2018
DOI: 10.3390/v10020066
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Abstract: The porcine cytomegalovirus (PCMV) is a herpesvirus that may pose a risk for xenotransplantation using pig cells, tissues, or organs. Here, three orthotopic pig heart transplantations into baboons were studied. To detect PCMV, a real-time PCR and a Western blot assay based on four PCMV protein sequences, including two tegument proteins, were used. The transmission of PCMV from the donor pig to the recipient baboon was found in two cases, despite PCMV not being detected in the blood of the donor pigs by real-ti… Show more

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Cited by 27 publications
(34 citation statements)
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(59 reference statements)
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“…As an example we illustrate in Figure 1 the pair donor pig 6249 and the recipient baboon P. All other animals analysed had a similar pattern. With exception of the skin, the viral load was high in all baboon organs (spleen, liver, muscle, kidney lung and lymph nodes) and donor pig organs (lung, spleen, liver, kidney and PBMCs), in agreement with previous results 27 . The highest viral load was found in the explanted pig heart ( Figure 1).…”
Section: Distribution Of Pcmv/prv In Pig and Baboon Organssupporting
confidence: 92%
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“…As an example we illustrate in Figure 1 the pair donor pig 6249 and the recipient baboon P. All other animals analysed had a similar pattern. With exception of the skin, the viral load was high in all baboon organs (spleen, liver, muscle, kidney lung and lymph nodes) and donor pig organs (lung, spleen, liver, kidney and PBMCs), in agreement with previous results 27 . The highest viral load was found in the explanted pig heart ( Figure 1).…”
Section: Distribution Of Pcmv/prv In Pig and Baboon Organssupporting
confidence: 92%
“…All baboons used in these investigations carried BaCMV, which is common in baboons. In one case a strong activation of BaCMV after transplantation of a PCMV-positive pig heart was observed (baboon I) 27 . In all other cases a direct activation of BaCMV could not be observed.…”
Section: Discussionmentioning
confidence: 99%
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