Distribution of PSA-NCAM in normal, Alzheimer’s and Parkinson’s disease human brain

Murray, Helen C.; Low, Victoria F.; Swanson, Molly E. V.; Dieriks, Birger; Turner, Clinton; Faull, Richard L.M.; Curtis, Maurice A.

doi:10.1016/j.neuroscience.2016.06.003

Cited by 44 publications

(26 citation statements)

References 73 publications

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“…In particular, astrocytes are responsible for the largest production of the most abundant apoE-containing HDL-like lipoproteins that redistribute lipids in the central nervous system. Further studies are needed to examine the potential role of brain PSA, whose expression declines in Alzheimer's disease (Murray et al, 2016), in the maintenance of cholesterol homeostasis in the central compartment as well.…”

Section: Discussionmentioning

confidence: 99%

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus

et al. 2017

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The polysialic acid (PSA) is a large glycan that is added to cell-surface proteins during their post-translational maturation. In the brain, PSA modulates distances between cells and controls the plasticity of the nervous system. In the hypothalamus, PSA is involved in many aspects of energy balance including food intake, osmoregulation, circadian rhythm, and sleep. In this work, we investigated the role of hypothalamic PSA in the regulation of plasma cholesterol levels and distribution. We report that HFD consumption in mice rapidly increased plasma cholesterol, including VLDL, LDL, and HDL-cholesterol. Although plasma VLDL-cholesterol was normalized within the first week, LDL and HDL were still elevated after 2 weeks upon HFD. Importantly, we found that hypothalamic PSA removal aggravated LDL elevation and reduced HDL levels upon HFD. These results indicate that hypothalamic PSA controls plasma lipoprotein profile by circumventing the rise of LDL-to-HDL cholesterol ratio in plasma during overfeeding. Although mechanisms by which hypothalamic PSA controls plasma cholesterol homeostasis remains to be elucidated, these findings also suggest that low level of hypothalamic PSA might be a risk factor for dyslipidemia and cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus

et al. 2017

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“…Similar findings were reported for cats (Varea et al., ). PSA‐NCAM is also present in layer II‐neurons of human EC (Murray et al., , ; Varea et al., ), where its presence is limited to GAD+ neurons co‐labelling with either CB+, CR+ or PV+, typically of a small bi‐or multipolar morphology (Murray et al., , ).…”

Section: Layer IImentioning

confidence: 99%

“…Regarding the short PV+ chandelier‐like terminals present in layer III across species, these selectively label positive for PSA‐NCAM and GAT1, at least in humans (Arellano et al., ; DeFelipe & Gonzalez‐Albo, ). Moreover, PSA‐NCAM is expressed on the somata of a minor population of layer III‐neurons in rats (Foley et al., ; Fox et al., ; Gomez‐Climent et al., ), cats (Varea et al., ) and humans (Murray et al., , ; Varea et al., ). As for layer II (see above), work on human EC shows that PSA‐NCAM in layer III is selectively present in GAD+ neurons, co‐labels with either CB+, CR+ or PV+, and typically associate with neurons having a small bi‐or multipolar morphology (Murray et al., , ).…”

Section: Layer IIImentioning

confidence: 99%

“…Moreover, PSA‐NCAM is expressed on the somata of a minor population of layer III‐neurons in rats (Foley et al., ; Fox et al., ; Gomez‐Climent et al., ), cats (Varea et al., ) and humans (Murray et al., , ; Varea et al., ). As for layer II (see above), work on human EC shows that PSA‐NCAM in layer III is selectively present in GAD+ neurons, co‐labels with either CB+, CR+ or PV+, and typically associate with neurons having a small bi‐or multipolar morphology (Murray et al., , ). Also, most, if not all PV+ neurons in layer III (as in the other cell layers) express m2AChR (Chaudhuri et al., ).…”

Section: Layer IIImentioning

confidence: 99%

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Neuronal chemo‐architecture of the entorhinal cortex: A comparative review

Kobro‐Flatmoen

2019

Eur J of Neuroscience

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The identification of neuronal markers, that is, molecules selectively present in subsets of neurons, contributes to our understanding of brain areas and the networks within them. Specifically, recognizing the distribution of different neuronal markers facilitates the identification of borders between functionally distinct brain areas. Detailed knowledge about the localization and physiological significance of neuronal markers may also provide clues to generate new hypotheses concerning aspects of normal and abnormal brain functioning. Here, we provide a comprehensive review on the distribution within the entorhinal cortex of neuronal markers and the morphology of the neurons they reveal. Emphasis is on the comparative distribution of several markers, with a focus on, but not restricted to rodent, monkey and human data, allowing to infer connectional features, across species, associated with these markers, based on what is revealed by mainly rodent data. The overall conclusion from this review is that there is an emerging pattern in the distribution of neuronal markers in the entorhinal cortex when aligning data along a comparable coordinate system in various species.

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“…The modulation of the polysialylation has been discussed for the treatment of different neurodegenerative diseases and as general tool for neuro‐regeneration . Reduced polysialylation has been described for patients with Parkinson's and Alzheimer's diseases and in schizophrenia . We also found an increase in cell‐surface sialylation on leucocytes from sialuria mice.…”

Section: Discussionmentioning

confidence: 53%

Increased Polysialylation of the Neural Cell Adhesion Molecule in a Transgenic Mouse Model of Sialuria

et al. 2017

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Distribution of PSA-NCAM in normal, Alzheimer’s and Parkinson’s disease human brain

Cited by 44 publications

References 73 publications

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus

Neuronal chemo‐architecture of the entorhinal cortex: A comparative review

Increased Polysialylation of the Neural Cell Adhesion Molecule in a Transgenic Mouse Model of Sialuria

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