Distribution of preproenkephalin, preprotachykinin A, and preprodynorphin mRNAs in the rat nucleus accumbens: Effect of repeated administration of nicotine

Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum

“…Whether nicotine affects dynorphinergic function in the striatum is unclear. Contrary to reports from chronic nicotine studies evaluating prodynorphin (PD) mRNA expression (Mathieu et al 1996;Mathieu-Kia and Besson 1998;Le Foll et al 2003), we have reported that the synthesis and release of Dyn are enhanced in the caudate/ putamen and nucleus accumbens of nicotine-dependent and withdrawn mice (Isola et al 2008) and suggested that Dyn might contribute to the emergence of the negative affective states associated with nicotine withdrawal (Kenny and Markou 2001).…”

Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum

“…Whether nicotine affects dynorphinergic function in the striatum is unclear. Contrary to reports from chronic nicotine studies evaluating prodynorphin (PD) mRNA expression (Mathieu et al 1996;Mathieu-Kia and Besson 1998;Le Foll et al 2003), we have reported that the synthesis and release of Dyn are enhanced in the caudate/ putamen and nucleus accumbens of nicotine-dependent and withdrawn mice (Isola et al 2008) and suggested that Dyn might contribute to the emergence of the negative affective states associated with nicotine withdrawal (Kenny and Markou 2001).…”

Nicotine addiction: insights from recent animal studies

“…However, some studies have reported that administration of nicotine for 2 weeks produced an increase in preproenkephalin mRNA levels 24 h following the final injection. Preproenkephalin is the peptide precursor for Leu-and Metenkephalins, two biologically active opioid peptides found in both the striatum (Dhatt et al 1995;Houdi et al 1998) and the nucleus accumbens (e.g., Mathieu et al 1996). Similar increases have also been described in the hippocampus (Houdi et al 1998).…”

Pup defence in lactating rats: The underlying neuropeptide signalling and their interactions in the nucleus accumbens shell

“…Several studies postulate a neurochemical or receptor gradient that differs along the rostro-caudal axis of the rat NAc (Mathieu et al, 1996; Ranaldi and Beninger, 1994; Rogard et al, 1993; Voorn and Docter, 1992). Here, we characterized the neurochemical properties and distribution of Crh-r expressing cells throughout the NAc of lactating rats.…”

Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum

“…Whether nicotine affects dynorphinergic function in the striatum is unclear. Contrary to reports from chronic nicotine studies evaluating prodynorphin (PD) mRNA expression (Mathieu et al 1996;Mathieu-Kia and Besson 1998;Le Foll et al 2003), we have reported that the synthesis and release of Dyn are enhanced in the caudate/ putamen and nucleus accumbens of nicotine-dependent and withdrawn mice (Isola et al 2008) and suggested that Dyn might contribute to the emergence of the negative affective states associated with nicotine withdrawal (Kenny and Markou 2001).…”

Nicotine addiction: insights from recent animal studies

“…However, some studies have reported that administration of nicotine for 2 weeks produced an increase in preproenkephalin mRNA levels 24 h following the final injection. Preproenkephalin is the peptide precursor for Leu-and Metenkephalins, two biologically active opioid peptides found in both the striatum (Dhatt et al 1995;Houdi et al 1998) and the nucleus accumbens (e.g., Mathieu et al 1996). Similar increases have also been described in the hippocampus (Houdi et al 1998).…”

Pup defence in lactating rats: The underlying neuropeptide signalling and their interactions in the nucleus accumbens shell

“…Several studies postulate a neurochemical or receptor gradient that differs along the rostro-caudal axis of the rat NAc (Mathieu et al, 1996; Ranaldi and Beninger, 1994; Rogard et al, 1993; Voorn and Docter, 1992). Here, we characterized the neurochemical properties and distribution of Crh-r expressing cells throughout the NAc of lactating rats.…”

Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum

“…Whether nicotine affects dynorphinergic function in the striatum is unclear. Contrary to reports from chronic nicotine studies evaluating prodynorphin (PD) mRNA expression (Mathieu et al 1996;Mathieu-Kia and Besson 1998;Le Foll et al 2003), we have reported that the synthesis and release of Dyn are enhanced in the caudate/ putamen and nucleus accumbens of nicotine-dependent and withdrawn mice (Isola et al 2008) and suggested that Dyn might contribute to the emergence of the negative affective states associated with nicotine withdrawal (Kenny and Markou 2001).…”

Nicotine addiction: insights from recent animal studies

“…However, some studies have reported that administration of nicotine for 2 weeks produced an increase in preproenkephalin mRNA levels 24 h following the final injection. Preproenkephalin is the peptide precursor for Leu-and Metenkephalins, two biologically active opioid peptides found in both the striatum (Dhatt et al 1995;Houdi et al 1998) and the nucleus accumbens (e.g., Mathieu et al 1996). Similar increases have also been described in the hippocampus (Houdi et al 1998).…”

Pup defence in lactating rats: The underlying neuropeptide signalling and their interactions in the nucleus accumbens shell

“…Several studies postulate a neurochemical or receptor gradient that differs along the rostro-caudal axis of the rat NAc (Mathieu et al, 1996; Ranaldi and Beninger, 1994; Rogard et al, 1993; Voorn and Docter, 1992). Here, we characterized the neurochemical properties and distribution of Crh-r expressing cells throughout the NAc of lactating rats.…”