, 8 females; mean age 13y 10mo [SD 3y 11mo]) completed a cued motor task during electroencephalogram recording of MRPs. The HFA group showed reduced peak amplitude at Cz, indicating less activity over the supplementary motor area during movement preparation. Although an overall significant between‐group effect was found for early slope and peak amplitude, sub‐analysis revealed that the group with AD did not differ significantly from either group. However, it is suggested that autism and AD may be dissociated on the basis of brain‐behaviour correlations of IQ with specific neurobiological measures. The overlap between MRP traces for autism and Parkinson's disease suggests that the neurobiological wiring of motor functioning in autism may bypass the supplementary motor area/primary motor cortex pathway.

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Section: Endsupporting

confidence: 49%

Movement-related potentials in high-functioning autism and Asperger's disorder

Rinehart

Tonge

Bradshaw

et al. 2006

Developmental Medicine &Amp; Child Neurology

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“…It has been shown that the 'bereitschaftspotential' , an electrophysiological marker of the readiness to act 86 , occurs not only when an individual actively performs a motor act, but also when the nature and the onset time of an upcoming action performed by another individual is predictable on the basis of a visual cue 87 .…”

Section: Motor Actionmentioning

confidence: 99%

The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations

2010

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“…Kornhuber and Deecke were the first to find that slow negative shifts of the cortical DC potential (Bereitschaftspotential, BP, or readiness potential) can be recorded long before the execution of motor tasks [12,13,29]. The BP, viewed as reflecting preparatory set and intention to act by these authors, has its maximum and earliest onset in fronto-central midline leads overlying the SMA and adjacent areas.…”

Section: Relation To Motor Preparationmentioning

confidence: 99%

Comparison of neuronal activity in the supplementary motor area and primary motor cortex

Tanji

Mushiake

1996

Cognitive Brain Research

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Neuronal activity in the supplementary motor area (SMA) and primary motor cortex (MI) have been compared in many experiments during performance of many different motor tasks. On one hand, the activity in both areas may appear similar, especially when the motor task is simple. On the other hand, if the motor tasks are more demanding, neuronal activity in the SMA exhibits a variety of complex relationship to many different aspects of motor behavior, while the activity in MI is mostly related to execution of motor task itself. Of particular interest is the neuronal activity in the SMA during preparation and execution of motor tasks when no external cues for the retrieval of appropriate motor act is available. Temporal sequencing of multiple movements is a typical example of the kind of motor task that requires profound activity in the SMA.Keywords: Supplementary motor area (SMA); Primary motor cortex (MI); Pre-SMA; Motor preparation; Motor sequence; Subhuman primate New concepts of motor areas in the medial frontal cortexUntil recently, only one motor representation area was known to exist in the medial part of the frontal lobe, as described in classical reports [55,80]. However, it is now proposed that at least four somatomotor fields and one oculomotor field exist in the medial frontal cortex. [65]. Traditionally, the supplementary motor area (SMA) has been defined as a single motor area in the frontal agranular cortex, corresponding to medial part of Brodmann's area 6. However, some indications for possible existence of heterogeneity in this region has been obtained [2,15,25,42]. On the basis of cytoarchitectonic analysis combined with cytochrome oxidase histochemistry and detailed ICMS studies, Rizzolatti and coworkers proposed a view that two motor areas exist in the region of the cortex traditionally defined as the SMA [41,44]. They termed the rostral and caudal areas as F6 and F3, largely corresponding to 6ab and 6aa of Vogts [78]. They also reported the existence of neuronal activity characteristic in mesial 6ab, namely, the activity during arm reaching-grasping movements [57]. Systematic attempts were made in our laboratory to determine whether it is possible to define two different areas unequivocally by a battery of physiological tests [45]. By implanting electrodes into the forelimb area of the MI, we found that field and unitary responses to electrical stimulation were distinct in the caudal part of mesial area 6, but not in the rostral part. The caudal part was distinctly more microexcitable by the ICMS than the rostral part. Neuronal responses to visual stimuli prevailed in the rostral part, but somatosensory responses were rare. The opposite was true in the caudal part [24,79]. Furthermore, single-unit activity during performance of a trained motor task was quantitatively analyzed and compared in the same individuals. Phasic responses to visual cue signals indicating the direction of forthcoming arm-reaching movement were more abundant in the rostral part. Neuronal activity changes during th...

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Distribution of readiness potential, pre-motion positivity, and motor potential of the human cerebral cortex preceding voluntary finger movements

Cited by 660 publications

References 3 publications

Movement-related potentials in high-functioning autism and Asperger's disorder

Movement-related potentials in high-functioning autism and Asperger's disorder

The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations

Comparison of neuronal activity in the supplementary motor area and primary motor cortex

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