Distribution of class I and class III MHC antigens in the Tarasco Amerindians

Loeza, Francisco; Vargas‐Alarcón, Gilberto; Andrade, Felipe; Vergara, Y; Rodrı́guez-Pérez, José Manuel; Ruiz-Morales, Jorge A.; Alarcón‐Segovia, Donato; Granados, Julio

doi:10.1016/s0198-8859(01)00371-8

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…The sample from Michoacán showed similar distances from all the samples included in this study, possibly indicating a high degree of admixture or a distinct indigenous origin. The Tarascans, also known as the Purépecha, were historically a culturally and linguistically isolated group (Malmström, 1995;Loeza et al, 2002). The origins of this group have been traced as far back as the first century BC, and skills in war techniques protected them from the Aztecs, leading to cultural isolation (Loeza et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The Tarascans, also known as the Purépecha, were historically a culturally and linguistically isolated group (Malmström, 1995;Loeza et al, 2002). The origins of this group have been traced as far back as the first century BC, and skills in war techniques protected them from the Aztecs, leading to cultural isolation (Loeza et al, 2002). In addition, the Tarascans have a linguistic link to the Andean region of South America.…”

Section: Discussionmentioning

confidence: 99%

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A Geometric Morphometric Study of Regional Craniofacial Variation in Mexico

Humphries

Maxwell

Ross

et al. 2013

Int. J. Osteoarchaeol.

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Spanish speaking populations in the USA have long been categorised under the umbrella term ‘Hispanic’, which is a cultural construct. The term Hispanic ignores the unique ethnohistories and biological variation among Hispanic groups with various European, African and indigenous American influences. Considerable heterogeneity has been identified in pre‐contact America and has continued to influence the cultural and biological compositions of various regions today. The purpose of this research is to examine biological variation in Mexico, which was influenced by indigenous migration patterns and the Old World conquests of the Americans. Using multivariate statistics, this paper compares 16 three‐dimensional craniometric landmarks of samples from northern Central Mexico, northern Yucatan and western Mexico to examine the regional biological variation present in Mexico in both prehistoric and historic groups and also compares Mexican, Spanish and African American groups to examine patterns of Old World conquests. Multivariate statistics detected significant group differences for both size and shape (centroid size, p < 0.0001; shape, p < 0.0001) and showed that while significantly different, all the Mexican groups are more similar to one another except for one prehistoric inland‐western Mexican group, which is morphologically distinct from the other Mexican groups. Previous mtDNA research in these areas shows a low prevalence of African American admixture and a high indigenous component in the northern Mexican groups, which is consistent with the findings of this paper. The prehistoric and historic Mexican groups were the most similar indicating the retention of indigenous admixture after contact. The results from this analysis demonstrate that all groups are significantly different from one another supporting other findings that have shown that the indigenous populations of the New World are heterogeneous and that this variation may also contribute to the heterogeneity of contemporary populations. Copyright © 2013 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Geometric Morphometric Study of Regional Craniofacial Variation in Mexico

Humphries

Maxwell

Ross

et al. 2013

Int. J. Osteoarchaeol.

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“…The HLA system is bearer of the largest allelic polymorphism of all human genetic systems. However, several studies of HLA alleles in Native Americans have shown that these populations present limited polymorphism in this system as compared to Caucasian populations (Arnaiz-Villena et al 2000Loeza et al, 2002). The present study was made in an isolated ethnic group from Mexico.…”

Section: Resultsmentioning

confidence: 89%

HLA-Class II Genes in Mexican Amerindian Mayas: Relatedness with Guatemalan Mayans and Other Populations

Vargas‐Alarcón

Granados

Pérez-Hernández

et al. 2010

Immunological Investigations

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We analyzed the HLA class II allele frequencies in 50 healthy unrelated Mayan individuals. The relationship with other worldwide populations was studied by using HLA data from 71 different populations. The most frequent alleles were HLA-DRB1*04, HLA-DRB1*01, HLA-DQB1*0302 and HLA-DQB1*0501. When comparisons with other Mexican Amerindian groups were made, some differences were observed. Mayans showed an increased frequency of HLA-DRB1*01 when compared to Nahuas, Mayos, Teenek and Mazatecans (p < 0.05), whereas the HLA-DRB1*04 was increased in Mayans when compared to Nahuas (p < 0.05). The analysis of HLA-DQB1 alleles showed an increased frequency of DQB1*0302 in Mayans when compared to Nahuas and Mazatecans (p < 0.05), whereas the frequency of HLA-DQB1*0301 was decreased in Mayans when compared to Nahuas, Mayos, Teenek and Mazatecans (p < 0.05).

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“…According to the IMGT/HLA database (www.ebi.ac.uk/imgt/hla/stats.html), a total of 1,582 alleles have been identifĳied for the HLA-DRB1 locus and 712 for the HLA-DQB1 locus. At a continental level, American indigenous populations exhibit reduced genetic diversity at the HLA-DRB1 locus while also exhibiting a number of unique alleles (Watkins et al 1992;Cerna et al 1993;Yunis et al 1994;Trachtenberg et al 1996;Erlich et al 1997;Fernández-Viña et al 1997;Parham et al 1997;Blagitko et al 1997;Hollenbach et al 2001;Gorodezky et al 2001;Layrisse et al 2001;Loeza et al 2002Arnaiz-Villena et al 2000Zhang et al 1993). Polymorphisms of the HLA system are relevant in epidemiological terms since certain alleles in populations might have occurred as an adaptive response to the presence of infectious agents or as the efffect of genetic drift.…”

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confidence: 99%

HLA Class II Alleles in the Otomi Population of the Mezquital Valley: A Genetic Approach to the History of Interethnic Migrations in the Mexican Central Plateau

Juárez-Martín¹,

González-Sobrino²,

Olvera³

et al. 2014

Human Biology

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From a historical and genetic point of view, the Otomi of the Mezquital Valley are a frontier people that have played an important role in the population dynamics of the Mexican Central Plateau. Due to the antiquity of their presence in the area, the Otomi may be bearers of ancient genetic variability, shared mainly today with other groups belonging to the Otomanguean linguistic family and with the Nahua. In this study we analyzed the HLA class II allele frequencies reported in Mexican indigenous populations, in order to provide an intraregional-level historical perspective of the genetic relationships between the Otomi of the Mezquital Valley and indigenous populations from other regions of Mexico. We examined genetic variation in HLA-DRB1 and -DQB1 loci in 66 nonrelated individuals belonging to seven indigenous communities from the Ixmiquilpan municipality in the Mezquital Valley, in the State of Hidalgo, Mexico. The variability of the HLA-DRB1 gene among the Otomi of the Mezquital Valley was mainly concentrated in five alleles: -DRB1*08:02 (31.06%), -DRB1*04:07 (25.77%), -DRB1*14:06 (7.55%), -DRB1*14:02 (6.06%), and -DRB1*16:02 (4.55%); these alleles have been previously described in other indigenous populations. The most frequent alleles at the HLA-DQB1 locus were -DQB1*03:02 (34.09%), -DQB1*04:02 (31.03%), and -DQB1*03:01 (19.7%). Furthermore, the HLA-DQB1*02:02 allele was found in the Otomi group with a frequency of 2.27%; this allele has not been reported in Mexican indigenous populations. In conclusion, the genetic constitution of the Otomi population is intermediate to the northern groups and the genetic variability shared by the peoples of the central regions of Mexico. Furthermore, HLA-DRB1 and -DQB1 allelic variability among the Otomi provides insight into the historical processes implied in the biological admixture with European, Asian, and African populations as well as in the admixture with the population of Mexico City associated with long-standing migratory processes.

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Distribution of class I and class III MHC antigens in the Tarasco Amerindians

Cited by 8 publications

References 27 publications

A Geometric Morphometric Study of Regional Craniofacial Variation in Mexico

A Geometric Morphometric Study of Regional Craniofacial Variation in Mexico

HLA-Class II Genes in Mexican Amerindian Mayas: Relatedness with Guatemalan Mayans and Other Populations

HLA Class II Alleles in the Otomi Population of the Mezquital Valley: A Genetic Approach to the History of Interethnic Migrations in the Mexican Central Plateau

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