Distribution of Protein Gene Product 9.5-Immunopositive and NADPH-Diaphorase-Positive Neurons in the Common Marmoset (Callithrix jacchus) Accessory Olfactory Bulb

Nakajima, Takayuki; Tanioka, Yoshikuni; Taniguchi, Kazuyuki

doi:10.1292/jvms.65.1307

Cited by 3 publications

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References 33 publications

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“…Specifically, PGP is expressed in rodent (Johnson et al, 1994) and canine (Dennis et al, 2003) VNNE as well as rodent, canine, and marmoset accessory olfactory bulb (Taniguchi et al, 1993;Johnson et al, 1994;Nakajima et al, 1998aNakajima et al, , 1998bNakajima et al, , 2003. OMP is a phylogenetically highly conserved cytoplasmic protein expressed by mature olfactory chemosensory neurons of the MOE and VNO (Margolis, 1972(Margolis, , 1980Farbman and Margolis, 1980).…”

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confidence: 99%

Expression of neuron‐specific markers by the vomeronasal neuroepithelium in six species of primates

et al. 2004

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Vomeronasal organ (VNO) morphology varies markedly across primate taxa. Old World monkeys display no postnatal VNO. Humans and at least some apes retain a vestigial VNO during postnatal life, whereas the strepsirrhines and New World Monkeys present a morphologically well-defined VNO that, in many species, is presumed to function as an olfactory organ. Available microanatomical and behavioral studies suggest that VNO function in these species does not precisely duplicate that described in other mammalian taxa. The questions of which species retain a functional VNO and what functions they serve require inquiry along diverse lines but, to be functional, the vomeronasal epithelium must be neuronal and olfactory. We used immunohistochemistry to establish these criteria in six primate species. We compared the expression of two neuronal markers, neuron-specific ␤-tubulin (BT) and protein gene product 9.5, and olfactory marker protein (OMP), a marker of mature olfactory sensory neurons, in paraffin-embedded VNO sections from two strepsirrhine and four haplorhine species, all of which retain morphologically well-defined VNOs during postnatal life. The infant Eulemur mongoz, adult Otolemur crassicaudatus, neonatal Leontopithicus rosalia, and adult Callithrix jacchus express all three proteins in their well-defined vomeronasal neuroepithelia. The infant Tarsius syrichta showed some BT and OMP immunoreactivity. We establish that two strepsirrhine species and at least some New World haplorhines have mature sensory neurons in the VNO. In contrast, at all ages examined, Saguinus geoffroyi VNO expresses these markers in only a few cells. © 2004 Wiley-Liss, Inc.Key words: immunohistochemistry; olfaction; olfactory marker protein; primate; ␤-tubulin; PGP 9.5; vomeronasalThe tetrapod vomeronasal organ (VNO) is bilaterally symmetric and lies along the ventrorostral aspect of the nasal septum. Sensory neurons in the vomeronasal neuroepithelium (VNNE) of snakes, rodents, and opossums detect chemical signals that evoke behavioral and/or physiological changes regarding prey identification, social status, and reproductive state (Wysocki, 1979;Halpern, 1987;Takami, 2002;Halpern and Martínez-Marcos, 2003).The rodent VNO is the best studied in terms of gene expression during development, its morphological organization, its secondary and higher-order connections, and its effects on the organism's behavior and physiology. For some time, the rodent VNO was thought to epitomize the mammalian vomeronasal system but VNO function as exemplified in rodents is not precisely replicated in other mammalian taxa, namely, ferrets (Weiler et al., 1999;

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confidence: 99%

Expression of neuron‐specific markers by the vomeronasal neuroepithelium in six species of primates

et al. 2004

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“…In rodents, the olfactory glomeruli have less‐defined architecture, although two subsets in the anterior and posterior parts of the accessory olfactory bulbs are conserved (Ichikawa et al, 1992). The accessory olfactory bulb in a New World monkey, common marmoset ( Callithrix jacchus ), exist as a small area at the dorsal side of the caudal end of the olfactory bulb, shows diffuse laminar structure and no functional divergence (Nakajima et al, 2003). The absence of the accessory olfactory bulb in the barfin flounder and the presence of olfactory glomeruli with different carbohydrate moieties were demonstrated in this study, suggesting that the glomerular layer of the fish may be divided into subcompartments, including a particular region and/or a group of olfactory glomeruli which might serve as an accessory olfactory bulb.…”

Section: Discussionmentioning

confidence: 99%

Lectin Histochemical Analysis of the Olfactory Bulbs in the Barfin Flounder (Verasper moseri)

Nakamuta¹,

Yokoyama²,

Yamamoto³

et al. 2010

Anat Histol Embryol

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Summary Several lines of evidence have shown that the olfactory system of the fish contains the main and accessory olfactory systems. However, morphological data indicate that the accessory olfactory bulb, the primary centre for the accessory olfactory system, will not differentiate in the fish. Therefore, the fish olfactory bulb is supposed to engage in both main and accessory olfactory systems. To examine this possibility, we investigated the olfactory bulb of the barfin flounder (Verasper moseri) by histochemical examination using lectins. The olfactory bulb of the barfin flounder showed a laminar structure with four layers, and diffuse glomerular architecture was observed in the glomerular layer. Based on the expression patterns of sugar residues, the glomerular layer of the barfin olfactory bulb was largely divided into three portions. Heterogeneity in the lectin‐binding pattern among olfactory glomeruli was clearly demonstrated by the fluorescent double‐lectin staining. The results of this study suggest that the fish olfactory bulb contains both regions equivalent to the main and accessory olfactory bulbs, and they are subdivided into small subsets with different functions.

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“…Neuron-specific markers have been reported to be expressed in the vomeronasal epithelium of different species of primates including marmoset (Dennis et al, 2004). Neurons in the AOB express markers typical of mitral/tufted cells (Nakajima et al, 2003). Marmoset, like other mammals and in contrast to rodents and opossums, display a homogeneous vomeronasal system where only V1R and Gi proteins are expressed (Takigami et al, 2004).…”

Section: Taxonomic Overview Of Vertebratesmentioning

confidence: 99%

Cladistic Analysis of Olfactory and Vomeronasal Systems

Úbeda-Bañón¹,

Pro-Sistiaga²,

Mohedano-Moriano³

et al. 2011

Front. Neuroanat.

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Most tetrapods possess two nasal organs for detecting chemicals in their environment, which are the sensory detectors of the olfactory and vomeronasal systems. The seventies’ view that the olfactory system was only devoted to sense volatiles, whereas the vomeronasal system was exclusively specialized for pheromone detection was challenged by accumulating data showing deep anatomical and functional interrelationships between both systems. In addition, the assumption that the vomeronasal system appeared as an adaptation to terrestrial life is being questioned as well. The aim of the present work is to use a comparative strategy to gain insight in our understanding of the evolution of chemical “cortex.” We have analyzed the organization of the olfactory and vomeronasal cortices of reptiles, marsupials, and placental mammals and we have compared our findings with data from other taxa in order to better understand the evolutionary history of the nasal sensory systems in vertebrates. The olfactory and vomeronsasal cortices have been re-investigated in garter snakes (Thamnophis sirtalis), short-tailed opossums (Monodelphis domestica), and rats (Rattus norvegicus) by tracing the efferents of the main and accessory olfactory bulbs using injections of neuroanatomical anterograde tracers (dextran-amines). In snakes, the medial olfactory tract is quite evident, whereas the main vomeronasal-recipient structure, the nucleus sphaericus is a folded cortical-like structure, located at the caudal edge of the amygdala. In marsupials, which are acallosal mammals, the rhinal fissure is relatively dorsal and the olfactory and vomeronasal cortices relatively expanded. Placental mammals, like marsupials, show partially overlapping olfactory and vomeronasal projections in the rostral basal telencephalon. These data raise the interesting question of how the telencephalon has been re-organized in different groups according to the biological relevance of chemical senses.

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Distribution of Protein Gene Product 9.5-Immunopositive and NADPH-Diaphorase-Positive Neurons in the Common Marmoset (Callithrix jacchus) Accessory Olfactory Bulb

Cited by 3 publications

References 33 publications

Expression of neuron‐specific markers by the vomeronasal neuroepithelium in six species of primates

Expression of neuron‐specific markers by the vomeronasal neuroepithelium in six species of primates

Lectin Histochemical Analysis of the Olfactory Bulbs in the Barfin Flounder (Verasper moseri)

Cladistic Analysis of Olfactory and Vomeronasal Systems

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