Distribution of hepatitis C genotypes in Uttar Pradesh, India; rare genotype 4 detected

Prakash, Shantanu; Shukla, Suruchi; Ramakrishna, Vangala; Jain, Amita

doi:10.1002/jmv.25277

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…7 HCV GT-3 is the second most prevalent genotype worldwide, but the prevalence of GT-3 in this study was highest i.e., 83%. Previous data shows that GT-4 was very rare with detection rates of less than 0.5% in the subcontinent 8 , however its prevalence in this study was 3.7%. Perhaps it was under diagnosed previously or maybe it is emerging as a new cause of chronic HCV now.…”

Section: Discussioncontrasting

confidence: 83%

Effectiveness of Sofosbuvir and Daclatasvir in treatment of Hepatitis-C: An experience of tertiary care hospital in Karachi

Butt¹,

Saleem

Khan³

et al. 2021

Pak J Med Sci

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Objective: To assess the effectiveness of Sofosbuvir (SOF) and Daclatasvir (DCV) in patients with chronic hepatitis C (CHC), compensated cirrhosis (CC) and decompensated cirrhosis (DCLD) either treatment naïve or experienced. Methods: This was a prospective, observational study, conducted from January 2017 to December 2018 at Jinnah Postgraduate Medical Centre, Karachi. All patients above 12 years of age with detectable HCV RNA PCR were included. Patients were divided into three groups: CHC, CC and DCLD. SOF and DCV for 12 or 24 weeks were given. Ribavirin (RBV) was given to treatment experienced and cirrhotic patients. Primary outcome was End of Treatment Response (ETR) and secondary outcome was Sustained Virological Response (SVR) at post treatment week 12 or 24. Results: Total 300 patients with mean age of 40.49 ± 13.86 were enrolled. Majority were females 174 (58%). CHC were 200 (66.6%) while cirrhotic were 100 (33.4%). Treatment naïve patients were 267 (89%) and 33 (11%) patients were experienced. Most common genotype was 3 (83%). ETR was achieved in 292 (97.33%) and SVR in 265 (88.33%) patients respectively. Conclusion: SOF plus DCV with or without RBV is a highly effective treatment for chronic HCV and is still used in many centers of Pakistan. This regimen has excellent results for GT-3. The outcomes are mainly influenced by the presence or absence of cirrhosis. doi: https://doi.org/10.12669/pjms.37.7.4627 How to cite this:Butt N, Anoshia, Khan MA, Akbar A. Effectiveness of Sofosbuvir and Daclatasvir in treatment of Hepatitis-C: An experience of tertiary care hospital in Karachi. Pak J Med Sci. 2021;37(7):2014-2019. doi: https://doi.org/10.12669/pjms.37.7.4627 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussioncontrasting

confidence: 83%

Effectiveness of Sofosbuvir and Daclatasvir in treatment of Hepatitis-C: An experience of tertiary care hospital in Karachi

Butt¹,

Saleem

Khan³

et al. 2021

Pak J Med Sci

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“…Many studies reported an association between injections drug user (IDU), female sex workers (FSW), men sex with men (MSM) and HCV, and some study reported associated risk patient; β-thalassemia, visceral leishmaniasis, jaundice, dialysis, three studies combined measure 12% prevalence in pregnant women, and also reported slum population and primitive groups with 6% prevalence (Table 2). 1,4,8,[14][15][16][17][18][19]20,22,23…”

Section: Resultsmentioning

confidence: 99%

Community-based transmission of hepatitis C in India: a systematic review

Husain

Akinola

Kaushik

2021

Int J Community Med Public Health

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To analyze the transmission of hepatitis C available studies differentiate state/province from the Indian region. In this review it has been described that there is strong association among the factors responsible for hepatitis C virus (HCV) transmission and community-based complex intervention within public health. Total 25 most relevant articles included in this review for Uttar Pradesh, Punjab, Tamil Nadu, Haryana, Odisha, West Bengal, Uttarakhand, and Gujarat. This systematic review followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The general concepts and topics covered by PRISMA are all relevant to any systematic review. All articles published before September 2020 that the electronic databases used in this search needed to draw content from the fields of tropical medicine, infectious disease, gastroenterology, sexually transmitted disease, communicable disease, family medicine physicians, public health and hepatology The respondent population was 104776 categorised into five major groups; general population, underprivileged population, associated risk patient, risk behavior group. We investigated an effective cluster, and random population from various locations, prevalence in community groups. Recommendation of this review is to develop a standardized public health structure between primary health-care providers in rural and urban populations, prevent infected blood transmission and proper screening of high-risk groups.

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“…5 A study conducted in Uttar Pradesh by Prakash et al reported that the prevalent genotypes and subtypes of HCV was found to be 25%, 2.9%, 0.25%, 68.07%, 2.2%, 0.49%, 0.74% and 0.24% for the genotypes 1a, GT1b, GT1c, GT3a, GT3b, GT3g, GT3i and GT4a, respectively. 14 Whereas HCV genotypes GT2, GT5 and GT6 were not detected in that population and GT3a and GT1b were the commonest.…”

Section: Hcv Genomementioning

confidence: 86%

Genotype-8: A Modern Family Member of Hepatitis C Virus

Gudi¹,

Chhabra²,

Rashid³

2019

IJPER

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Hepatitis C Virus (HCV) is a highly diverse and pervasive disease around the globe, with a prevalence ranging from 1.5 to 2.3%. With wide genetic variability, it is classified into seven Genotypes (GT) with 67 subtypes. The sighting of a modern HCV GT-8 ratifies its endemic character in India, particularly in the Punjab State. Getting familiarized and making aware of the HCV genotypes and subtypes is necessarily essential in establishing the optimal treatment regimen.

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Distribution of hepatitis C genotypes in Uttar Pradesh, India; rare genotype 4 detected

Abstract: HCV GTs 3a and 1a are the commonest circulating GTs in Uttar Pradesh, India.

Cited by 12 publications

References 25 publications

Effectiveness of Sofosbuvir and Daclatasvir in treatment of Hepatitis-C: An experience of tertiary care hospital in Karachi

Effectiveness of Sofosbuvir and Daclatasvir in treatment of Hepatitis-C: An experience of tertiary care hospital in Karachi

Community-based transmission of hepatitis C in India: a systematic review

Genotype-8: A Modern Family Member of Hepatitis C Virus

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